2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Parasite Antibiotic Carbonic Anhydrase
  4. Procodazole

Procodazole  (Synonyms: Propazol; 2-Benzimidazolepropionic acid)

製品番号: HY-B1056 純度: 99.73%
COA 取扱説明書 Technical Support

Procodazole is an orally active enhancer and a non-specific active immune protector against viral and bacterial infections. Procodazole also exhibits antiparasitic activity. In addition, Procodazole is a carbonic anhydrase inhibitor with antitumor activity.

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Procodazole

Procodazole 構造式

CAS 番号 : 23249-97-0

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
100 mg $25 在庫あり
250 mg $42 在庫あり
500 mg $60 在庫あり
1 g $84 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Procodazole:

Procodazole 関連抗体

Top Publications Citing Use of Products

Parasite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

Antibiotic アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

Carbonic Anhydrase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

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  • 純度とドキュメンテーション

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製品説明

Procodazole is an orally active enhancer and a non-specific active immune protector against viral and bacterial infections. Procodazole also exhibits antiparasitic activity. In addition, Procodazole is a carbonic anhydrase inhibitor with antitumor activity[1][2].

IC50 & Target

CA IX

8.35 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
LNCaP GI50
>50 μM
Compound: 8
Antiproliferative activity against human LNCAP cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human LNCAP cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay
[PMID: 28838831]
PC-3 GI50
>50 μM
Compound: 8
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay
[PMID: 28838831]
体外実験

Procodazole (8.35 μM, 90 min) exerts its antitumor activity by inhibiting carbonic anhydrase IX, with an IC50 of 8.35 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Procodazole 関連抗体
体内実験

Procodazole (50 mg per dog, p.o., once daily for 28 days) can significantly reduce the parasite burden in Beagles infected with Toxocara canis and enhance their resistance to Toxocara canis infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Three-month-old Beagle puppies infected with 3000 embryonated Toxocara canis eggs[2]
Dosage: 50 mg per dog
Administration: Oral gavage (p.o.), once daily for 28 days
Result: Reduced the number of worms significantly in the treated group compared to the untreated group, with a 63.8% reduction in worm burden.
分子量

190.20

分子式

C10H10N2O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCC1=NC2=CC=CC=C2N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (262.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2576 mL 26.2881 mL 52.5762 mL
5 mM 1.0515 mL 5.2576 mL 10.5152 mL
10 mM 0.5258 mL 2.6288 mL 5.2576 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (13.14 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (13.14 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2576 mL 26.2881 mL 52.5762 mL 131.4406 mL
5 mM 1.0515 mL 5.2576 mL 10.5152 mL 26.2881 mL
10 mM 0.5258 mL 2.6288 mL 5.2576 mL 13.1441 mL
15 mM 0.3505 mL 1.7525 mL 3.5051 mL 8.7627 mL
20 mM 0.2629 mL 1.3144 mL 2.6288 mL 6.5720 mL
25 mM 0.2103 mL 1.0515 mL 2.1030 mL 5.2576 mL
30 mM 0.1753 mL 0.8763 mL 1.7525 mL 4.3814 mL
40 mM 0.1314 mL 0.6572 mL 1.3144 mL 3.2860 mL
50 mM 0.1052 mL 0.5258 mL 1.0515 mL 2.6288 mL
60 mM 0.0876 mL 0.4381 mL 0.8763 mL 2.1907 mL
80 mM 0.0657 mL 0.3286 mL 0.6572 mL 1.6430 mL
100 mM 0.0526 mL 0.2629 mL 0.5258 mL 1.3144 mL
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Procodazole Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Procodazole23249-97-0Propazol 2-Benzimidazolepropionic acidBacterialParasiteAntibioticCarbonic AnhydraseCarbonate dehydrataseToxocara canis Anti-infectionAnti-tumorInhibitorinhibitorinhibit

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