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Cat. No.: HY-W566406

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Aminozolamide

Aminozolamide is a carbonic anhydrase inhibitor. Aminozolamide regulates intraocular pressure by inhibiting carbonic anhydrase activity. Aminozolamide exerts local ocular effects, exhibits good retention in the ciliary body of rabbit eyes, and prevents rapid elimination from the eye. Aminozolamide is applicable to the research of ocular hypertension.

For research use only. We do not sell to patients.

CAS No.: 94641-11-9
Formula: C₇H₇N₃O₂S₂
Molecular Weight:229.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Aminozolamide Chemical Structure

CAS No.: 94641-11-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

All Carbonic Anhydrase Isoforms :

In Vivo

Aminozolamide (3%; topical ocular administration; single 50 μL instillation to one eye) reduces intraocular pressure in normotensive rabbits. Its metabolites exhibit equivalent potency, so this compound can persist in the eye to support long-term inhibition of carbonic anhydrase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

normotensive rabbits^[1]
Dosage:

3%
Administration:

topical ocular; single 50 μL instillation (to one eye)
Result:

Lowered IOP in normotensive rabbits, with potency equivalent to other ethoxzolamide analog gels tested.
Was well retained within the rabbit ciliary body, along with its 6-acetamido-2-benzothiazolesulfonamide metabolite, preventing rapid ocular removal and enabling sustained carbonic anhydrase inhibition.

Chemical Information

CAS No. 94641-11-9
Molecular Weight 229.27
Formula C₇H₇N₃O₂S₂
SMILES

O=S(=O)(N)C1=NC=2C=CC(N)=CC2S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lewis RA, et al. Aminozolamide gel: a trial of a topical carbonic anhydrase inhibitor in ocular hypertension. Archives of Ophthalmology. 1986 Jun 1;104(6):842-4.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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Aminozolamide

All Carbonic Anhydrase Isoforms