Carbonic anhydrase-IN-38 

Carbonic anhydrase-IN-38 (compound 5c) is a carbonic anhydrase inhibitor with antiproliferative activity, with K_i values of 576.2 nM, 41.3 nM and 86.9 nM against hCA VII, hCA IX and hCA XII, respectively. Carbonic anhydrase-IN-38 can be used in research related to triple-negative breast cancer and glioblastoma^[1].

Carbonic anhydrase-IN-38 (compound 5c) (15 min) inhibits recombinant human hCA I, II, VA, VII, IX, and XII with K_i values of 26300 nM, 3700 nM, 5949 nM, 576.2 nM, 41.3 nM, and 86.9 nM, respectively, and shows no measurable inhibition of hCA IV^[1].
Carbonic anhydrase-IN-38 (72 h; hypoxic conditions) potently inhibits the proliferation of hypoxic human MDA-MB-231 triple-negative breast cancer cells with an IC₅₀ of 2.4 μM and hypoxic human U87MG glioblastoma cells with an IC₅₀ of 3.6 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

272.11

C₁₈H₁₃BO₂

OB1OC2=CC=C(C3=CC=C4C=CC=CC4=C3)C=C2C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Renzi G, et al. Expanding the Inhibitory Potential of the Benzoxaborinine Scaffold against Carbonic Anhydrases: Synthesis, Structural Characterization, and In Vitro Antitumor Activity. J Med Chem. 2026;69(6):7414-7426.  [Content Brief]