Carbonic anhydrase-IN-38
Carbonic anhydrase-IN-38 (compound 5c) is a carbonic anhydrase inhibitor with antiproliferative activity, with Ki values of 576.2 nM, 41.3 nM and 86.9 nM against hCA VII, hCA IX and hCA XII, respectively. Carbonic anhydrase-IN-38 can be used in research related to triple-negative breast cancer and glioblastoma.
For research use only. We do not sell to patients.
- Formula: C18H13BO2
- Molecular Weight:272.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Carbonic anhydrase-IN-38 (compound 5c) (15 min) inhibits recombinant human hCA I, II, VA, VII, IX, and XII with Ki values of 26300 nM, 3700 nM, 5949 nM, 576.2 nM, 41.3 nM, and 86.9 nM, respectively, and shows no measurable inhibition of hCA IV[1].
Carbonic anhydrase-IN-38 (72 h; hypoxic conditions) potently inhibits the proliferation of hypoxic human MDA-MB-231 triple-negative breast cancer cells with an IC50 of 2.4 μM and hypoxic human U87MG glioblastoma cells with an IC50 of 3.6 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 272.11
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Formula C18H13BO2
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SMILES
OB1OC2=CC=C(C3=CC=C4C=CC=CC4=C3)C=C2C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carbonic anhydrase-IN-38 Related Classifications
HY-182070 Related Classifications
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