Carbonic anhydrase-IN-39
Carbonic anhydrase-IN-39 is a bacterial carbonic anhydrase inhibitor with oral bioavailability. Carbonic anhydrase-IN-39 inhibits α-NgCA and β-NgCA from Neisseria gonorrhoeae, as well as human hCA I and hCA II. Carbonic anhydrase-IN-39 exhibits bactericidal activity against Neisseria gonorrhoeae and reduces gonococcal burden in infected mouse models. Carbonic anhydrase-IN-39 can be used in the research of gonorrhea.
For research use only. We do not sell to patients.
- CAS No.: 3113099-79-6
- Formula: C11H18N4O3S2
- Molecular Weight:318.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Carbonic anhydrase-IN-39 (Compound 18) inhibits the growth of drug-resistant *Neisseria gonorrhoeae* strains CDC 178 and CDC 181 under ambient air conditions, but loses its activity in a 5% CO2 environment[1].
Carbonic anhydrase-IN-39 inhibits purified *Neisseria gonorrhoeae* α-NgCA (Ki=35.4 nM), β-NgCA (Ki=660 nM), human hCA I (Ki=60.4 nM), and human hCA II (Ki=5.3 nM) in CO2 hydration stopped-flow assays[1].
Carbonic anhydrase-IN-39 inhibits the growth of clinically isolated multidrug-resistant *Neisseria gonorrhoeae* strains under ambient air conditions[1].
Carbonic anhydrase-IN-39 (1 μM; 0-24 h) exhibits bactericidal activity against *Neisseria gonorrhoeae* WHO-X, reducing the bacterial load by approximately 4.0 Log10 CFU/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Tmax | Cmax | AUC0-24 | Vz | CL |
|---|---|---|---|---|---|---|---|
| Mice[1] | 20 mg/kg | p.o. | 0.167 h | 13.71 μM | 1.78 μM | 16.54 L/kg | 2.15 mL/min/kg |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice infected
intravaginally with N. gonorrheae WHO-X[1] -
Dosage:20 mg/kg
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Administration:p.o., two days post-infection, twice daily, three consecutive days
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Result:Had an approximately 1.5-log10 (96.84%) CFU/mL reduction in
gonococcal burden compared to vehicle-treated mice.
Chemical Information
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CAS No. 3113099-79-6
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Molecular Weight 318.42
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Formula C11H18N4O3S2
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SMILES
O=C(NC1=NN=C(S(=O)(N)=O)S1)CC2CC(C)CCC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carbonic anhydrase-IN-39 Related Classifications
HY-183668 Related Classifications
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