2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. 5,6-Dihydro-2H-pyran-2-one

5,6-Dihydro-2H-pyran-2-one (Compound 1) is a prodrug-type carbonic anhydrase inhibitor. 5,6-Dihydro-2H-pyran-2-one can specifically inhibit the tumor-associated subtype hCA IX and the cytoplasmic subtype hCA I with Ki values of 1.35 and 8.03 μM. 5,6-Dihydro-2H-pyran-2-one can be used for the research on hypoxia-related cancer.

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5,6-Dihydro-2H-pyran-2-one

5,6-Dihydro-2H-pyran-2-one Chemische Struktur

CAS. Nr. : 3393-45-1

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5,6-Dihydro-2H-pyran-2-one Related Antibodies

Top Publications Citing Use of Products

Alle Carbonic Anhydrase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

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Beschreibung

5,6-Dihydro-2H-pyran-2-one (Compound 1) is a prodrug-type carbonic anhydrase inhibitor. 5,6-Dihydro-2H-pyran-2-one can specifically inhibit the tumor-associated subtype hCA IX and the cytoplasmic subtype hCA I with Ki values of 1.35 and 8.03 μM. 5,6-Dihydro-2H-pyran-2-one can be used for the research on hypoxia-related cancer[1].

IC50 & Target[1]

hCA IX

1.35 μM (Ki)

hCA I

8.03 μM (Ki)

Molekulargewicht

98.10

Formel

C5H6O2
CAS. Nr.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C1OCCC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reinheit & Dokumentation
Verweise
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5,6-Dihydro-2H-pyran-2-one Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5,6-Dihydro-2H-pyran-2-one3393-45-1Carbonic AnhydraseCarbonate dehydrataseInhibitorinhibitorinhibit

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