Carbonic anhydrase inhibitor 27
Carbonic anhydrase inhibitor 27 (compund 5g) is an antitrypanosomal agent that reduces parasites in the bloodstream and improves survival of infected mice.
For research use only. We do not sell to patients.
- CAS No.: 167098-81-9
- Formula: C17H16N2O4
- Molecular Weight:312.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Parasite Isoforms
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Peritoneal macrophage cell | CC50 |
64 μM
Compound: 5g
|
Cytotoxicity against BALB/c mouse peritoneal macrophages after 48 hrs by MTT/LDH assay
Cytotoxicity against BALB/c mouse peritoneal macrophages after 48 hrs by MTT/LDH assay
|
[PMID: 24299463] |
| Peritoneal macrophage cell | CC50 |
92 μM
Compound: 5g
|
Cytotoxicity against BALB/c mouse peritoneal macrophages after 24 hrs by MTT/LDH assay
Cytotoxicity against BALB/c mouse peritoneal macrophages after 24 hrs by MTT/LDH assay
|
[PMID: 24299463] |
| THP-1 | IC50 |
<1 μM
Compound: 5g
|
Antitrypanosomal activity against Trypanosoma cruzi Y infected in human THP1 cells assessed as reduction of parasite burden after 48 hrs by Giemsa staining-based Neubauer chamber counting analysis
Antitrypanosomal activity against Trypanosoma cruzi Y infected in human THP1 cells assessed as reduction of parasite burden after 48 hrs by Giemsa staining-based Neubauer chamber counting analysis
|
[PMID: 24299463] |
Chemical Information
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CAS No. 167098-81-9
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Molecular Weight 312.32
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Formula C17H16N2O4
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SMILES
O=C(C1ON=C(C1)C2=CC=C(OCC3=CC=CC=C3)C=C2)NO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)