1. Metabolic Enzyme/Protease
    Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Carbonic Anhydrase
    Calcium Channel
    Sodium Channel
  3. Zonisamide

Zonisamide (Synonyms: AD 810; CI 912)

Cat. No.: HY-B0124 Purity: 99.85%
Handling Instructions

Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with Kis of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease.

For research use only. We do not sell to patients.

Zonisamide Chemical Structure

Zonisamide Chemical Structure

CAS No. : 68291-97-4

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10 mM * 1 mL in DMSO USD 113 In-stock
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200 mg USD 103 In-stock
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500 mg USD 163 In-stock
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Description

Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with Kis of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease[1][2].

IC50 & Target

Ki: 35.2 nM (hCA II) , 20.6 nM (hCA V)[2]

Clinical Trial
Molecular Weight

212.23

Formula

C₈H₈N₂O₃S

CAS No.

68291-97-4

SMILES

O=S(CC1=NOC2=C1C=CC=C2)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (471.19 mM)

H2O : 0.67 mg/mL (3.16 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7119 mL 23.5593 mL 47.1187 mL
5 mM 0.9424 mL 4.7119 mL 9.4237 mL
10 mM 0.4712 mL 2.3559 mL 4.7119 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.78 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.78 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.78 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ZonisamideAD 810 CI 912AD810AD-810CI912CI 912CI-912Carbonic AnhydraseCalcium ChannelSodium ChannelCarbonate dehydrataseCa2+ channelsCa channelsNa channelsNa+ channelscarbonicanhydraseantiepilepticsodiumchannelsneuromusculardisordersInhibitorinhibitorinhibit

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