1. Autophagy
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Autophagy
    Calcium Channel
  3. Nimodipine

Nimodipine (Synonyms: BAY-e 9736)

Cat. No.: HY-B0265 Purity: 99.87%
Handling Instructions

Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.

For research use only. We do not sell to patients.

Nimodipine Chemical Structure

Nimodipine Chemical Structure

CAS No. : 66085-59-4

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 84 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy. Target: Calcium Channel Nimodipine is main use is in the prevention of cerebral vasospasm and resultant ischemia, a complication of subarachnoid hemorrhage (a form of cerebral bleed), specifically from ruptured intracranial berry aneurysms irrespective of the patient's post-ictus neurological condition. Its administration begins within 4 days of a subarachnoid hemorrhage and is continued for three weeks. If blood pressure drops by over 5%, dosage is adjusted. There is still controversy regarding the use of intravenous nimodipine on a routine basis [1, 2].

Clinical Trial
Molecular Weight

418.44

Formula

C₂₁H₂₆N₂O₇

CAS No.

66085-59-4

SMILES

O=C(C1=C(C)NC(C)=C(C(OC(C)C)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCOC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 300 mg/mL (716.95 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3898 mL 11.9491 mL 23.8983 mL
5 mM 0.4780 mL 2.3898 mL 4.7797 mL
10 mM 0.2390 mL 1.1949 mL 2.3898 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.87%

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Keywords:

NimodipineBAY-e 9736AutophagyCalcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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Nimodipine
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HY-B0265
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