1. Membrane Transporter/Ion Channel
    Apoptosis
  2. Sodium Channel
    Apoptosis
  3. Oxcarbazepine

Oxcarbazepine (Synonyms: GP 47680)

Cat. No.: HY-B0114 Purity: 98.84%
Handling Instructions

Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects.

For research use only. We do not sell to patients.

Oxcarbazepine Chemical Structure

Oxcarbazepine Chemical Structure

CAS No. : 28721-07-5

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Solution
10 mM * 1 mL in DMSO USD 67 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 67 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 61 In-stock
Estimated Time of Arrival: December 31
50 mg USD 121 In-stock
Estimated Time of Arrival: December 31
100 mg USD 187 In-stock
Estimated Time of Arrival: December 31
500 mg USD 330 In-stock
Estimated Time of Arrival: December 31
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Description

Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

IC50 & Target

Sodium Channel[1].

In Vitro

Oxcarbazepine significantly inhibits glioblastoma cell growth and reaches IC50 at therapeutic concentrations. The IC50s of Oxcarbazepine screened with the U87 and T98 cell lines are 12.35 and 9.45 μg/mL,respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Human glioma cell lines U-87 MG and T98G
Concentration: 2.5, 5, 10, 20, and 40 μg/mL
Incubation Time: 72 hours
Result: The growth inhibition for the T98G cell line for each concentration was 17.7±4.1% (2.5 μg/mL), 21.1±3.6% (5 μg/mL), 53.6±14.2% (10 μg/mL), 82.2±2.3% (20 μg/mL), and 85.0±2.3% (40 μg/mL).
The growth inhibition for U-87 MG cell line for each concentration was −1.7±5.1% (0.008 μg/mL), 5.3±2.4% (0.08 μg/mL), 3.5±7.4% (0.8 μg/mL), 0.3±9.2% (16 μg/mL), and −4.2±9.6% (40 μg/mL).
In Vivo

Oxcarbazepine protectes mice and rats against generalized tonic-clonic seizures induced by electroshock with ED50 values between 13.5 and 20.5 mg/kg p.o. No tolerance toward this anticonvulsant effect is observed when rats are treated with Oxcarbazepine daily for 4 weeks.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

252.27

Formula

C15H12N2O2

CAS No.
SMILES

O=C(N1C2=CC=CC=C2CC(C3=CC=CC=C31)=O)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (198.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9640 mL 19.8200 mL 39.6401 mL
5 mM 0.7928 mL 3.9640 mL 7.9280 mL
10 mM 0.3964 mL 1.9820 mL 3.9640 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (10.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (10.90 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.84%

References
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Product Name:
Oxcarbazepine
Cat. No.:
HY-B0114
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