28721-07-5
28721-07-5
Chemical Structure
Oxcarbazepine
Synonym(s): GP 47680
- CAS No.: 28721-07-5
- Formula:C15H12N2O2
- Molecular Weight:252.27
IUPAC Name: 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
InChIKey: CTRLABGOLIVAIY-UHFFFAOYSA-N
SMILES: O=C(N1C2=CC=CC=C2CC(C3=CC=CC=C31)=O)N
Biological Activity: Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].
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Oxcarbazepine | 99.90% | Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects. | ||||||||||||||||||||
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Oxcarbazepine (Standard) | 99.88% | Oxcarbazepine (Standard) is the analytical standard of Oxcarbazepine. This product is intended for research and analytical applications. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects. | ||||||||||||||||||||
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Oxcarbazepine-d10 | Oxcarbazepine-d10 (GP 47680-d10) is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects. | |||||||||||||||||||||
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Oxcarbazepine-d4 | Oxcarbazepine-d4 (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects. | |||||||||||||||||||||
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Oxcarbazepine-d4-1 | Oxcarbazepine-d4-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects. | |||||||||||||||||||||
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Oxcarbazepine-d8 | Oxcarbazepine-d8-1 is a deuterium of Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Oxcarbazepine-d8-1 has anti-cancer and anticonvulsant effects. | |||||||||||||||||||||
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References
- [1]. Ashley M Thomas, et al. Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?J Pain. 2018 Jan;19(1):1-9. [Content Brief]
- [2]. Ching-Yi Lee,et al. The effects of antiepileptic drugs on the growth of glioblastoma cell lines. J Neurooncol. 2016 May;127(3):445-53. [Content Brief]
- [3]. M Schmutz, et al. Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action. Epilepsia. 1994;35 Suppl 5:S47-50. [Content Brief]
