Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD

  • Neurosci Lett. 2010 Sep 6;481(2):88-91. doi: 10.1016/j.neulet.2010.06.058.
Sumihiro Kawajiri  1 ,  Yutaka Machida ,  Shinji Saiki ,  Shigeto Sato ,  Nobutaka Hattori
Affiliations
  • 1. Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
PMID: 20600601 DOI: 10.1016/j.neulet.2010.06.058
Abstract

Zonisamide, originally known as an antiepileptic drug, has been approved in Japan as adjunctive therapy with levodopa for the treatment of Parkinson's disease (PD). Although zonisamide reduces neurotoxicity, the precise mechanism of this action is not known. Here, we show that zonisamide increases cell viability in SH-SY5Y cells via an anti-apoptotic effect and by upregulating levels of manganese superoxide dismutase (MnSOD). These results would give us novel evidences of PD treatment.

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