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DPPH free radical-scavenging activity

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37

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1

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2

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Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-112053
    DPPH
    45+ Cited Publications

    2,2-Diphenyl-1-picrylhydrazyl

    		 Reactive Oxygen Species (ROS) Metabolic Disease
    DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. DPPH method may be utilized in aqueous and nonpolar organic solvents and can be used to examine both hydrophilic and lipophilic antioxidants .
    DPPH
  • HY-P1934A
    Cyclo(L-Phe-L-Pro)

    		Fungal Bacterial IFNAR Reactive Oxygen Species (ROS) Infection Inflammation/Immunology Cancer
    Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay .
    Cyclo(L-Phe-L-Pro)
  • HY-N1417
    Sesamol
    2 Publications Verification

    		 Apoptosis Cancer
    Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC50=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities . Anticancer activities .
    Sesamol
  • HY-W019885A
    Sodium tripolyphosphate (STPP), 98%

    Sodium triphosphate pentabasic, 98%

    		 Environmental Pollutants Biochemical Assay Reagents Others
    Sodium tripolyphosphate (STPP), 98% is an inorganic, non-toxic polyphosphate crosslinker, inducer and enhancer. Sodium tripolyphosphate (STPP), 98% induces the formation of unique needle-like microcrystals in sodium alginate-chitosan composite films. Sodium tripolyphosphate (STPP), 98% enhances the DPPH free radical scavenging activity of sodium alginate-chitosan composite films .
    Sodium tripolyphosphate (STPP), 98%
  • HY-127170
    3-Hydroxycoumarin

    		Lipoxygenase Tyrosinase Metabolic Disease Inflammation/Immunology
    3-Hydroxycoumarin is an inhibitor of tyrosinase and lipoxygenase with an IC50 for recombinant human tyrosinase (rHT) of 26 μM, and a Ki of 3.39 μM; its IC50 for LOX is 9.5 μM. 3-Hydroxycoumarin has DPPH free radical scavenging activity (IC50 = 31.2 μM). 3-Hydroxycoumarin has photoprotective effects on sea urchin zygotes and embryos .
    3-Hydroxycoumarin
  • HY-112053R
    DPPH (Standard)

    2,2-Diphenyl-1-picrylhydrazyl (Standard)

    		 Reactive Oxygen Species (ROS) Reference Standards Metabolic Disease
    DPPH (Standard) is the analytical standard of DPPH. This product is intended for research and analytical applications. DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. DPPH method may be utilized in aqueous and nonpolar organic solvents and can be used to examine both hydrophilic and lipophilic antioxidants .
    DPPH (Standard)
  • HY-131803
    3'-Azido-3'-deoxyguanosine

    		Nucleoside Antimetabolite/Analog Inflammation/Immunology
    Urolignoside is an antioxidant with free radical scavenging activity. Urolignoside potently scavenges DPPH radical, and exhibits antioxidant to β-carotene-lineoleate model . 3'-Azido-3'-deoxyguanosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3'-Azido-3'-deoxyguanosine
  • HY-W002773
    Methyl isovanillate

    		Endogenous Metabolite Others
    Methyl isovanillate is a secondary metabolite isolated from Vitex agnus-castus. Methyl isovanillate does not exhibit significant activity in the DPPH free radical scavenging experiment .
    Methyl isovanillate
  • HY-N3421
    Koaburaside

    		Interleukin Related TNF Receptor Influenza Virus Infection Inflammation/Immunology Cancer
    Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC50 of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .
    Koaburaside
  • HY-130294
    Pyracrenic acid

    		Elastase Inflammation/Immunology
    Pyracrenic acid is an elastase inhibitor (IC50 = 2.42 µM), can be obtained from the bark of Pyracantha crenulata. Pyracrenic acid has DPPH free radical scavenging activity and anti-inflammatory activity .
    Pyracrenic acid
  • HY-W104752
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol

    		Bacterial Fungal Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol (Compound 3n) is an antimicrobial and antioxidant agent, that inhibits Escherichia coli and Staphylococcus epidermidis, with MIC of 8 and 4 μg/mL. 5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol exhibits antioxidant activity with IC50 of 17.47 μM using DPPH free radical-scavenging method .
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol
  • HY-175862
    ALR2-IN-9

    		Aldose Reductase Reactive Oxygen Species (ROS) PI3K Akt SOD p38 MAPK Keap1-Nrf2 Metabolic Disease
    ALR2-IN-9 is a potent ALR2 inhibitor (IC50 = 21.8 nM) with excellent antioxidant activity (EC50 for DPPH radical scavenging = 2.8 μM). ALR2-IN-9 interacts directly with Reactive Oxygen Species (ROS)/Reactive Nitrogen Species (RNS) and interrupts the free radical chain reactions, and as an endogenous enzymatic antioxidant regulator, which regulates enzyme functions of CAT and SOD. ALR2-IN-9 regulates PI3K/Akt/Nrf2 pathway to attenuate hyperglycemia-mediated mitochondrial superoxide overproduction in vitro, and ameliorates CuSO4- and H2O2-induced oxidative stress in vivo. ALR2-IN-9 prolongs lifespan of C. elegans via the regulation of stress response genes such as PMK-1. ALR2-IN-9 is a promising anti-aging drug candidate. ALR2-IN-9 can be used for diabetic complication research .
    ALR2-IN-9
  • HY-133183
    Urolignoside

    		Biochemical Assay Reagents Others
    Urolignoside is an antioxidant with free radical scavenging activity. Urolignoside potently scavenges DPPH radical, and exhibits antioxidant to β-carotene-lineoleate model .
    Urolignoside
  • HY-N8169
    10-O-Trans-p-methoxycinnamoylcatalpol

    		Others Others
    10-O-Trans-p-methoxycinnamoylcatalpol has antioxidant activity with the IC50 value of 0.37 μM/mL in DPPH free radical scavenging assay .
    10-O-Trans-p-methoxycinnamoylcatalpol
  • HY-N7518
    Eulophiol

    		MMP Inflammation/Immunology
    Eulophiol shows the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity with an EC50 of 27.7μM. Antioxidant activity .
    Eulophiol
  • HY-W714006
    Cochliodinol

    		Reactive Oxygen Species (ROS) Metabolic Disease
    Cochliodinol (compound 1) is a metabolite derived from the Apis mellifera ligustica. Cochliodinol has strong free radical scavenging activity of 2, 2-diphenyl-1-picrohydrazine (DPPH) (IC50=3.06 μg/mL) .
    Cochliodinol
  • HY-N10294
    Epicoccone B

    		HIV Infection Inflammation/Immunology
    Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC50 value of 10.8 μM, and has potent α-glucosidase inhibition with IC50 value of 27.3 μM. Anti-HIV activity .
    Epicoccone B
  • HY-N1417R
    Sesamol (Standard)

    		Reference Standards Apoptosis Cancer
    Sesamol (Standard) is the analytical standard of Sesamol. This product is intended for research and analytical applications. Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC50=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities . Anticancer activities .
    Sesamol (Standard)
  • HY-N8012
    Multinoside A

    		COX NO Synthase Others
    Multinoside A (compound 6) is an antioxidant with DPPH free radical scavenging activity (IC50=54.3 μg/mL). Multinoside A can also downregulate COX-2 expression (IC50=9.6 μg/mL) and inhibit NO production (IC50=43.9 μg/mL) .
    Multinoside A
  • HY-N15578
    Actinidioionoside

    		Others Others
    Actinidioionoside (Compound 2) is a megastigmane glucoside compound found in Borago officinalis L. Actinidioionoside has DPPH free radical scavenging activity (IC50: 41.3 μM). Actinidioionoside has no significant cytotoxicity against A549 human lung cancer cells (IC50 > 100 μM). Actinidioionoside can be used in antioxidant studies .
    Actinidioionoside
  • HY-P1934AR
    Cyclo(L-Phe-L-Pro) (Standard)

    		Reference Standards Fungal Bacterial IFNAR Reactive Oxygen Species (ROS) Infection Inflammation/Immunology Cancer
    Gallic acid (hydrate) (Standard) is the analytical standard of Gallic acid (hydrate). This product is intended for research and analytical applications. Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay .
    Cyclo(L-Phe-L-Pro) (Standard)
  • HY-N13142
    Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside

    		Others Inflammation/Immunology
    Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside (compound 3) is a flavonoid with antioxidant activity, which can be isolated from Margaritopsis carrascoana. Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside has good DPPH free radical scavenging activity (IC50=0.188 mg/mL) .
    Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside
  • HY-149517
    EGFR/BRAFV600E-IN-2

    		EGFR Raf Caspase Bcl-2 Family Apoptosis Inflammation/Immunology Cancer
    EGFR/BRAFV600E-IN-2 (compound 3g) is a potential multi-target inhibitor of EGFR, BRAF V600E, and EGFR T790M, and an inducer of apoptosis. EGFR/BRAFV600E-IN-2 can activate caspase-3, 8, and Bax, and downregulate the anti-apoptotic protein Bcl2, inducing apoptosis. EGFR/BRAF V600E-IN-2 also has antioxidant activity and DPPH free radical scavenging potency .
    EGFR/BRAFV600E-IN-2
  • HY-175851
    A2AAR antagonist 5

    		Adenosine Receptor Neurological Disease
    A2AAR antagonist 5 is a selective A2AAR antagonist. A2AAR antagonist 5 inhibits NECA-stimulated adenylyl cyclase activity in hA2AAR-expressing CHO cells with an IC50 value of 1863 nM. A2AAR antagonist 5 possesses strong free radical scavenging activity, with an EC50 value of 22.21 μM in the DPPH assay. A2AAR antagonist 5 exerts notable neuroprotective effects in in vitro cerebral ischemia models. A2AAR antagonist 5 can be used for the study of cerebral ischemia .
    A2AAR antagonist 5
  • HY-170561
    AChE/BuChE-IN-6

    		Cholinesterase (ChE) Neurological Disease
    AChE/BuChE-IN-6 (Compound 11f) is an inhibitor of AChE and BuChE, with IC50 values of 1.24 and 1.85 μg/mL, respectively. AChE/BuChE-IN-6 also exhibits strong DPPH free radical scavenging activity (IC50 = 3.15 μg/mL). In vivo toxicity studies indicate that AChE/BuChE-IN-6 is safe, showing no significant differences in blood and biochemical markers compared to the control group after long-term administration, and no abnormalities were observed in liver and kidney tissues. AChE/BuChE-IN-6 holds promise for research into Alzheimer's disease .
    AChE/BuChE-IN-6
  • HY-N15727
    2,5-Dimethylchromone-7-O-β-D-glucopyranoside

    		Others Inflammation/Immunology
    2,5-Dimethylchromone-7-O-β-D-glucopyranoside is an orally active chromone glycoside found in the underground parts of Rheum australe. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside shows a DPPH radical scavenging activity with an IC50 value of 66.9 μM. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside scavenges free radicals by providing hydrogen atoms through phenolic hydroxyl groups, inhibiting lipid peroxidation. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside is promising for research of oxidative stress-related diseases such as inflammation and skin diseases .
    2,5-Dimethylchromone-7-O-β-D-glucopyranoside
  • HY-W450115
    USF 2550A

    		Reactive Oxygen Species (ROS) Inflammation/Immunology
    USF 2550A is a class of fungus-derived 2-pyran compound with DPPH free radical scavenging activity. USF 2550A binds to DPPH free radicals in organic solvents to form adducts, thereby achieving free radical scavenging; in acetate buffer, the formed adducts undergo degradation, and the degradation products can continuously scavenge free radicals. USF 2550A can be used in antioxidant-related research .
    USF 2550A
  • HY-N9799
    Pholidotol C

    		NO Synthase Reactive Oxygen Species (ROS) Inflammation/Immunology
    Pholidotol C is a stilbene compound with nitric oxide (NO) production inhibitory activity and DPPH free radical scavenging activity (IC50 values ??of 28.6 μM and 21.9 μM, respectively). Pholidotol C exerts its anti-inflammatory and antioxidant activities through mechanisms involving the inhibition of NO production in activated macrophages and free radical scavenging, and can be used in research on inflammation-related diseases. Pholidotol C can be extracted from the dried whole plant of Pholidota chinensis (an orchid of the genus Pholidota) .
    Pholidotol C
  • HY-N17551
    Odoratumone A

    		Drug Derivative Others
    Odoratumone A (Compound 1/11) is a homoisoflavonoid identified in the rhizomes of Polygonatum odoratum (Mill.) Druce. Odoratumone A exhibits DPPH free radical scavenging activity (IC50 = 32.8 μg/mL) and exerts antioxidant properties. Odoratumone A is applicable for antioxidant research .
    Odoratumone A
  • HY-N17774
    2,3,4,6-Tetragalloylglucose

    		Reactive Oxygen Species (ROS) Others
    2,3,4,6-Tetragalloylglucose is a hydrolyzable tannin with antioxidant activity, exhibiting DPPH free radical scavenging activity (IC50=11.35 μM). 2,3,4,6-Tetragalloylglucose can be isolated from the endocarp of Juglans regia (walnut).
    2,3,4,6-Tetragalloylglucose
  • HY-N13285
    (-)-Epigallocatechin-4'-O-methylether

    (-)-EGC-4'-O-ME

    		 Drug Derivative Metabolic Disease Inflammation/Immunology
    (-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury .
    (-)-Epigallocatechin-4'-O-methylether
  • HY-N19669
    27-Hydroxyisomangiferolic acid

    		Reactive Oxygen Species (ROS) Others Metabolic Disease Inflammation/Immunology Cancer
    27-Hydroxyisomangiferolic acid, a cycloartane-type triterpene found in Indonesian propolis from East Java, acts as a weak scavenger with low free radical scavenging activity against DPPH (HY-112053) radicals. can be used for research on inflammation, heart disease, diabetes and cancer .
    27-Hydroxyisomangiferolic acid
  • HY-W002773R
    Methyl isovanillate (Standard)

    		Endogenous Metabolite Reference Standards Others
    Methyl isovanillate (Standard) is the analytical standard of Methyl isovanillate (HY-W002773). This product is intended for research and analytical applications. Methyl isovanillate is a secondary metabolite isolated from Vitex agnus-castus. Methyl isovanillate does not exhibit significant activity in the DPPH free radical scavenging experiment .
    Methyl isovanillate (Standard)
  • HY-N11962A
    2,3,9,10-Tetrahydroxyberberine bromide

    		Cholinesterase (ChE) Neurological Disease
    2,3,9,10-Tetrahydroxyberberine bromide is an acetylcholinesterase AChE inhibitor (IC50=7.8 μM). 2,3,9,10-Tetrahydroxyberberine bromide exhibits DPPH free radical scavenging activity (IC50=43 μM) and is applicable to research related to Alzheimer's disease .
    2,3,9,10-Tetrahydroxyberberine bromide
  • HY-N17763
    Styraxlignolide G

    		Others Inflammation/Immunology
    Styraxlignolide G is a furanofuran-type lignan compound that can be isolated from the stem bark of Styrax japonica. Styraxlignolide G exhibits very weak DPPH free radical scavenging activity, while its hydrolyzed aglycone molecule possesses antioxidant activity (IC50=186.7 μM) and is involved in antioxidant-related regulation in the body. Styraxlignolide G can be used in the study of inflammatory diseases.
    Styraxlignolide G
  • HY-N18001
    Plantanone A

    		COX Inflammation/Immunology
    Plantanone A is a COX inhibitor with an IC50 of 33.37 μM against ovine COX-1 and an IC50 of 46.16 μM against ovine COX-2. Plantanone A exhibits weak DPPH radical scavenging activity (IC50: 467.7 μM). Plantanone A can be used in the research of inflammation-related diseases .
    Plantanone A
  • HY-N17611
    5,6,7-Trihydroxy-4'-methoxyflavone

    4'-O-Methylscutellarein

    		 Xanthine Oxidase Cardiovascular Disease Neurological Disease
    5,6,7-Trihydroxy-4'-methoxyflavone (4'-O-Methylscutellarein) is a flavonoid and a weak inhibitor of xanthine oxidase. 5,6,7-Trihydroxy-4'-methoxyflavone possesses antithrombotic and antioxidant activities. 5,6,7-Trihydroxy-4'-methoxyflavone has an IC50 value of 25.29 µM for DPPH free radical scavenging. 5,6,7-Trihydroxy-4'-methoxyflavone can also inhibit H2O2-induced damage to PC12 cells. 5,6,7-Trihydroxy-4'-methoxyflavone is applicable for the research of diseases such as cerebrovascular disorders .
    5,6,7-Trihydroxy-4'-methoxyflavone

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