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Results for "

Endometriosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (2) Adhesion G Protein-coupled Receptors (AGPCRs) (1) Aldose Reductase (1) Apoptosis (6) Autophagy (1) Bacterial (4) Bcl-2 Family (1) Caspase (2) COX (1) Drug Derivative (4) Estrogen Receptor/ERR (6) Ferroptosis (1) Glutathione Peroxidase (1) Glycosidase (2) GnRH Receptor (20) Histamine Receptor (1) Histone Demethylase (3) IAP (2) Interleukin Related (1) Isotope-Labeled Compounds (10) Kisspeptin Receptor (1) Monoamine Oxidase (3) Nuclear Factor of activated T Cells (NFAT) (6) Nuclear Hormone Receptor 4A/NR4A (1) P2X Receptor (1) Phospholipase (1) Progesterone Receptor (17) Prostaglandin Receptor (2) Protease Activated Receptor (PAR) (2) Reactive Oxygen Species (ROS) (2) Reference Standards (10) SOD (1) Steroid Sulfatase (4) Transferrin Receptor (1) Trk Receptor (1) VD/VDR (1)
By Research Areas:	Cancer (40) Cardiovascular Disease (4) Endocrinology (46) Inflammation/Immunology (14) Metabolic Disease (7) Neurological Disease (7)
Click Chemistry:	Alkynes (4)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0084

Dienogest 2 Publications Verification STS 557	Progesterone Receptor	Endocrinology
Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-16474

Relugolix TAK-385	GnRH Receptor	Endocrinology Cancer
Relugolix (TAK-385)?is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC₅₀=0.33 nM) and monkey receptor (IC₅₀=0.32 nM) compared with TAK-013 (HY-100209) . Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al .

HY-B0554

Norethindrone 2 Publications Verification Norethisterone	Progesterone Receptor Bacterial	Endocrinology Cancer
Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-B1496

Tranylcypromine hemisulfate 5+ Cited Publications SKF 385 hemisulfate	Monoamine Oxidase Histone Demethylase	Neurological Disease Cancer
Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects .

HY-16701

BV6 Maximum Cited Publications 22 Publications Verification	IAP	Cancer
BV6 is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family. BV6 shows an IC₅₀ of 7.2 μM in MTS assays in HCC193 cells. BV6 can be used in the research of endometrial cancer and endometriosis .

HY-124748A

ENMD-1068 hydrochloride 2 Publications Verification	Protease Activated Receptor (PAR) Apoptosis	Inflammation/Immunology
ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis .

HY-14369

Elagolix sodium NBI-56418 sodium	GnRH Receptor Nuclear Factor of activated T Cells (NFAT)	Metabolic Disease Cancer
Elagolix sodium is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (K_D = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .

HY-104038

Pariceract LTI-291; BIA 28-6156	Glycosidase	Neurological Disease Endocrinology
Pariceract (LTI-291) is an activator of glucocerebrosidase (Gcase), with activation rates of more than 60% (1 μM) and between 10%-20% (0.1 μM). Pariceract can be used for Parkinson's disease and endometriosis research .

HY-14789

(R)-Elagolix NBI-56418	GnRH Receptor Nuclear Factor of activated T Cells (NFAT)	Endocrinology Cancer
Elagolix is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (K_D = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .

HY-N0864

Macranthoidin B Macranthoiside I	Apoptosis COX Reactive Oxygen Species (ROS) Caspase SOD	Cancer
Macranthoidin B (Macranthoiside I) is an orally active triterpene saponin. Macranthoidin B inhibits epithelial-mesenchymal transition in endometriosis via the COX‑2/PGE2 pathway, and also induces tumor cell apoptosis and inhibits their proliferation by regulating metabolism and increasing ROS levels . Macranthoidin B can be used in studies related to endometriosis, colorectal cancer and hepatocellular carcinoma .

HY-B1710

Norethindrone acetate 19-Norethindrone acetate	Progesterone Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Norethindrone acetate is a female hormone used for the research of endometriosis . Norethindrone acetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17557

Calcium N5-methyltetrahydrofolate 5+ Cited Publications NSC173328; 5-Methyl THF calcium	Drug Derivative	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Calcium N5-methyltetrahydrofolate (NSC173328; 5-Methyl THF (calcium)), Levomefolic acid (HY-14781) derivative, is a folic acid supplement. Calcium N5-methyltetrahydrofolate can be used for the research of neural tube defects, infertility, non-hodgkin's lymphoma, endometriosis .

HY-101405

Gestrinone 1 Publications Verification R 2323	Estrogen Receptor/ERR	Inflammation/Immunology
Gestrinone (R2323) is a synthetic steroid hormone used to treat endometriosis. It inhibits leiomyoma cells with an IC₅₀ of 43.67 μM. Gestrinone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-109093

Linzagolix KLH-2109; OBE-2109	GnRH Receptor	Inflammation/Immunology Cancer
Linzagolix (KLH-2109; OBE-2109) is a potent, non-peptide, and orally active GnRH antagonist. Linzagolix can be used for uterine fibroids, endometriosis, adenomyosis research .

HY-B0554S

Norethindrone-d6	Isotope-Labeled Compounds Progesterone Receptor	Endocrinology
Norethindrone-d₆ is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Norethindrone-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15606

Tanaproget 1 Publications Verification NSP-989	Progesterone Receptor	Endocrinology
Tanaproget is an orally effective, selective nonsteroidal progesterone receptor (PR) agonist targeting human PR with an IC₅₀ of 1.7 nM. Tanaproget promotes the interaction between PR receptors and coactivators (such as SRC-1), thereby inhibiting the secretion of matrix metalloproteinases (MMP-3/MMP-7) and reducing endometrial tissue invasion and angiogenesis. Tanaproget can be used for contraception and endometriosis inhibition research .

HY-P0056A

Histrelin acetate	GnRH Receptor	Cancer
Histrelin acetate, a GnRH analogue, is a GnRH Receptor agonist. Histrelin acetate increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin acetate can be used in the research of prostate cancer, endometriosis .

HY-111539

BAY-1316957	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
BAY-1316957 is a potent, selective and orally active prostaglandin E2 receptor subtype 4 (EP4-R) antagonist with an IC₅₀ of 15.3 nM for human EP4-R. BAY-1316957 has excellent agent metabolism and pharmacokinetics properties, and can be used for endometriosis research .

HY-P990246

Anti-Mouse F4/80 Antibody (CI:A3-1)	Adhesion G Protein-coupled Receptors (AGPCRs)	Inflammation/Immunology
Anti-Mouse F4/80 Antibody (CI:A3-1) is an anti-mouse F4/80 IgG2b monoclonal antibody. Anti-Mouse F4/80 Antibody (CI:A3-1) can clear macrophages. Anti-Mouse F4/80 Antibody (CI:A3-1) can be used for research on inflammation conditions such as endometriosis. Anti-Mouse F4/80 Antibody (CI:A3-1) often used for flow cytometry analysis and immunohistochemical analysis .

HY-134864

Lumigolix GnRH antagonist 2	GnRH Receptor	Endocrinology
Lumigolix (GnRH antagonist 2) (formula I) is a GnRH receptor antagonist that can be used for endometriosis research .

HY-159525

Linustedastatum Linustedastat; FOR-6219; OG-6219	17β-HSD	Endocrinology
Linustedastatum (Linustedastat; FOR-6219) is an orally active hydroxysteroid 17-beta dehydrogenase 1 (HSD17B1) inhibitor. Linustedastatum can be used for the study of endometriosis .

HY-156701

BAY-1128688	Aldose Reductase	Metabolic Disease Endocrinology
BAY-1128688 is a potent, orally active and selective AKR1C3 inhibitor with IC₅₀ < 2 nM. BAY-1128688 shows high selectivity over related AKR1C enzymes (1C1, 1C2, 1C4) and AKR1D1. BAY-1128688 exhibits no relevant activity at major nuclear hormone receptors. BAY-1128688 reduces endometriotic lesions in the marmoset monkey endometriosis model. BAY-1128688 can be used for endometriosis research .

HY-157493

PR antagonist 1	Progesterone Receptor	Endocrinology
PR antagonist 1 (compound 8) is a selective progesterone receptor (PR) antagonist, and can be used for the research of a variety of progesterone-related diseases and disorders such as endometriosis and uterine fibroids .

HY-P0056

Histrelin	GnRH Receptor	Cancer
Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis .

HY-160645

P2X4 antagonist-1	P2X Receptor	Neurological Disease Endocrinology Cancer
P2X4 antagonist-1 is a P2X4 receptor antagonist with an IC₅₀ of 15 nM. P2X4 antagonist-1 inhibits ATP (HY-B2176)-induced calcium influx. P2X4 antagonist-1 can be used for the research of pain syndromes, endometriosis, cancer .

HY-32345

Elocalcitol BXL-628; Ro-26-9228	VD/VDR Apoptosis	Inflammation/Immunology Endocrinology Cancer
Elocalcitol (BXL-628), a vitamin D analogue, is a selective, orally active vitamin D receptor (VDR) agonist. Elocalcitol shows anti-inflammatory activity. Elocalcitol inhibits growth of prostate cancer cells .

HY-B0084R

Dienogest (Standard) STS 557 (Standard)	Reference Standards Progesterone Receptor	Endocrinology
Dienogest (Standard) is the analytical standard of Dienogest. This product is intended for research and analytical applications. Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-16474R

Relugolix (Standard) TAK-385 (Standard)	Reference Standards GnRH Receptor	Endocrinology Cancer
Relugolix (Standard) is the analytical standard of Relugolix. This product is intended for research and analytical applications. Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC₅₀=0.33 nM) and monkey receptor (IC₅₀=0.32 nM) compared with TAK-013 (HY-100209) . Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al .

HY-B0084S2

Dienogest-d6 STS 557-d₆	Isotope-Labeled Compounds Progesterone Receptor Autophagy Apoptosis	Endocrinology Cancer
Dienogest-d₆ is deuterium labeled Dienogest (HY-B0084). Dienogest is an orally active progesterone receptor agonist that can be used in the study of endometriosis ^.

HY-129593

A-75998	GnRH Receptor	Endocrinology Cancer
A-75998 is an antagonist of luteinizing hormone-releasing hormone (LHRH). A-75998 can be used in the research of diseases such as hormone-sensitive cancers and endometriosis .

HY-178419

GnRH-R antagonist-3	GnRH Receptor	Cancer
GnRH-R antagonist-3 (Compound 37) is a Gonadotropin releasing hormone receptor (GnRH-R) antagonist with IC₅₀s of 94 and 275 nM for rat and human GnRH-R, respectively. GnRH-R antagonist-3 can be used for hormone dependent diseases such as endometriosis, breast and prostate cancer research .

HY-124748

ENMD-1068	Protease Activated Receptor (PAR) Apoptosis	Inflammation/Immunology
ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis .

HY-U00289

Opigolix ASP-1707	GnRH Receptor	Inflammation/Immunology Endocrinology
Opigolix (ASP-1707) is a Gonadotropin-releasing hormone (GnRH) receptor antagonist, used for the research of endometriosis and rheumatoid arthritis.

HY-B0554R

Norethindrone (Standard) 2 Publications Verification Norethisterone (Standard)	Reference Standards Progesterone Receptor Bacterial	Endocrinology Cancer
Norethindrone (Standard) is the analytical standard of Norethindrone. This product is intended for research and analytical applications. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-B0554S2

Norethindrone-d8 Norethisterone-d₈	Isotope-Labeled Compounds	Endocrinology Cancer
Norethindrone-d₈ (Norethisterone-d₈) is deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-105173

Teverelix EP 24332	GnRH Receptor Histamine Receptor	Endocrinology Cancer
Teverelix (EP 24332) is a GnRH antagonist. Teverelix binds competitively and reversibly to GnRH receptors, thereby suppressing the release of LH and FSH. Teverelix can be used in the research of prostatic hyperplasia, endometriosis, and prostate cancer .

HY-W746582

Norethindrone-d7 Norethisterone-d₇	Isotope-Labeled Compounds Bacterial Progesterone Receptor	Endocrinology
Norethindrone-d₇ (Norethisterone-d₇) is the deuterium labeled Norethindrone (HY-B0554). Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-16701A

BV6 TFA Maximum Cited Publications 22 Publications Verification	IAP	Cancer
BV6 TFA is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family. BV6 TFA shows an IC₅₀ of 7.2 μM in MTS assays in HCC193 cells. BV6 TFA can be used in the research of endometrial cancer and endometriosis .

HY-B1710R

Norethindrone acetate (Standard) 19-Norethindrone acetate (Standard)	Reference Standards Progesterone Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Norethindrone acetate (Standard) is the analytical standard of Norethindrone acetate. This product is intended for research and analytical applications. Norethindrone acetate is a female hormone used for the research of endometriosis . Norethindrone acetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-76737S

4-Chlorodiphenyl ether-d5 4-CDE-d₅	Isotope-Labeled Compounds Estrogen Receptor/ERR	Endocrinology
4-Chlorodiphenyl ether-d₅ (4-CDE-d₅) is the deuterium labeled 4-Chlorodiphenyl ether. 4-Chlorodiphenyl ether is an estrogen-mimicking active compound. 4-Chlorodiphenyl ether maintains the survival of endometriotic cysts and exhibits estrogenic activity associated with the growth of endometriotic implants. 4-Chlorodiphenyl ether can be used in research related to endometriosis.

HY-120767

Linzagolix choline KLH-2109 choline; OBE-2109 choline	GnRH Receptor	Inflammation/Immunology Cancer
Linzagolix choline (KLH-2109 choline) is a non-peptide gonadotropin-releasing hormone (GnRH) antagonist with oral activity. Linzagolix choline inhibits the release of endogenous gonadotropins such as luteinizing hormone LH and follicle-stimulating hormone FSH by binding to the GnRH receptor within the pituitary gland. This inhibition results in a reduction in the production of sex hormones such as estrogen and progesterone, which in turn affects the course of sex hormone-dependent diseases. Linzagolix choline can be used in the study of sex hormone-dependent diseases such as endometriosis and uterine fibroids .

HY-16474S

Relugolix-d6 TAK-385-d₆	Isotope-Labeled Compounds GnRH Receptor	Endocrinology Cancer
Relugolix-d₆ is deuterium labeled Relugolix. Relugolix (TAK-385)?is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC₅₀=0.33 nM) and monkey receptor (IC₅₀=0.32 nM) compared with TAK-013 (HY-100209) . Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al .

HY-W703425

17α-Ethynyl-19-nor-Δ-5(6)-androsten-17β-ol-3-one delta-5(6)-Norethindrone	Progesterone Receptor	Endocrinology
17α-Ethynyl-19-nor-Δ-5(6)-androsten-17β-ol-3-one (delta-5(6)-Norethindrone), an impurity of Norethindrone, is an anabolic agent. Norethindrone is a progestin athat can be used for endometriosis research .

HY-151200

Steroid sulfatase-IN-4	Steroid Sulfatase	Endocrinology
Steroid sulfatase-IN-4 (Compound 16) is an irreversible steroid sulfatase (STS) inhibitor with an IC₅₀ of 25 nM against human STS. Steroid sulfatase-IN-4 can be used for the research of endometriosis .

HY-178418

GnRH-R antagonist-2	GnRH Receptor	Cancer
GnRH-R antagonist-2 (Compound 44c) is a Gonadotropin releasing hormone receptor (GnRH-R) antagonist with IC₅₀s of 43 and 88 nM for rat and human GnRH-R, respectively. GnRH-R antagonist-2 can be used for hormone dependent diseases such as endometriosis, breast and prostate cancer research .

HY-W267205

3-Acetyl-7-Hydroxycoumarin	17β-HSD	Endocrinology Cancer
3-Acetyl-7-Hydroxycoumarin (Compound 2) is a high selective 17-beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor. 3-Acetyl-7-Hydroxycoumarin shows a significant improvement of the inhibitory potency, with 57% inhibition of 17β-HSD1 at 6 μM. 3-Acetyl-7-Hydroxycoumarin is promising for research of hormone-dependent diseases, such as breast cancer and endometriosis .

HY-151201

Steroid sulfatase/17β-HSD1-IN-3	Steroid Sulfatase	Cancer
Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with anIC₅₀ value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases .

HY-151202

Steroid sulfatase/17β-HSD1-IN-4	Steroid Sulfatase	Cancer
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC₅₀ value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases .

HY-155010

Steroid sulfatase/17β-HSD1-IN-5	Steroid Sulfatase	Metabolic Disease
Steroid sulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroid sulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), with IC₅₀s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroid sulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research .

HY-14901

Telapristone	Progesterone Receptor	Cancer
Telapristone is a Progesterone antagonist. Telapristone can be used in the study of uterine fibroids and endometriosis .

Cat. No.	Product Name	Target	Research Area

HY-P0056A

Histrelin acetate	GnRH Receptor	Cancer
Histrelin acetate, a GnRH analogue, is a GnRH Receptor agonist. Histrelin acetate increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin acetate can be used in the research of prostate cancer, endometriosis .

HY-P0056

Histrelin	GnRH Receptor	Cancer
Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis .

HY-105173

Teverelix EP 24332	GnRH Receptor Histamine Receptor	Endocrinology Cancer
Teverelix (EP 24332) is a GnRH antagonist. Teverelix binds competitively and reversibly to GnRH receptors, thereby suppressing the release of LH and FSH. Teverelix can be used in the research of prostatic hyperplasia, endometriosis, and prostate cancer .

HY-P2067

Argtide	GnRH Receptor	Endocrinology Cancer
Argtide is a luteinizing hormone-releasing hormone (LHRH) antagonist. Argtide is used in endometriosis and cancer-related research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990246

Anti-Mouse F4/80 Antibody (CI:A3-1)	Adhesion G Protein-coupled Receptors (AGPCRs)	Inflammation/Immunology
Anti-Mouse F4/80 Antibody (CI:A3-1) is an anti-mouse F4/80 IgG2b monoclonal antibody. Anti-Mouse F4/80 Antibody (CI:A3-1) can clear macrophages. Anti-Mouse F4/80 Antibody (CI:A3-1) can be used for research on inflammation conditions such as endometriosis. Anti-Mouse F4/80 Antibody (CI:A3-1) often used for flow cytometry analysis and immunohistochemical analysis .

HY-P992035

AMY109	Interleukin Related	Endocrinology
AMY109 is an anti-human interleukin-8 (IL-8) monoclonal antibody, with a K_a of 36.8 pM for human IL-8, and a K_a of 380 pM for cynomolgus monkey IL-8. AMY109 binds to human and cynomolgus monkey IL-8 in a pH-dependent manner, inhibits IL-8-mediated activation of CXCR1 and CXCR2, and blocks the downstream biological activities of IL-8. AMY109 inhibits neutrophil recruitment to endometriotic lesions and suppresses monocyte chemoattractant protein-1 production by neutrophils. AMY109 is applicable to research related to endometriosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0864

Macranthoidin B Macranthoiside I	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Apoptosis COX Reactive Oxygen Species (ROS) Caspase SOD
Macranthoidin B (Macranthoiside I) is an orally active triterpene saponin. Macranthoidin B inhibits epithelial-mesenchymal transition in endometriosis via the COX‑2/PGE2 pathway, and also induces tumor cell apoptosis and inhibits their proliferation by regulating metabolism and increasing ROS levels . Macranthoidin B can be used in studies related to endometriosis, colorectal cancer and hepatocellular carcinoma .

HY-N0864R

Macranthoidin B (Standard) Macranthoiside I (Standard)	Triterpenes Structural Classification other families Terpenoids Plants Source Classification	Reference Standards Others
Macranthoidin B (Macranthoiside I) Standard is the analytical standard of Macranthoidin B (HY-N0864). This product is intended for research and analytical applications. Macranthoidin B (Macranthoiside I) is an orally active triterpene saponin. Macranthoidin B inhibits epithelial-mesenchymal transition in endometriosis via the COX‑2/PGE2 pathway, and also induces tumor cell apoptosis and inhibits their proliferation by regulating metabolism and increasing ROS levels . Macranthoidin B can be used in studies related to endometriosis, colorectal cancer and hepatocellular carcinoma .

HY-N7748A

Epi-cryptoacetalide	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Estrogen Receptor/ERR Prostaglandin Receptor
Epi-cryptoacetalide is a natural diterpenoid. Epi-cryptoacetalide reveals high affinity to ER-α and PGE2 receptor (EP2 subtype) with K_i values of 0.3 μM and 1.92 μM, respectively. Epi-cryptoacetalide has anti-endometriosis activities .

Cat. No.	Product Name	Chemical Structure

HY-B0554S

Norethindrone-d6

Norethindrone-d₆ is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Norethindrone-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0084S2

Dienogest-d6
Dienogest-d₆ is deuterium labeled Dienogest (HY-B0084). Dienogest is an orally active progesterone receptor agonist that can be used in the study of endometriosis ^.

HY-B0554S2

Norethindrone-d8
Norethindrone-d₈ (Norethisterone-d₈) is deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-W746582

Norethindrone-d7
Norethindrone-d₇ (Norethisterone-d₇) is the deuterium labeled Norethindrone (HY-B0554). Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-76737S

4-Chlorodiphenyl ether-d5
4-Chlorodiphenyl ether-d₅ (4-CDE-d₅) is the deuterium labeled 4-Chlorodiphenyl ether. 4-Chlorodiphenyl ether is an estrogen-mimicking active compound. 4-Chlorodiphenyl ether maintains the survival of endometriotic cysts and exhibits estrogenic activity associated with the growth of endometriotic implants. 4-Chlorodiphenyl ether can be used in research related to endometriosis.

HY-16474S

Relugolix-d6

Relugolix-d₆ is deuterium labeled Relugolix. Relugolix (TAK-385)?is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC₅₀=0.33 nM) and monkey receptor (IC₅₀=0.32 nM) compared with TAK-013 (HY-100209) . Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al .

HY-B0554S1

Norethindrone-13C2
Norethindrone- ¹³C₂ (Norethisterone- ¹³C₂) is the ¹³C labeled Norethindrone (HY-B0554) . Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea .

HY-17447SA

Tranylcypromine-d5 hydrochloride

Tranylcypromine-d₅ (hydrochloride) is a deuterium labeled (rel)-Tranylcypromine hydrochloride. Tranylcypromine hydrochloride is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hydrochloride is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis .

HY-W751574

Elagolix-d6 sodium
Elagolix-d₆ (sodium) (NBI-56418-d₆ (sodium)) is deuterium labeled Elagolix sodium. Elagolix sodium is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (K_D = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .

HY-B0084S4

Dienogest-13C,15N,d4

Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-115633S

Elagolix-d9
Elagolix-d₉ is the deuterium labeled Elagolix. Elagolix sodium is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (K_D = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .

Cat. No.	Product Name		Classification

HY-B0554

Norethindrone 2 Publications Verification Norethisterone		Alkynes
Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-B1710

Norethindrone acetate 19-Norethindrone acetate		Alkynes
Norethindrone acetate is a female hormone used for the research of endometriosis . Norethindrone acetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101405

Gestrinone 1 Publications Verification R 2323		Alkynes
Gestrinone (R2323) is a synthetic steroid hormone used to treat endometriosis. It inhibits leiomyoma cells with an IC₅₀ of 43.67 μM. Gestrinone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0554S

Norethindrone-d6		Alkynes
Norethindrone-d₆ is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Norethindrone-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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