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Cat. No.: HY-16290

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Lonaprisan

(Synonyms: ZK 230211; BAY86 5044)

Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC₅₀ of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect.

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CAS No.: 211254-73-8
화학식: C₂₈H₂₉F₅O₃
분자량:508.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Lonaprisan Chemical Structure

CAS No.: 211254-73-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC₅₀: 3.6 pM (progesterone receptor A), 2.5 pM (progesterone receptor B)

Cellular Effect

Cell Line	Type	Value	Description	References
CV-1	IC₅₀	54 nM Compound: ZK-230211	In vitro antagonist potency in transactivation assay in CV-1 cells expressing androgen receptor In vitro antagonist potency in transactivation assay in CV-1 cells expressing androgen receptor	[PMID: 11150172]
NIH3T3	IC₅₀	16 nM Compound: ZK-230211	In vitro antagonist potency in transactivation assay in NIH3T3 cells expressing glucocorticoid receptor In vitro antagonist potency in transactivation assay in NIH3T3 cells expressing glucocorticoid receptor	[PMID: 11150172]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 211254-73-8
분자량 508.52
화학식 C₂₈H₂₉F₅O₃
SMILES

O=C1CCC2=C3[C@@H](C4=CC=C(C(C)=O)C=C4)C[C@@]5(C)[C@](CC[C@@]5(O)C(F)(C(F)(F)F)F)([H])[C@]3([H])CCC2=C1
Synonyms

ZK 230211; BAY86 5044
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fuhrmann U, et al., Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist. J Med Chem. 2000 Dec 28;43(26):5010-6. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- Clinical Trial
Chemical Information
순도&문서
References

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Lonaprisan

High-Throughput Bioactive Compound Library

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Lonaprisan Related Classifications

HY-16290 Related Classifications