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Cat. No.: HY-184012

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BAY-163

BAY-163 is a tertiary urea derivative and inactive negative control probe for BAY-439 (HY-178123). BAY-163 does not inhibit phospholipase A2 group V (PLA2-G5) activity in immune cells. BAY-163 can be used for research on endometriosis.

For research use only. We do not sell to patients.

CAS No.: 3134928-97-2
Formula: C₂₃H₂₈N₄O₂
Molecular Weight:392.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BAY-163 Chemical Structure

CAS No.: 3134928-97-2

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biological Activity

Description

IC₅₀ & Target^[1]

PLA2

All Phospholipase Isoforms :

In Vitro

BAY-163 shows no inhibitory activity against human phospholipase A2 group V (hPLA2-G5) at concentrations up to 25 μM^[1].
BAY-163 does not bind to human phospholipase A2 group V (hPLA2-G5) at concentrations up to 10 μM^[1].
BAY-163 shows no inhibitory activity against rat phospholipase A₂ group V (rPLA₂-G5) at concentrations up to 20 μM^[1].
BAY-163 shows no inhibitory activity against human cytosolic phospholipase A₂ group IVA (hPLA₂-G4A) or human phospholipase A₂ group VII (hPLA₂-G7) at concentrations up to 20 μM^[1].
BAY-163 shows no inhibitory activity against human secretory phospholipase A2 group IIA (hPLA2-G2A) at concentrations up to 20 μM, and weak inhibitory activity against human secretory phospholipase A2 group X (hPLA2-G10) with an IC₅₀ of 14.3 μM^[1].
BAY-163 shows no inhibitory activity against phospholipase A2 group V (PLA2-G5) in THP-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3134928-97-2
Molecular Weight 392.49
Formula C₂₃H₂₈N₄O₂
SMILES

O=C(N(C)C)N(CC1)CCC1OC2=CC=C(C#CC3=CC=NC(NCC)=C3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Langer G, et al. Identification of the Piperidyl Urea Derivative BAY-439 as a Potent and Selective Inhibitor of Human Phospholipase A2 Group V (hPLA2-G5) for the Treatment of Inflammatory Pain. J Med Chem. 2026 May 19. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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BAY-163

All Phospholipase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BAY-163 Related Classifications

HY-184012 Related Classifications