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Cat. No.: HY-178418

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GnRH-R antagonist-2

GnRH-R antagonist-2 (Compound 44c) is a Gonadotropin releasing hormone receptor (GnRH-R) antagonist with IC₅₀s of 43 and 88 nM for rat and human GnRH-R, respectively. GnRH-R antagonist-2 can be used for hormone dependent diseases such as endometriosis, breast and prostate cancer research.

For research use only. We do not sell to patients.

CAS No.: 1000819-21-5
Formula: C₃₇H₅₀N₄O₃S
Molecular Weight:630.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

GnRH-R antagonist-2 Chemical Structure

CAS No.: 1000819-21-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	88 nM Compound: 44	Displacement of [125I]D-Trp from human GnRH receptor expressed in HEK cells Displacement of [125I]D-Trp from human GnRH receptor expressed in HEK cells	[PMID: 17937987]
Pituitary gland cell	IC₅₀	220 nM Compound: 44	Antagonist activity at GnRH receptor expressed in AP Han Wistar rat primary pituitary cells assessed as inhibition of GnRH stimulated LH release after 24 hrs Antagonist activity at GnRH receptor expressed in AP Han Wistar rat primary pituitary cells assessed as inhibition of GnRH stimulated LH release after 24 hrs	[PMID: 17937987]

Chemical Information

CAS No. 1000819-21-5
Molecular Weight 630.88
Formula C₃₇H₅₀N₄O₃S
SMILES

O=C(C1CCN(CC1C)CCC2=C(C3=CC(C)=CC(C)=C3)NC4=C2C=C(C(C)(C)C(N5C6CCC5CC6)=O)S4)N7CCOCC7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Arnould JC, et al. Synthesis and structure-activity relationships of thieno[2,3-b]pyrroles as antagonists of the GnRH receptor. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6448-54. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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