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Steroid sulfatase-IN-4 

Cat. No.: HY-151200
Handling Instructions

Steroid sulfatase-IN-4 (Compound 16) is an irreversible steroid sulfatase (STS) inhibitor with an IC50 of 25 nM against human STS. Steroid sulfatase-IN-4 can be used for the research of endometriosis.

For research use only. We do not sell to patients.

Steroid sulfatase-IN-4 Chemical Structure

Steroid sulfatase-IN-4 Chemical Structure

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Description

Steroid sulfatase-IN-4 (Compound 16) is an irreversible steroid sulfatase (STS) inhibitor with an IC50 of 25 nM against human STS. Steroid sulfatase-IN-4 can be used for the research of endometriosis[1].

IC50 & Target

IC50: 25 nM (hSTS in cellular assays)[1]

In Vitro

Steroid sulfatase-IN-4 (Compound 16) shows good metabolic stability in human hepatic S9 fraction and low intrinsic clearance Clint (<30 μL/min/mg protein)[1].
Steroid sulfatase-IN-4 (20 μM; 24 h) shows cytotoxicity for HEK-293 cells (53.6% inhibition)[1].
Steroid sulfatase-IN-4 (1 μM) shows 25% inhibition against human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) in a cell-free assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

420.87

Formula

C19H17ClN2O5S

SMILES

O=S(OC1=CC=C(C2=CC=C(C(N(C)C3=CC=CC=C3C)=O)O2)C=C1Cl)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
Steroid sulfatase-IN-4
Cat. No.:
HY-151200
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