2. GPCR/G Protein
  3. GnRH Receptor
  4. GnRH-R antagonist-3

GnRH-R antagonist-3 (Compound 37) is a Gonadotropin releasing hormone receptor (GnRH-R) antagonist with IC50s of 94 and 275 nM for rat and human GnRH-R, respectively. GnRH-R antagonist-3 can be used for hormone dependent diseases such as endometriosis, breast and prostate cancer research.

For research use only. We do not sell to patients.

GnRH-R antagonist-3

GnRH-R antagonist-3 Chemical Structure

CAS No. : 666852-12-6

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GnRH-R antagonist-3 Related Antibodies

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Description

GnRH-R antagonist-3 (Compound 37) is a Gonadotropin releasing hormone receptor (GnRH-R) antagonist with IC50s of 94 and 275 nM for rat and human GnRH-R, respectively. GnRH-R antagonist-3 can be used for hormone dependent diseases such as endometriosis, breast and prostate cancer research[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
275 nM
Compound: 37
Displacement of [125I]D-Trp from human GnRH receptor expressed in HEK cells
Displacement of [125I]D-Trp from human GnRH receptor expressed in HEK cells
[PMID: 17937987]
Pituitary gland cell IC50
743 nM
Compound: 37
Antagonist activity at GnRH receptor expressed in AP Han Wistar rat primary pituitary cells assessed as inhibition of GnRH stimulated LH release after 24 hrs
Antagonist activity at GnRH receptor expressed in AP Han Wistar rat primary pituitary cells assessed as inhibition of GnRH stimulated LH release after 24 hrs
[PMID: 17937987]
Molecular Weight

645.90

Formula

C37H51N5O3S
CAS No.
SMILES

O=C(N1CCOCC1)NCC2CCN(CC2)CCC3=C(C4=CC(C)=CC(C)=C4)NC5=C3C=C(C(C)(C)C(N6C7CCC6CC7)=O)S5
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GnRH-R antagonist-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GnRH-R antagonist-3666852-12-6GnRH ReceptorGonadotropin releasing hormone receptorGNRHRGnRH-REndometriosisBreast cancerProstate cancerInhibitorinhibitorinhibit

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