2. GPCR/G Protein
  3. GnRH Receptor
  4. Histrelin

Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis.

For research use only. We do not sell to patients.

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Histrelin Chemical Structure

Histrelin Chemical Structure

CAS No. : 76712-82-8

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Histrelin Related Antibodies

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Description

Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis[1][2][5].

IC50 & Target

GnRH Receptor[1]
In Vitro

Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants[4].
Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Histrelin Related Antibodies
In Vivo

Histrelin (0.1 mg/kg, subcutaneous injection) rescues the circulating LH concentrations in Csfmop/Csfmop mice[2].
Histrelin (10,30, or 100 μg /day, subcutaneous injection) reduces the number of endometrial glands and atrophied the stroma in rabbits[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Csfmop/Csfmop mice [2]
Dosage: 0.001, 0.05, and 0.1 mg/kg
Administration: Subcutaneous injection
Result: Increased serum FSH concentrations by 4-fold.
Animal Model: Rabbits[3]
Dosage: 10, 30, or 100 μg /day
Administration: Subcutaneous injection for 4 weeks
Result: Caused a regression of the endometrial glands and a thinning of the stroma.
Clinical Trial
Molecular Weight

1323.50

Formula

C66H86N18O12
CAS No.
Sequence

{Pyr}-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt
Sequence Shortening

{Pyr}-HWSYHLRP-NHEt
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Histrelin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Histrelin76712-82-8GnRH ReceptorGonadotropin releasing hormone receptorGNRHRProstate cancerendometriosisLHvasopressinVPFSHH-N systermInhibitorinhibitorinhibit

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