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Helicase Inhibitors

" in MedChemExpress (MCE) Product Catalog:

63

Inhibitors & Agonists

1

Fluorescent Dye

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100455
    RK-33
    1 Publications Verification
    RK-33 is an RNA helicase inhibitor against DDX3, and inhibits its helicase activity.
    RK-33
  • HY-128712
    NCGC00029283

    		DNA/RNA Synthesis Cancer
    NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively .
    NCGC00029283
  • HY-148740
    Werner syndrome RecQ helicase-IN-3

    		DNA/RNA Synthesis Cancer
    Werner syndrome RecQ helicase-IN-3 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity .
    Werner syndrome RecQ helicase-IN-3
  • HY-148741
    Werner syndrome RecQ helicase-IN-4

    		DNA/RNA Synthesis Cancer
    Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity .
    Werner syndrome RecQ helicase-IN-4
  • HY-110185
    NSC 617145

    		DNA/RNA Synthesis Cancer
    NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .
    NSC 617145
  • HY-153692
    WRN inhibitor 1

    		DNA/RNA Synthesis Cancer
    WRN inhibitor 1 (example 7) is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor that inhibits WRN helicase domain activity. WRN inhibitor 1 has the potential to study cancer .
    WRN inhibitor 1
  • HY-162146
    NS3-IN-1

    		Filovirus DNA/RNA Synthesis Infection
    NS3-IN-1 (compound 302) is a potent helicase (NS3) inhibitor. NS3-IN-1 shows an potent inhibitor for yellow fever helicase .
    NS3-IN-1
  • HY-148700
    Werner syndrome RecQ helicase-IN-2

    		DNA/RNA Synthesis Cancer
    Werner syndrome RecQ helicase-IN-2 (example 57) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research .
    Werner syndrome RecQ helicase-IN-2
  • HY-148699
    HRO761

    Werner syndrome RecQ Helicase-IN-1

    		 DNA/RNA Synthesis Cancer
    HRO761 (Werner syndrome RecQ helicase-IN-1) (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research .
    HRO761
  • HY-137820
    Brr2-IN-3

    		DNA/RNA Synthesis Others
    Brr2-IN-3 is a potent and selective Brr2 helicase allosteric Inhibitor. Brr2-IN-3 inhibits helicase activity in dose-dependent manner with an IC50 value of 1.3 μM .
    Brr2-IN-3
  • HY-144798
    FWM-5

    		SARS-CoV Infection
    FWM-5 is a potent NSP13 helicase inhibitor. SARS-COV-2 NSP13 helicase enzyme plays crucial role in the virus life cycle. FWM-5 has the potential for the research of infection diseases .
    FWM-5
  • HY-146987
    FWM-3

    		SARS-CoV Infection
    FWM-3 is a potent SARS-CoV-2 NSP13 helicase inhibitor .
    FWM-3
  • HY-144800
    FWM-1

    		SARS-CoV Infection
    FWM-1 is a potent SARS-COV-2 NSP13 helicase enzyme inhibitor with binding free energy equals -328.6 kcal/mol. FWM-1 effectively disrupts the binding of ATP to the SARS-COV2 helicase enzyme .
    FWM-1
  • HY-158116
    VVD-214

    RO7589831; VVD-133214

    		 DNA/RNA Synthesis Cancer
    VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers.
    VVD-214
  • HY-14809
    Amenamevir

    ASP2151

    		 HSV Infection
    Amenamevir is a helicase-primase inhibitor which has potent antiviral activity against HSVs with an EC50 of 14 ng/mL.
    Amenamevir
  • HY-144799
    FWM-4

    		SARS-CoV Infection
    FWM-4 is a potent SARS-COV-2 NSP13 helicase enzyme inhibitor .
    FWM-4
  • HY-153973
    WRN inhibitor 2

    		DNA/RNA Synthesis Cancer
    WRN inhibitor 2 (example 118) is a WRN (Werner Syndrome ATP dependent helicase enzyme) inhibitor, with pIC50 ≥ 7.0 .
    WRN inhibitor 2
  • HY-160009
    DHX9-IN-5

    		DNA/RNA Synthesis Cancer
    DHX9-IN-5 (compound 277) is a RNA helicase DHX9 inhibitor with an IC50 of 4.3 nM .
    DHX9-IN-5
  • HY-149887
    H3B-968

    		DNA/RNA Synthesis Cancer
    H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC50=~10 nM)，which acts function as helicase，ATPase，and exonuclease. WRN exhibits synthetic lethal activity in cancer research. However，H3B-968 inhibits WRN helicase activity，competitively with ATP .
    H3B-968
  • HY-D0306
    Tris(4-aminophenyl)methane

    Leucopararosaniline

    		 HCV Infection
    Tris(4-aminophenyl)methane is a triphenylmethane dye. Tris(4-aminophenyl)methane is a weak HCV helicase inhibitor.
    Tris(4-aminophenyl)methane
  • HY-160007
    DHX9-IN-3

    		DNA/RNA Synthesis Cancer
    DHX9-IN-3 (Compound 621) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research .
    DHX9-IN-3
  • HY-160008
    DHX9-IN-4

    		DNA/RNA Synthesis Cancer
    DHX9-IN-4 (Compound 609) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research .
    DHX9-IN-4
  • HY-160010
    DHX9-IN-6

    		DNA/RNA Synthesis Cancer
    DHX9-IN-6 (Compound 620) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research .
    DHX9-IN-6
  • HY-150279
    PolQi2

    		DNA/RNA Synthesis Others
    PolQi2 inhibits the helicase activity of Polθ. PolQi2 improves the precision of gene editing at various loci and in different cell lines .
    PolQi2
  • HY-105387
    Heliquinomycin

    		DNA/RNA Synthesis Bacterial Topoisomerase Infection Cancer
    Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth .
    Heliquinomycin
  • HY-156579
    WRN inhibitor 3

    		DNA/RNA Synthesis Cancer
    WRN inhibitor 3 (example 110), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 3 can be used for the research of cancer .
    WRN inhibitor 3
  • HY-156580
    WRN inhibitor 4

    		DNA/RNA Synthesis Cancer
    WRN inhibitor 4 (example 107), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 4 can be used for the research of cancer .
    WRN inhibitor 4
  • HY-156581
    WRN inhibitor 5

    		DNA/RNA Synthesis Cancer
    WRN inhibitor 5 (example 157), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 5 can be used for the research of cancer .
    WRN inhibitor 5
  • HY-156782
    DHX9-IN-1

    		DNA/RNA Synthesis Cancer
    DHX9-IN-1 (example 160) is an inhibitor of ATP-dependent RNA helicase A (DHX9), with the IC50 of 9.45 nM that has antitumor activity .
    DHX9-IN-1
  • HY-156784
    DHX9-IN-2

    		DNA/RNA Synthesis Cancer
    DHX9-IN-2 (example 31) is an inhibitor of ATP-dependent RNA helicase A (DHX9), with the IC50 of 0.0698 nM that has antitumor activity .
    DHX9-IN-2
  • HY-15594
    Phen-DC3

    		DNA/RNA Synthesis Cancer
    Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.
    Phen-DC3
  • HY-157611
    DHX9-IN-17

    		DNA/RNA Synthesis Cancer
    DHX9-IN-17 (186) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.161 μM in DHX9 cellular target engagement. Used in cancer research .
    DHX9-IN-17
  • HY-157612
    DHX9-IN-16

    		DNA/RNA Synthesis Cancer
    DHX9-IN-16 (208) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.125 μM in DHX9 cellular target engagement. Used in cancer research .
    DHX9-IN-16
  • HY-157605
    DHX9-IN-11

    		DNA/RNA Synthesis Cancer
    DHX9-IN-11 (469) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.0838 μM in DHX9 cellular target engagement. Used in cancer research .
    DHX9-IN-11
  • HY-157606
    DHX9-IN-13

    		DNA/RNA Synthesis Cancer
    DHX9-IN-13 (389) is a RNA helicase DHX9 inhibitor, with an EC50 of 3.4 μM in DHX9 cellular target engagement. Used in cancer research .
    DHX9-IN-13
  • HY-157607
    DHX9-IN-15

    		DNA/RNA Synthesis Cancer
    DHX9-IN-15 (287) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.232 μM in DHX9 cellular target engagement. Used in cancer research .
    DHX9-IN-15
  • HY-157604
    DHX9-IN-9

    		DNA/RNA Synthesis Cancer
    DHX9-IN-9 (509) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.0177 μM in DHX9 cellular target engagement. Used in cancer research .
    DHX9-IN-9
  • HY-157610
    DHX9-IN-14

    		DNA/RNA Synthesis Cancer
    DHX9-IN-14 (161) is a RNA helicase DHX9 inhibitor, with an EC50 of 3.4 μM in DHX9 cellular target engagement. Used in cancer research .
    DHX9-IN-14
  • HY-157609
    DHX9-IN-12

    		DNA/RNA Synthesis Cancer
    DHX9-IN-12 (83) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.917 μM in DHX9 cellular target engagement. Used in cancer research .
    DHX9-IN-12
  • HY-157608
    DHX9-IN-10

    		DNA/RNA Synthesis Cancer
    DHX9-IN-10 (49) is a RNA helicase DHX9 inhibitor, with an EC50 of 9.04 μM in DHX9 cellular target engagement. Used in cancer research .
    DHX9-IN-10
  • HY-157603
    DHX9-IN-7

    		DNA/RNA Synthesis Cancer
    DHX9-IN-7 (550) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.105 μM in DHX9 cellular target engagement. Used in cancer research .
    DHX9-IN-7
  • HY-15594A
    Phen-DC3 Trifluoromethanesulfonate
    5 Publications Verification

    Phen-DC3 Triflate

    		 G-quadruplex Cancer
    Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.
    Phen-DC3 Trifluoromethanesulfonate
  • HY-157602
    DHX9-IN-8

    		DNA/RNA Synthesis Cancer
    DHX9-IN-8 (Compound 6) is a RNA helicase DHX9 inhibitor, with an EC50 of 3.4 μM in DHX9 cellular target engagement. Used in cancer research .
    DHX9-IN-8
  • HY-N6936
    Sennidin A

    		HCV Akt GLUT Infection
    Sennidin A, isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation .
    Sennidin A
  • HY-136638
    ML328

    		Bacterial Infection
    ML328 is a selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC50 values of 26 and 5.1 μM, respectively. ML328 is a gyrase inhibitor. ML328 strongly inhibits the growth of E. coli in the presence of phage. ML328 can be used for the research of bacterial infection .
    ML328
  • HY-129769
    CMLD012073

    		Eukaryotic Initiation Factor (eIF) Cancer
    CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 inhibits the growth of NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) .
    CMLD012073
  • HY-156418
    KY386

    		DNA/RNA Synthesis Cancer
    KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability .
    KY386
  • HY-152259
    TMV-IN-4

    		TMV Infection
    TMV-IN-4 (compound 3) is a tobacco mosaic virus (TMV) inhibitor that effectively induces resistance and enhances plant tolerance to TMV infection by interacting with TMV helicase. TMV-IN-4 enhances peroxidase and superoxide dismutase activity, thereby increasing resistance to TMV in tobacco .
    TMV-IN-4
  • HY-128729
    DNA2 inhibitor C5
    2 Publications Verification

    		 Others Cancer
    DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress .
    DNA2 inhibitor C5
  • HY-163325
    Fli-1-IN-1 fumarate

    		DNA/RNA Synthesis Cancer
    Fli-1-IN-1 (compound 21) fumarate is a FLI1 targeting agent that directly binds to and inhibits the EWS-FLI1 protein interaction. EWS-FLI1 can bind to RNA helicase A, and Fli-1-IN-1 fumarate inhibits EWS-FLI1 and has potential anticancer activity .
    Fli-1-IN-1 fumarate

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