1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)
  3. CMLD012073

CMLD012073 

Cat. No.: HY-129769
Handling Instructions

CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 against NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A).

For research use only. We do not sell to patients.

CMLD012073 Chemical Structure

CMLD012073 Chemical Structure

CAS No. : 2368900-32-5

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Description

CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 against NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A)[1].

IC50 & Target

eIF4A[1]

In Vitro

In in vitro translation assays, CMLD012073 is potent at inhibiting cap-dependent translation (FF). In ribosome recruitment experiments, CMLD012073 inhibits assembly of the 80S ribosome on the mRNA[1].

Molecular Weight

530.57

Formula

C₃₀H₃₀N₂O₇

CAS No.

2368900-32-5

SMILES

CC1=N[[email protected]@]2(O)[[email protected]](C(OC)=O)[[email protected]@H](C3=CC=CC=C3)[[email protected]]4(C5=CC=C(OC)C=C5)OC6=C(C(OC)=CC(OC)=C6)[[email protected]@]42N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CMLD012073CMLD 012073CMLD-012073Eukaryotic Initiation Factor (eIF)Inhibitorinhibitorinhibit

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