2368900-32-5
Chemical Structure
CMLD012073
- CAS No.: 2368900-32-5
- Formula:C30H30N2O7
- Molecular Weight:530.57
IUPAC Name: methyl (3aR,4R,5S,5aR,10bR)-3a-hydroxy-8,10-dimethoxy-5a-(4-methoxyphenyl)-2-methyl-5-phenyl-3a,4,5,5a-tetrahydro-1H-benzofuro[3',2':1,5]cyclopenta[1,2-d]imidazole-4-carboxylate
InChIKey: YEBNUTRZELOAAC-JFYVELCSSA-N
SMILES: CC1=N[C@@]2(O)[C@H](C(OC)=O)[C@@H](C3=CC=CC=C3)[C@]4(C5=CC=C(OC)C=C5)OC6=C(C(OC)=CC(OC)=C6)[C@@]42N1
Biological Activity: CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 inhibits the growth of NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A)[1].
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CMLD012073 | CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 inhibits the growth of NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A). | |||||||||||||||||||||
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Keywords
