Werner syndrome RecQ helicase-IN-2
Based on 1 Customer Validation
Werner syndrome RecQ helicase-IN-2 (example 57) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research.
For research use only. We do not sell to patients.
- Purity : 99.32%
- CAS No.: 2869954-51-6
- Formula: C32H34F3N9O5
- Molecular Weight:681.66
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
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Helicase |
In Vitro
Werner syndrome RecQ helicase-IN-2 (example 57) has an IC50 value of 100 nM for WRN ATPase and GI50 values of 100 nM and >10 μM for SW48 and DLD1 WRN-KO cell lines, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2869954-51-6
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Appearance Solid
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Molecular Weight 681.66
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Formula C32H34F3N9O5
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Color White to off-white
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SMILES
O=C(N1CCN(CC1)C2=C(CC)N(CC(NC3=CC=C(C(F)(F)F)C=C3C)=O)C4=NC(C5=CCOCC5)=NN4C2=O)C6=NC=NC(C)=C6O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (73.35 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.4670 mL | 7.3350 mL | 14.6701 mL | 36.6752 mL |
| 5 mM | 0.2934 mL | 1.4670 mL | 2.9340 mL | 7.3350 mL | |
| 10 mM | 0.1467 mL | 0.7335 mL | 1.4670 mL | 3.6675 mL | |
| 15 mM | 0.0978 mL | 0.4890 mL | 0.9780 mL | 2.4450 mL | |
| 20 mM | 0.0734 mL | 0.3668 mL | 0.7335 mL | 1.8338 mL | |
| 25 mM | 0.0587 mL | 0.2934 mL | 0.5868 mL | 1.4670 mL | |
| 30 mM | 0.0489 mL | 0.2445 mL | 0.4890 mL | 1.2225 mL | |
| 40 mM | 0.0367 mL | 0.1834 mL | 0.3668 mL | 0.9169 mL | |
| 50 mM | 0.0293 mL | 0.1467 mL | 0.2934 mL | 0.7335 mL | |
| 60 mM | 0.0245 mL | 0.1223 mL | 0.2445 mL | 0.6113 mL |
Werner syndrome RecQ helicase-IN-2 Related Classifications
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