DHX9-IN-6
Based on 1 Customer Validation
DHX9-IN-6 (Compound 620) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.86%
- No. CAS: 2973401-56-6
- Fòrmula: C23H18ClFN4O4S2
- Peso molecular:532.99
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas DNA/RNA Synthesis
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Actividad biológica
Descripciòn
IC50 & Target
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Helicase |
Chemical Information
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No. CAS 2973401-56-6
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Appearance Solid
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Peso molecular 532.99
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Fòrmula C23H18ClFN4O4S2
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Color White to off-white
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SMILES
O=C(C1=CC(C2=C(OCC3=CC(F)=CN=C3)C=CC=N2)=CS1)NC4=CC(Cl)=CC(NS(=O)(C)=O)=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (187.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.69 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8762 mL | 9.3810 mL | 18.7621 mL | 46.9052 mL |
| 5 mM | 0.3752 mL | 1.8762 mL | 3.7524 mL | 9.3810 mL | |
| 10 mM | 0.1876 mL | 0.9381 mL | 1.8762 mL | 4.6905 mL | |
| 15 mM | 0.1251 mL | 0.6254 mL | 1.2508 mL | 3.1270 mL | |
| 20 mM | 0.0938 mL | 0.4691 mL | 0.9381 mL | 2.3453 mL | |
| 25 mM | 0.0750 mL | 0.3752 mL | 0.7505 mL | 1.8762 mL | |
| 30 mM | 0.0625 mL | 0.3127 mL | 0.6254 mL | 1.5635 mL | |
| 40 mM | 0.0469 mL | 0.2345 mL | 0.4691 mL | 1.1726 mL | |
| 50 mM | 0.0375 mL | 0.1876 mL | 0.3752 mL | 0.9381 mL | |
| 60 mM | 0.0313 mL | 0.1564 mL | 0.3127 mL | 0.7818 mL | |
| 80 mM | 0.0235 mL | 0.1173 mL | 0.2345 mL | 0.5863 mL | |
| 100 mM | 0.0188 mL | 0.0938 mL | 0.1876 mL | 0.4691 mL |
DHX9-IN-6 Related Classifications
HY-160010 Related Classifications
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