Sennidin A
Sennidin A is an anthraquinone derivative and a HCV NS3 helicase inhibitor with an IC50 of 0.8 μM against HCV NS3 helicase. Sennidin A induces Akt phosphorylation at Ser-473 and Thr-308 and promotes GLUT4 translocation to the plasma membrane. Sennidin A inhibits HCV replication. Sennidin A stimulates glucose incorporation and 2-Deoxyglucose uptake in cells. Sennidin A does not induce tyrosine phosphorylation of the insulin receptor or insulin receptor substrate-1. Sennidin A can be used for research on type 2 diabetes and hepatitis C.
For research use only. We do not sell to patients.
- CAS No.: 641-12-3
- Formula: C30H18O10
- Molecular Weight:538.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Biological Activity
Description
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Helicase |
GLUT4 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | EC50 |
>80 μM
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Antiviral activity against Huh-7 cells harboring HCV genotype 1b subgenomic replicon assessed as reduction in luciferase activity after 72 hrs.
Antiviral activity against Huh-7 cells harboring HCV genotype 1b subgenomic replicon assessed as reduction in luciferase activity after 72 hrs.
|
26262613 |
| Huh-7 | CC50 |
>80 μM
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Cytotoxicity against human Huh-7 cells assessed by MTS assay after 72 hrs.
Cytotoxicity against human Huh-7 cells assessed by MTS assay after 72 hrs.
|
26262613 |
In Vitro
Sennidin A (0-300 μM; 30 min) stimulates glucose uptake in rat adipocytes in a dose-dependent manner, exerting insulin-mimetic and additive effects[1].
Sennidin A (300 μM; 30 min) does not induce tyrosine phosphorylation of IR or IRS-1 in rat adipocytes[1].
Sennidin A (300 μM; 30 min) stimulates the translocation of GLUT4 from low-density microsomes to the plasma membrane in rat adipocytes[1].
Sennidin A (100-300 μM; 30 min) induces Akt phosphorylation at Ser-473 and Thr-308 in rat adipocytes[1].
Sennidin A (30 min) potently inhibits HCV NS3 helicase in a cell-free FRET helicase assay with an IC50 of 0.8 µM[2].
Sennidin A (72 h) shows weak anti-HCV activity in Huh-7 cells harboring the HCV genotype 1b subgenomic replicon, with an EC50 greater than 80 µM[2].
Sennidin A (72 h) exhibits low cytotoxicity in Huh-7 cells, with a CC50 greater than 80 µM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh-7
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Concentration:Various concentrations
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Incubation Time:72 h
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Result:Exhibited a CC50 value for cytotoxicity greater than 80 µM.
Chemical Information
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CAS No. 641-12-3
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Molecular Weight 538.46
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Formula C30H18O10
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SMILES
O=C1C2=C(O)C=C(C(O)=O)C=C2[C@@]([C@@]3([H])C4=CC(C(O)=O)=CC(O)=C4C(C5=C(O)C=CC=C35)=O)([H])C6=CC=CC(O)=C16
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sennidin A Related Classifications
HY-N6936 Related Classifications
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