2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. H3B-968

H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC50=~10 nM)，which acts function as helicase，ATPase，and exonuclease. WRN exhibits synthetic lethal activity in cancer research. However，H3B-968 inhibits WRN helicase activity，competitively with ATP.

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H3B-968 Chemical Structure

H3B-968 Chemical Structure

CAS No. : 2912294-90-5

Size Price Stock Quantity
5 mg USD 290 In-stock
10 mg USD 465 In-stock
25 mg USD 930 In-stock
50 mg USD 1480 In-stock
100 mg USD 2350 In-stock
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Based on 1 publication(s) in Google Scholar

H3B-968 Related Antibodies

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Description

H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC50=~10 nM)，which acts function as helicase，ATPase，and exonuclease. WRN exhibits synthetic lethal activity in cancer research. However，H3B-968 inhibits WRN helicase activity，competitively with ATP[1].

IC50 & Target

Werner syndrome protein (WRN)[1]
Molecular Weight

548.46

Formula

C22H18F6N4O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CNS(=O)(C1=NC(C2=CC=C(OC(F)(F)F)C=C2)=CC(C(F)(F)F)=N1)=O)NC3=CC=C(CC)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (455.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8233 mL 9.1164 mL 18.2329 mL
5 mM 0.3647 mL 1.8233 mL 3.6466 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8233 mL 9.1164 mL 18.2329 mL 45.5822 mL
5 mM 0.3647 mL 1.8233 mL 3.6466 mL 9.1164 mL
10 mM 0.1823 mL 0.9116 mL 1.8233 mL 4.5582 mL
15 mM 0.1216 mL 0.6078 mL 1.2155 mL 3.0388 mL
20 mM 0.0912 mL 0.4558 mL 0.9116 mL 2.2791 mL
25 mM 0.0729 mL 0.3647 mL 0.7293 mL 1.8233 mL
30 mM 0.0608 mL 0.3039 mL 0.6078 mL 1.5194 mL
40 mM 0.0456 mL 0.2279 mL 0.4558 mL 1.1396 mL
50 mM 0.0365 mL 0.1823 mL 0.3647 mL 0.9116 mL
60 mM 0.0304 mL 0.1519 mL 0.3039 mL 0.7597 mL
80 mM 0.0228 mL 0.1140 mL 0.2279 mL 0.5698 mL
100 mM 0.0182 mL 0.0912 mL 0.1823 mL 0.4558 mL
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H3B-968 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H3B-9682912294-90-5DNA/RNA SynthesisInhibitorinhibitorinhibit

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