1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. NCGC00029283


Cat. No.: HY-128712 Purity: 99.83%
COA Handling Instructions

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively.

For research use only. We do not sell to patients.

NCGC00029283 Chemical Structure

NCGC00029283 Chemical Structure

CAS No. : 714240-31-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 528 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 528 In-stock
5 mg USD 480 In-stock
10 mg USD 800 In-stock
25 mg USD 1550 In-stock
50 mg USD 2400 In-stock
100 mg USD 3600 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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  • Purity & Documentation

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NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1].

In Vitro

NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: U2-OS cells
Concentration: 1 μM, 10 μM, 100 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Showed a reduction in U2-OS cell proliferation.
Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.94 mg/mL (20.58 mM; ultrasonic and warming and heat to 60°C)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9647 mL 14.8236 mL 29.6472 mL
5 mM 0.5929 mL 2.9647 mL 5.9294 mL
10 mM 0.2965 mL 1.4824 mL 2.9647 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.83%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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