1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. NCGC00029283

NCGC00029283 

Cat. No.: HY-128712 Purity: 99.83%
Handling Instructions

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively.

For research use only. We do not sell to patients.

NCGC00029283 Chemical Structure

NCGC00029283 Chemical Structure

CAS No. : 714240-31-0

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5 mg USD 1180 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1].

In Vitro

NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: U2-OS cells
Concentration: 1 μM, 10 μM, 100 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Showed a reduction in U2-OS cell proliferation.
Molecular Weight

337.30

Formula

C18H12FN3O3

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.94 mg/mL (20.58 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9647 mL 14.8236 mL 29.6472 mL
5 mM 0.5929 mL 2.9647 mL 5.9294 mL
10 mM 0.2965 mL 1.4824 mL 2.9647 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.83%

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Product Name:
NCGC00029283
Cat. No.:
HY-128712
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