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Results for "

Heme Oxygenase Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Heme Oxygenase (HO) (13) Adrenergic Receptor (2) Akt (3) Aldose Reductase (2) Angiotensin Receptor (2) Apoptosis (7) Bacterial (3) Biochemical Assay Reagents (4) CDK (1) Cytochrome P450 (1) Dengue Virus (1) Endogenous Metabolite (7) GSK-3 (1) IFNAR (2) Keap1-Nrf2 (8) Mitochondrial Metabolism (1) MOFs (1) NF-κB (2) p38 MAPK (2) PI3K (2) PPAR (1) Reactive Oxygen Species (ROS) (16) Reference Standards (5) Ribosomal S6 Kinase (RSK) (2) TNF Receptor (2) Tyrosinase (1) Vasopressin Receptor (1) β-catenin (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (9) Endocrinology (2) Infection (5) Inflammation/Immunology (11) Metabolic Disease (10) Neurological Disease (5)

By Targets:

Heme Oxygenase (HO) (13)

Adrenergic Receptor (2)

Akt (3)

Aldose Reductase (2)

Angiotensin Receptor (2)

Apoptosis (7)

Bacterial (3)

Biochemical Assay Reagents (4)

CDK (1)

Cytochrome P450 (1)

Dengue Virus (1)

Endogenous Metabolite (7)

GSK-3 (1)

IFNAR (2)

Keap1-Nrf2 (8)

Mitochondrial Metabolism (1)

MOFs (1)

NF-κB (2)

p38 MAPK (2)

PI3K (2)

PPAR (1)

Reactive Oxygen Species (ROS) (16)

Reference Standards (5)

Ribosomal S6 Kinase (RSK) (2)

TNF Receptor (2)

Tyrosinase (1)

Vasopressin Receptor (1)

β-catenin (1)

By Research Areas:

Cancer (17)

Cardiovascular Disease (9)

Endocrinology (2)

Infection (5)

Inflammation/Immunology (11)

Metabolic Disease (10)

Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Targets Recommended: Heme Oxygenase (HO) Serpin

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-101193

Zinc Protoporphyrin Maximum Cited Publications 67 Publications Verification Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9	Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Zinc Protoporphyrin regulates expression of HO-1 at the transcriptional level. The effect of Zinc Protoporphyrin on HO-1 expression is controversial. It was shown to induce HO-1 expression in some cells, but suppress it in others. Zinc Protoporphyrin is used as a screening marker of iron deficiency in vivo. Zinc Protoporphyrin has anti-cancer activity .

HY-N0643

Carnosol 15+ Cited Publications	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite	Cancer
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-101194

Tin protoporphyrin IX dichloride 15+ Cited Publications Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX	Reactive Oxygen Species (ROS)	Cancer
Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model .

HY-111798A

Heme Oxygenase-1-IN-1 hydrochloride 10+ Cited Publications	Reactive Oxygen Species (ROS)	Cancer
Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC₅₀ of 0.25 μM .

HY-111798

Heme Oxygenase-1-IN-1 10+ Cited Publications	Reactive Oxygen Species (ROS)	Cancer
Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC₅₀ of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research .

HY-W013812

Ethyl linoleate Linoleic Acid ethyl ester; Mandenol	Tyrosinase Akt GSK-3 β-catenin Biochemical Assay Reagents NF-κB Heme Oxygenase (HO)	Cardiovascular Disease Inflammation/Immunology
Ethyl linoleate (Linoleic Acid ethyl ester) is an orally active unsaturated fatty acid. Ethyl linoleate inhibits the Akt/GSK3β/β-catenin signaling pathway and the activation of NF-κB. Ethyl linoleate induces **heme oxygenase-1** and inhibits tyrosinase. Ethyl linoleate has whitening and anti-inflammatory effects. Ethyl linoleate promotes compound absorption. Ethyl linoleate has a significant influence on atherosclerosis. Ethyl linoleate is used in the research of inflammatory diseases. Ethyl linoleate can be used in cosmetics

HY-13707

Tin(IV) mesoporphyrin IX dichloride Stannsoporfin; SnMP	Heme Oxygenase (HO) Dengue Virus Bacterial	Infection Metabolic Disease Cancer
Tin(IV) mesoporphyrin IX dichloride (Stannsoporfin) is an orally active heme oxygenase (HO) inhibitor. Tin(IV) mesoporphyrin IX dichloride increases DENV RNA replication. Tin(IV) mesoporphyrin IX dichloride enhances the bactericidal activity of the SPaO regimen against chronic Mycobacterium tuberculosis (Mtb)-infected mice. Tin(IV) mesoporphyrin IX dichloride exhibits antitumor effects. Tin(IV) mesoporphyrin IX dichloride is being developed to prevent the development of jaundice in infants with hyperbilirubinemia .

HY-15477

YS-49 10+ Cited Publications	Akt PI3K Angiotensin Receptor Adrenergic Receptor	Cardiovascular Disease Endocrinology
YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .

HY-N0310

Soyasaponin Bb 1 Publications Verification	Aldose Reductase Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Metabolic Disease
Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities .

HY-N1353

Rhamnocitrin 2 Publications Verification	p38 MAPK	Cardiovascular Disease Inflammation/Immunology
Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC₅₀=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .

HY-B1817A

Zinc acetate, 99.99% trace metals basis Zinc(II) acetate, 99.99% trace metals basis	CDK Heme Oxygenase (HO) Apoptosis	Others
Zinc (Zinc (II)) acetate, 99.99% trace metals basis is a heme oxygenase 1 (HO-1) activator and apoptosis inducer with cytotoxic and anticancer activities. Zinc acetate, 99.99% trace metals basis enhances HO-1 expression, alters the microRNA profile, and increases the level of caspase-cleaved cytokeratin 18. Zinc acetate, 99.99% trace metals basis also regulates the expression of Cdk2/cyclin E and interferes with cell cycle progression. Zinc acetate, 99.99% trace metals basis effectively inhibits cancer cell proliferation and induces their rapid death, with no significant cytotoxicity to non-tumor tissues. Zinc acetate, 99.99% trace metals basis has been widely used in studies related to hepatocellular carcinoma, prostate cancer, and other conditions .

HY-147817

Heme Oxygenase-2-IN-1	Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Heme Oxygenase-2-IN-1 (Compound 9) is a potent, selective heme oxygenase-2 (HO-2) inhibitor with IC₅₀ values of 0.9 μM and 14.9 μM against HO-2 and HO-1, respectively .

HY-N2535

Coniferaldehyde 1 Publications Verification 4-Hydroxy-3-methoxycinnamaldehyde	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-W583212

Zn(II) Mesoporphyrin IX ZnMP	Biochemical Assay Reagents Heme Oxygenase (HO)	Inflammation/Immunology
Zn (II) Mesoporphyrin IX (ZnMP) is a **heme oxygenase** inhibitor with photochemical substrate activity. Zn (II) Mesoporphyrin IX specifically inhibits the activity of bone marrow heme oxygenase. In vitro, Zn (II) Mesoporphyrin IX inhibits the growth of erythroid and myeloid progenitor cells in rabbit bone marrow, and blocks the rhG-CSF-induced mobilization of these progenitor cells into the peripheral blood, exhibiting toxicity to hematopoietic growth and progenitor cell production in rabbits. Zn (II) Mesoporphyrin IX undergoes irreversible photochemical decomposition conforming to first-order kinetic characteristics when irradiated with UV-B in 95% ethanol solution. Zn (II) Mesoporphyrin IX can be used in hematopoietic regulation research, but its photolability and toxic effects on the hematopoietic system require attention .

HY-N5027

Oxyberberine 2 Publications Verification Oxyberberin; Berlambine; 8-Oxoberberine	Others	Infection Neurological Disease Inflammation/Immunology
Oxyberberine (Oxyberberin; Berlambine) is an orally effective heme oxygenase HO-1 agonist that can activate antioxidant mechanisms by regulating the PI3K/Akt/AMPK signaling pathway. Oxyberberine induces HO-1 expression, increases SOD and GSH-Px activity, inhibits NF-κB-mediated inflammatory responses, and improves insulin sensitivity and glucose metabolism. Oxyberberine has anti-diabetic, neuroprotective, anti-inflammatory and antioxidant effects, and can be used to study type 2 diabetes, traumatic brain injury (TBI) and inflammatory bowel disease .

HY-147517

Keap1-Nrf2-IN-9	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC₅₀ of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells .

HY-34748

3-Penten-2-one Ethylideneacetone; (3Z)-pent-3-en-2-one	Biochemical Assay Reagents Endogenous Metabolite	Inflammation/Immunology
3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) .

HY-106359A

Delmitide acetate RDP-58 acetate	TNF Receptor IFNAR Reactive Oxygen Species (ROS)	Cancer
Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide acetate can be used for the research of ulcerative colitis .

HY-15477A

YS-49 monohydrate 10+ Cited Publications	Akt PI3K Angiotensin Receptor Adrenergic Receptor	Cardiovascular Disease Endocrinology
YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .

HY-162857

Heme Oxygenase-1-IN-3	Heme Oxygenase (HO)	Neurological Disease Cancer
Heme Oxygenase-1-IN-3 (compound 4) is a highly selective heme oxygenase-1 (HO-1) inhibitor (K_d=141 nM) that can be used in the research of cancer and neurodegenerative diseases .

HY-106359

Delmitide RDP-58	TNF Receptor IFNAR Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Delmitide (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide can be used for the research of ulcerative colitis .

HY-101193R

Zinc Protoporphyrin (Standard) Zn(II)-protoporphyrin IX (Standard); ZnPP (Standard); Zinc Protoporphyrin-9 (Standard)	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
Zinc Protoporphyrin (Standard) is the analytical standard of Zinc Protoporphyrin. This product is intended for research and analytical applications. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .

HY-175660

KCL-HO-1i	Heme Oxygenase (HO)	Cancer
KCL-HO-1i is an orally active **heme oxygenase-1 (HO-1*) inhibitor* (rat HO-1: IC₅₀ = 123 nM) and human HO-1: IC₅₀ = 128 nM). KCL-HO-1i targets immunosuppressive LYVE-1 ⁺ perivascular tumor-associated macrophages (PvTAMs) in the tumor microenvironment (TME), reduces PvTAM-mediated immune exclusion. KCL-HO-1i demonstrates synergistic anti-tumor efficacy with chemotherapy in MMTV-PyMT spontaneous breast cancer mice or C57Bl/6 mice bearing subcutaneous MN-MCA1 sarcomas. KCL-HO-1i can be used for the study of cancer .

HY-115713

Heme Oxygenase-1-IN-2	Reactive Oxygen Species (ROS)	Cancer
Heme Oxygenase-1-IN-2 is a novel **heme oxygenase-1** inhibitor (IC₅₀ = 0.95 μM) with potent in vitro antiproliferative activity.

HY-W478741

Pyrraline	Endogenous Metabolite Keap1-Nrf2 NF-κB	Metabolic Disease Cancer
Pyrraline is an Nrf2 pathway activator with antioxidant and anti-inflammatory effects. Pyrraline upregulates antioxidant enzymes such as NAD(P)H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1) via antioxidant response element (ARE) activation, while inhibiting NFκB-mediated inflammation. Pyrraline is promising for research of metabolic disorders (such as diabetic nephropathy) and cancers .

HY-W583271

Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol	Vasopressin Receptor Biochemical Assay Reagents	Metabolic Disease
Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol is a heme oxygenase (HO) inhibitor, and inhibiting HO activity can reduce the release of hypothalamic hormones like AVP, OT, and ANP caused by hyperosmolarity. Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol can be used for research on hyperbilirubinemia .

HY-170867

Nrf2/HO-1 activator 3	Keap1-Nrf2 Heme Oxygenase (HO) Reactive Oxygen Species (ROS)	Cardiovascular Disease
Nrf2/HO-1 activator 3 (Compound C3a) is the activator for Nrf2 signaling pathway that promotes the Nrf2 translocation into nuclei and upregulates the expression of heme oxygenase-1 HO-1. Nrf2/HO-1 activator 3 inhibits the overespression of ROS and MDA in H₂O₂- or glucose-stimulated H9c2 cardiomyocytes, inhibits the cell viability and colony formation, thereby exhibiting antioxidant efficacy .

HY-105191

Azalanstat RS-21607	Cytochrome P450 Reactive Oxygen Species (ROS)	Metabolic Disease
Azalanstat (RS-21607) is an inhibitor of **heme oxygenase and lanosterol 14α-demethylase, with inhibitory activity against HO-1 (IC₅₀ = 5.5 µM) and HO-2 (IC₅₀** = 24.5 µM). Azalanstat reduces the maturation rate of rat oocytes, increases rat oocyte degeneration, and partially inhibits progesterone production in preovulatory follicles of rats .

HY-N0643R

Carnosol (Standard)	Reference Standards Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite	Cancer
Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-W354203

N'-Isonicotinoylisonicotinohydrazide 1,2-Diisonicotinoylhydrazine	MOFs Reactive Oxygen Species (ROS) Bacterial	Infection
N'-Isonicotinoylisonicotinohydrazide (Compound 7, 1,2-Diisonicotinoylhydrazine) is a competitive inhibitor (IC₅₀=5-30 μM) of bacterial heme oxygenase (HO). N'-Isonicotinoylisonicotinohydrazide inhibits iron release and bacterial iron acquisition. N'-Isonicotinoylisonicotinohydrazide exhibits selective activity against HO enzymes from Pseudomonas aeruginosa and Neisseria meningitidis. N'-Isonicotinoylisonicotinohydrazide is promising for research of multidrug-resistant Gram-negative bacterial infections .

HY-118487A

OB-24 free base	Endogenous Metabolite	Cancer
OB-24 free base is a compound that potently and selectively inhibits heme oxygenase 1 (HO-1) and has the potential to inhibit advanced prostate cancer. OB-24 significantly reduces protein carbonylation and the formation of reactive oxygen species by selectively inhibiting HO-1 activity in prostate cancer cells. OB-24 significantly inhibited cell proliferation in vitro and inhibited tumor growth and lymph node and lung metastasis in vivo. OB-24 exhibits powerful synergy when used in combination with Taxol .

HY-N0310R

Soyasaponin Bb (Standard)	Reference Standards Aldose Reductase Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Metabolic Disease
Soyasaponin Bb (Standard) is the analytical standard of Soyasaponin Bb (HY-N0310). This product is intended for research and analytical applications. Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities .

HY-N2535R

Coniferaldehyde (Standard) 4-Hydroxy-3-methoxycinnamaldehyde (Standard)	Reference Standards Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (Standard) is the analytical standard of Coniferaldehyde. This product is intended for research and analytical applications. Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-W424839

Probucol dithiobisphenol DTBP	Heme Oxygenase (HO)	Cardiovascular Disease
Probucol dithiobisphenol (DTBP) is the derivative of Probucol (HY-B0388). Probucol dithiobisphenol induces the production of heme oxygenase 1 (HO-1), and exhibits antioxidant activity. Probucol dithiobisphenol inhibits atherosclerotic lesions in Apoe ^−/− mice aorta, promotes re-endothelialization of aorta and inhibits restenosis in rabbit arterial injury models. Probucol dithiobisphenol is orally active .

HY-112749B

(3S,4R)-ME-344	Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Cancer
(3S,4R)-ME-344 is the (3S,4R)-enantiomer of ME-344 (HY-112749). ME-344 is a mitochondrial Heme oxygenase 1 (HO-1) inhibitor. ME-344 specifically binds and alters HO-1 structure, and increases HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells (such as H460 and SHP-77 cells). ME-344 decreases mitochondrial ATP production and induces ROS, with subsequent disruption of redox homeostasis and mitochondrial function. ME-344 has significant antitumor activity, and can be used for cancers like breast cancer research .

HY-N1353R

Rhamnocitrin (Standard)	Reference Standards Others p38 MAPK	Cardiovascular Disease Inflammation/Immunology
Rhamnocitrin (Standard) is the analytical standard of Rhamnocitrin. This product is intended for research and analytical applications. Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC₅₀=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .

HY-P11589

PIISVYWK	PPAR Reactive Oxygen Species (ROS) Keap1-Nrf2	Metabolic Disease
PIISVYWK is an orally active PPARγ Inhibitor, **heme oxygenase-1 Activator, and Nrf2** Activator. PIISVYWK mediates activity via the HO-1/Nrf2 pathway, ameliorates oxidative stress, reduces inflammation, and mediates anti-obesity activity. PIISVYWK can be used for the research of obesity .

HY-105191A

Azalanstat dihydrochloride RS-21607 dihydrochloride	Heme Oxygenase (HO)	Metabolic Disease
Azalanstat dihydrochloride (RS-21607 dihydrochloride) is an inhibitor of **heme oxygenase and lanosterol 14α-demethylase, with inhibitory activity against HO-1 (IC₅₀ = 5.5 µM) and HO-2 (IC₅₀** = 24.5 µM). Azalanstat dihydrochloride reduces the maturation rate of rat oocytes, increases rat oocyte degeneration, and partially inhibits progesterone production in preovulatory follicles of rats .

HY-183711

Antibacterial agent 344	Bacterial Heme Oxygenase (HO)	Infection
Antibacterial agent 344 is an antibacterial agent with potent biofilm inhibition (IC₅₀ = 0.27 μM). Antibacterial agent 344 inhibits **heme oxygenase (HemO*), impairs iron homeostasis, virulence factor production, and motility. Antibacterial agent 344 synergizes with Ciprofloxacin (HY-B0356) and Tobramycin (HY-B0441), enhancing their efficacy and delaying the development of resistance. Antibacterial agent 344 improves bacterial-infected Galleria mellonella* survival, and reduces bacterial load in mice wounds. Antibacterial agent 344 can be used for the research of Pseudomonas aeruginosa infections .

Cat. No.	Nombre del producto	Type

HY-B1817A

Zinc acetate, 99.99% trace metals basis Zinc(II) acetate, 99.99% trace metals basis	Biochemical Assay Reagents
Zinc (Zinc (II)) acetate, 99.99% trace metals basis is a heme oxygenase 1 (HO-1) activator and apoptosis inducer with cytotoxic and anticancer activities. Zinc acetate, 99.99% trace metals basis enhances HO-1 expression, alters the microRNA profile, and increases the level of caspase-cleaved cytokeratin 18. Zinc acetate, 99.99% trace metals basis also regulates the expression of Cdk2/cyclin E and interferes with cell cycle progression. Zinc acetate, 99.99% trace metals basis effectively inhibits cancer cell proliferation and induces their rapid death, with no significant cytotoxicity to non-tumor tissues. Zinc acetate, 99.99% trace metals basis has been widely used in studies related to hepatocellular carcinoma, prostate cancer, and other conditions .

Zinc acetate, 99.99% trace metals basis

Zinc(II) acetate, 99.99% trace metals basis

Biochemical Assay Reagents

Zinc (Zinc (II)) acetate, 99.99% trace metals basis is a heme oxygenase 1 (HO-1) activator and apoptosis inducer with cytotoxic and anticancer activities. Zinc acetate, 99.99% trace metals basis enhances HO-1 expression, alters the microRNA profile, and increases the level of caspase-cleaved cytokeratin 18. Zinc acetate, 99.99% trace metals basis also regulates the expression of Cdk2/cyclin E and interferes with cell cycle progression. Zinc acetate, 99.99% trace metals basis effectively inhibits cancer cell proliferation and induces their rapid death, with no significant cytotoxicity to non-tumor tissues. Zinc acetate, 99.99% trace metals basis has been widely used in studies related to hepatocellular carcinoma, prostate cancer, and other conditions .

HY-W583212

Zn(II) Mesoporphyrin IX ZnMP	Biochemical Assay Reagents
Zn (II) Mesoporphyrin IX (ZnMP) is a **heme oxygenase** inhibitor with photochemical substrate activity. Zn (II) Mesoporphyrin IX specifically inhibits the activity of bone marrow heme oxygenase. In vitro, Zn (II) Mesoporphyrin IX inhibits the growth of erythroid and myeloid progenitor cells in rabbit bone marrow, and blocks the rhG-CSF-induced mobilization of these progenitor cells into the peripheral blood, exhibiting toxicity to hematopoietic growth and progenitor cell production in rabbits. Zn (II) Mesoporphyrin IX undergoes irreversible photochemical decomposition conforming to first-order kinetic characteristics when irradiated with UV-B in 95% ethanol solution. Zn (II) Mesoporphyrin IX can be used in hematopoietic regulation research, but its photolability and toxic effects on the hematopoietic system require attention .

Zn(II) Mesoporphyrin IX

ZnMP

Biochemical Assay Reagents

Zn (II) Mesoporphyrin IX (ZnMP) is a heme oxygenase inhibitor with photochemical substrate activity. Zn (II) Mesoporphyrin IX specifically inhibits the activity of bone marrow heme oxygenase. In vitro, Zn (II) Mesoporphyrin IX inhibits the growth of erythroid and myeloid progenitor cells in rabbit bone marrow, and blocks the rhG-CSF-induced mobilization of these progenitor cells into the peripheral blood, exhibiting toxicity to hematopoietic growth and progenitor cell production in rabbits. Zn (II) Mesoporphyrin IX undergoes irreversible photochemical decomposition conforming to first-order kinetic characteristics when irradiated with UV-B in 95% ethanol solution. Zn (II) Mesoporphyrin IX can be used in hematopoietic regulation research, but its photolability and toxic effects on the hematopoietic system require attention .

HY-34748

3-Penten-2-one Ethylideneacetone; (3Z)-pent-3-en-2-one	Biochemical Assay Reagents
3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) .

HY-W583271

Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol	Biochemical Assay Reagents
Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol is a heme oxygenase (HO) inhibitor, and inhibiting HO activity can reduce the release of hypothalamic hormones like AVP, OT, and ANP caused by hyperosmolarity. Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol can be used for research on hyperbilirubinemia .

Cat. No.	Nombre del producto	Target	Research Area

HY-106359A

Delmitide acetate RDP-58 acetate	TNF Receptor IFNAR Reactive Oxygen Species (ROS)	Cancer
Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide acetate can be used for the research of ulcerative colitis .

HY-106359

Delmitide RDP-58	TNF Receptor IFNAR Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Delmitide (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide can be used for the research of ulcerative colitis .

HY-P11589

PIISVYWK	PPAR Reactive Oxygen Species (ROS) Keap1-Nrf2	Metabolic Disease
PIISVYWK is an orally active PPARγ Inhibitor, **heme oxygenase-1 Activator, and Nrf2** Activator. PIISVYWK mediates activity via the HO-1/Nrf2 pathway, ameliorates oxidative stress, reduces inflammation, and mediates anti-obesity activity. PIISVYWK can be used for the research of obesity .

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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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Heme Oxygenase Inhibitors

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