Search Result

Results for "

NADPH oxidase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NADPH Oxidase (43) Akt (2) AP-1 (2) Apoptosis (4) Autophagy (1) COX (1) DNA/RNA Synthesis (1) Drug Metabolite (2) ERK (3) Ferroptosis (3) Flavivirus (1) Formyl Peptide Receptor (FPR) (1) FOXO (1) Glutathione Peroxidase (1) Insulin Receptor (1) Interleukin Related (1) JAK (1) JNK (1) NF-κB (3) NO Synthase (4) p38 MAPK (4) PARP (2) Phospholipase (1) Reactive Oxygen Species (ROS) (17) Reference Standards (9) SARS-CoV (1) STAT (2) TGF-beta/Smad (1) TGF-β Receptor (2) TNF Receptor (1) TRP Channel (3) Virus Protease (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (21) Endocrinology (1) Infection (2) Inflammation/Immunology (24) Metabolic Disease (15) Neurological Disease (13)

By Targets:

NADPH Oxidase (43)

Akt (2)

AP-1 (2)

Apoptosis (4)

Autophagy (1)

COX (1)

DNA/RNA Synthesis (1)

Drug Metabolite (2)

ERK (3)

Ferroptosis (3)

Flavivirus (1)

Formyl Peptide Receptor (FPR) (1)

FOXO (1)

Glutathione Peroxidase (1)

Insulin Receptor (1)

Interleukin Related (1)

JAK (1)

JNK (1)

NF-κB (3)

NO Synthase (4)

p38 MAPK (4)

PARP (2)

Phospholipase (1)

Reactive Oxygen Species (ROS) (17)

Reference Standards (9)

SARS-CoV (1)

STAT (2)

TGF-beta/Smad (1)

TGF-β Receptor (2)

TNF Receptor (1)

TRP Channel (3)

Virus Protease (1)

By Research Areas:

Cancer (12)

Cardiovascular Disease (21)

Endocrinology (1)

Infection (2)

Inflammation/Immunology (24)

Metabolic Disease (15)

Neurological Disease (13)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: NADPH Oxidase Amino Acid Oxidase Lysyl Oxidase Glycolate Oxidase Aldehyde Oxidase (AO) Xanthine Oxidase Monoamine Oxidase Protoporphyrinogen IX oxidase VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12298

Setanaxib 25+ Cited Publications GKT137831; GKT831	NADPH Oxidase Ferroptosis	Cardiovascular Disease
Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with K_is of 140 and 110 nM, respectively.

HY-100965

Diphenyleneiodonium chloride 55+ Cited Publications DPI	TRP Channel NADPH Oxidase Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Diphenyleneiodonium chloride is a **NADPH oxidase (NOX*) inhibitor* and also functions as a TRPA1 activator with an EC₅₀ of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.

HY-18950

GSK2795039 Maximum Cited Publications 72 Publications Verification	NADPH Oxidase Reactive Oxygen Species (ROS) Apoptosis	Cancer
GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC₅₀ of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption . GSK2795039 reduces apoptosis .

HY-N0088

Apocynin 25+ Cited Publications Acetovanillone	NADPH Oxidase	Metabolic Disease Inflammation/Immunology
Apocynin is a selective *NADPH-oxidase* inhibitor with an IC₅₀ of 10 μM . Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model . Apocynin can also be used for cancer research . Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass .

HY-100111

GLX351322 45+ Cited Publications	NADPH Oxidase	Metabolic Disease
GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC₅₀ of 5 μM.

HY-12805

ML171 15+ Cited Publications 2-Acetylphenothiazine; 2-APT	NADPH Oxidase	Cardiovascular Disease
ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC₅₀ of 0.25 μM in HEK293-Nox1 confirmatory assay.

HY-12804

VAS2870 15+ Cited Publications	NADPH Oxidase	Cardiovascular Disease
VAS2870 is a NADPH oxidase (NOX) inhibitor.

HY-N1471

Liquiritin apioside 1 Publications Verification	Others	Inflammation/Immunology
Liquiritin apioside is an orally active inhibitor of TRPV1 receptor. Liquiritin apioside selectively inhibits laryngeal chemoreflex (LCR) and has no significant effect on mechanoreflex (LMR). Liquiritin apioside inhibits LCR by inhibiting reactive oxygen species (ROS) and NADPH oxidase, weakening the interaction between ROS and TRPV1. Liquiritin apioside can be used in the research of respiratory-related diseases .

HY-120801

APX-115 2 Publications Verification Ewha-18278	NADPH Oxidase	Metabolic Disease Inflammation/Immunology
APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with K_i values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury .

HY-101499

GKT136901 4 Publications Verification	NADPH Oxidase	Neurological Disease Metabolic Disease Inflammation/Immunology
GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with K_is of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity .

HY-120801A

APX-115 free base 2 Publications Verification Ewha-18278 free base; Isuzinaxib free base	NADPH Oxidase	Inflammation/Immunology Endocrinology
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with K_i values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury .

HY-W015422

1,5-Isoquinolinediol	PARP	Metabolic Disease
1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC₅₀ of 0.18-0.37 μM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina .

HY-P5381

gp91 ds-tat 1 Publications Verification	NADPH Oxidase Ferroptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase TRP Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
gp91 ds-tat, a biological active peptide, is a NADPH oxidase 2 (Nox2) inhibitor. gp91 ds-tat blocks NADPH oxidase-dependent superoxide production. gp91 ds-tat ameliorates high glucose-induced increase in total ROS, LPOs and iron levels. gp91 ds-tat inhibits homocysteine (Hcy)-induced activation of NLRP3 inflammasomes and restores Hcy-inhibited lysosomal TRPML1 channel activity. gp91 ds-tat improves cerebrovascular and cognitive function in APP/PS1 mice. gp91 ds-tat can be used for the study of Alzheimer’s disease (AD), glomerular inflammation and cardiovascular disease .

HY-P1795

Boc-dPhe-Leu-dPhe-Leu-Phe 2 Publications Verification	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Boc-dPhe-Leu-dPhe-Leu-Phe (Boc-fLfLF) is a selective N-formyl peptide receptor1 (FPR1) antagonist. Boc-dPhe-Leu-dPhe-Leu-Phe inhibits fMIFL(HY-P0224)-induced NADPH oxidase activity. Boc-dPhe-Leu-dPhe-Leu-Phe can be used for the study of inflammation .

HY-W050000

OR-1855 1 Publications Verification	Drug Metabolite Reactive Oxygen Species (ROS) ERK p38 MAPK	Cardiovascular Disease Inflammation/Immunology
OR-1855, an active metabolite of Levosimendan (HY-14286), has effect on myometrial contractility. OR-1855 exerts anti-inflammatory effects by inhibiting IL-1β-induced ROS formation and NAD(P)H oxidase-dependent superoxide radical generation in HUVECs. OR-1855 inhibits IL-1β-induced phosphorylation p38 MAPK, ERK1/2, c-Jun and JNK in HUVECs. OR-1855 can be used for the study of inflammation .

HY-107586

Demethylasterriquinone B1 DAQ B1; L-783281; Dimethylasterriquinone	Insulin Receptor Akt NO Synthase NADPH Oxidase JAK STAT FOXO DNA/RNA Synthesis ERK Flavivirus	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology
Demethylasterriquinone B1 (DAQ B1; L-783281) is an orally active insulin receptor (insulin receptor) agonist and AKT activator. By activating AKT, Demethylasterriquinone B1 upregulates the expression and activity of eNOS to increase NO production, while downregulating the expression of the *NADPH* oxidase subunit p22phox to reduce oxidative stress and improve vascular endothelial dysfunction in hypertensive rats. Demethylasterriquinone B1 combind with an AKT inhibitor targets the insulin signaling pathway to activate two antiviral pathways, RNA interference and JAK/STAT, in mosquitoes, thereby reducing Zika virus infection .

HY-152026

NADPH oxidase-IN-1	NADPH Oxidase	Neurological Disease
NADPH oxidase-IN-1 is an orally active **NADPH oxidase (Nox*) inhibitor, related with neuronal inflammation. NADPH* oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC₅₀s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy .

HY-126195

Fluoflavine ML-090	NADPH Oxidase	Neurological Disease
Fluoflavine (ML-090) is a selective NOX1 inhibitor and reactive oxygen species inhibitor. Fluoflavine reduces reactive oxygen species production, NOX1-mediated downstream signaling events, and oxygen-glucose deprivation-induced retinal ganglion cell death. Fluoflavine inhibits NADPH oxidase activity and pathological retinal neovascularization induced by oxygen-induced retinopathy in the retinas of ischemic mice. Fluoflavine can be used in studies related to retinal ischemia-reperfusion injury and proliferative retinopathy .

HY-119576

Phox-I2 1 Publications Verification	NADPH Oxidase Reactive Oxygen Species (ROS)	Inflammation/Immunology
Phox-I2 is a selective inhibitor of p67 ^phox-Rac1 interaction, binds to p67 ^phox with high affinity with a K_d of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production .

HY-P1435

NoxA1ds	NADPH Oxidase	Cardiovascular Disease Cancer
NoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds inhibits NOX1-derived O ^2- production in HT-29 human colon cancer cells. NoxA1ds attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds can be used in the study of hypertension, atherosclerosis and tumors .

HY-111447

VAS 3947	NADPH Oxidase Apoptosis	Cardiovascular Disease Cancer
VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins .

HY-101499A

GKT136901 hydrochloride 4 Publications Verification	NADPH Oxidase	Neurological Disease Metabolic Disease
GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with K_is of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity .

HY-N0088S

Apocynin-d3 Acetovanillone-d₃	Apoptosis Autophagy	Cancer
Apocynin-d₃ is the deuterium labeled Apocynin . Apocynin is a selective NADPH-oxidase inhibitor with an IC₅₀ of 10 μM .

HY-121097

Diapocynin Dehydrodiacetovanillone	NADPH Oxidase	Neurological Disease Inflammation/Immunology
Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active **NADPH oxidase** inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities .

HY-174817

NOX5-IN-1	NADPH Oxidase Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Cancer
NOX5-IN-1 (Compound 13) is a selective NADPH oxidase 5 (NOX5) inhibitor with an IC₅₀s of 0.30  μM. NOX5-IN-1 significantly inhibits NOX5-dependent production of ROS in freestyle293 cells (EC₅₀: 0.86  μM). NOX5-IN-1 can be used for NOXs related diseases research, such as cardiovascular, cancer and neuroinflammation .

HY-130579

Vinyl-L-NIO hydrochloride L-VNIO hydrochloride	NO Synthase NADPH Oxidase	Cardiovascular Disease Neurological Disease
Vinyl-L-NIO (L-VNIO) hydrochloride is a neuronal nitric oxide synthase (NOS) inhibitor with a rat K_i of 0.10 μM. Vinyl-L-NIO hydrochloride inhibits *NADPH* oxidase activity, attenuates renal fibrosis, inflammation, oxidative stress indices, and albuminuria. Vinyl-L-NIO hydrochloride can be used for the research of parkinson's disease, migraine headache, and hypertension .

HY-12805R

ML171 (Standard) 2-Acetylphenothiazine (Standard); 2-APT (Standard)	NADPH Oxidase Reference Standards	Cardiovascular Disease
ML171 (Standard) is the analytical standard of ML171. This product is intended for research and analytical applications. ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 μM in HEK293-Nox1 confirmatory assay.

HY-174818

NOX5-IN-2	NADPH Oxidase Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Cancer
NOX5-IN-2 (Compound 17) is a selective NADPH oxidase 5 (NOX5) inhibitor with an IC₅₀s of 0.70  μM. NOX5-IN-2 significantly inhibits NOX5-dependent production of ROS in freestyle293 cells (EC₅₀: 1.8  μM). NOX5-IN-2 can be used for NOXs related diseases research, such as cardiovascular, cancer and neuroinflammation .

HY-12298R

Setanaxib (Standard) GKT137831 (Standard); GKT831 (Standard)	NADPH Oxidase Ferroptosis Reference Standards	Cardiovascular Disease
Setanaxib (Standard) is the analytical standard of Setanaxib. This product is intended for research and analytical applications. Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.

HY-N2641

Dihydrotamarixetin 4'-O-Methyldihydroquercetin; Blumeatin A	NADPH Oxidase	Others
Dihydrotamarixetin (4'-O-Methyldihydroquercetin; Blumeatin A) is a flavonoid with a saturated 2,3-bond and a non-catechol B ring. Dihydrotamarixetin acts as an inhibitor of **NADPH Oxidase** .

HY-114809

AL-1	Reactive Oxygen Species (ROS) NADPH Oxidase	Inflammation/Immunology Cancer
AL-1 is a potent O2 ^- generation inhibitor (IC₅₀ = 7.6 μM) through the inhibition of leukocytic **NADPH oxidase*. AL-1 inhibits* 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced H₂O₂ production. AL-1 reduces tumor incidence in ICR mouse skin. AL-1 can be used for research on oxidative stress-related diseases including cancer .

HY-148936

GLX481372	NADPH Oxidase Reactive Oxygen Species (ROS)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
GLX481372 is a **NADPH Oxidase (NOX*) inhibitor. GLX481372 potently inhibits* NOX4/5 activities with IC₅₀ values of 0.68 and 0.57 μM. GLX481372 also has weak inhibitory activity against NOX1, NOX2, and NOX3, with IC₅₀ values of 7, 16 and 3.2 μM respectively. GLX481372 can inhibit ROS production. GLX481372 can be used for the researches of inflammation, cardiovascular and metabolic disease, such as diabetes .

HY-106981

Orazipone OR 1384	NADPH Oxidase Reactive Oxygen Species (ROS) Apoptosis NF-κB NO Synthase STAT	Inflammation/Immunology
Orazipone (OR 1384) is a small molecule immunomodulator with strong anti-inflammatory properties. Orazipone exerts its immunomodulatory effect by forming reversible thiol complexes, which bind to intracellular signaling proteins and the thiol groups of glutathione. Orazipone exhibits potent anti-eosinophilic activity by inducing apoptosis. Orazipone inhibits activation of inflammatory transcription factors NF-kB and STAT 1 and decreases inducible iNOS expression and NO production in response to inflammatory stimuli. Orazipone reduces *NADPH* oxidase activity and thereby decreases ROS production. Orazipone has a protective effect in intestinal radiation injury .

HY-136271

MJ33	Phospholipase NADPH Oxidase p38 MAPK Akt NF-κB AP-1 Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Cancer
MJ-33 is a competitive phospholipase A₂ (PLA₂) inhibitor with an IC₅₀ of 0.3 μM. MJ-33 inhibits the activation of NOX2 by blocking the PLA₂ activity of Prdx6, thereby reducing the production of ROS. MJ-33 effectively inhibits the activity of acidic PLA₂ (pH 4.0), reduces the degradation of pulmonary surfactant phosphatidylcholine (PC), but has no effect on alkaline PLA₂ (pH 8.5). MJ-33 significantly alleviates lung oxidative damage induced by ischemia-reperfusion (I/R). MJ-33 significantly inhibits the invasive, migratory and adhesive abilities of prostate cancer cells by suppressing the MAPK, AKT, NF-κB and AP-1 signaling pathways. MJ-33 can be used to study ROS-related diseases and prostate cancer .

HY-N16527

7-O-Galloyl-D-sedoheptulose	TNF Receptor Interleukin Related NADPH Oxidase Reactive Oxygen Species (ROS) NF-κB COX NO Synthase JNK AP-1 TGF-β Receptor	Metabolic Disease
7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound. 7-O-Galloyl-D-sedoheptulose lowers the serum levels of glucose, leptin, insulin, C-peptide, resistin, TNF-α, IL-6, and increases the serum level of adiponectin. 7-O-Galloyl-D-sedoheptulose significantly reduces the levels of ROS and lipid peroxidation products (TBARS) by down-regulating the protein expression of *NADPH* oxidase subunit Nox-4 and p22phox. 7-O-Galloyl-D-sedoheptulose down-regulates NF-κB and related pro-inflammatory factors (COX-2, iNOS), inhibits the phosphorylation of JNK and the activity of its downstream AP-1. 7-O-Galloyl-D-sedoheptulose reduces the expression of TGF-β1 and fibronectin, indicating its potential in anti-tissue fibrosis. 7-O-Galloyl-D-sedoheptulose can be used for the study of type 2 diabetes and its hepatic and pancreatic complications .

HY-12804R

VAS2870 (Standard)	NADPH Oxidase	Cardiovascular Disease
VAS2870 (Standard) is the analytical standard of VAS2870. This product is intended for research and analytical applications. VAS2870 is a NADPH oxidase (NOX) inhibitor.

HY-P1908

sgp91 ds-tat Peptide 2, scrambled	NADPH Oxidase	Cardiovascular Disease Cancer
sgp91 ds-tat Peptide 2, scrambled is a scrambled sequence of NADPH oxidase inhibitor gp91 ds-tat peptide .

HY-120896B

Imipramine Blue chloride	Reactive Oxygen Species (ROS)	Cancer
Imipramine Blue chloride is a potent anti-invasive agent. Imipramine Blue chloride inhibits the invasion of glioma. Imipramine Blue chloride inhibits NADPH oxidase-mediated reactive oxygen species generation .

HY-160524

NOX2-IN-3	NADPH Oxidase	Cancer
NOX2-IN-3 (compound 3) is an inhibitor of NOX2 (NADPH Oxidase 2). NOX2-IN-3 sensitizes tumor cells to MRTX1133 (HY-134813) .

HY-170540

NOX4-IN-1	NADPH Oxidase TGF-beta/Smad Reactive Oxygen Species (ROS)	Inflammation/Immunology
NOX4-IN-1 (Compound 14m) is the inhibitor for NADPH oxidase 4 (NOX4), and blocks the generation of ROS. NOX4-IN-1 inhibits TGF-β1/Smad signaling pathway, decreases the expression of fibrosis-related proteins. NOX4-IN-1 inhibits the cell migration of NRK-49F .

HY-101499AR

GKT136901 hydrochloride (Standard)	Reference Standards NADPH Oxidase	Neurological Disease Metabolic Disease
GKT136901 (hydrochloride) (Standard) is the analytical standard of GKT136901 (hydrochloride). This product is intended for research and analytical applications. GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity .

HY-N0088R

Apocynin (Standard) Acetovanillone (Standard)	Reference Standards NADPH Oxidase	Metabolic Disease Inflammation/Immunology
Apocynin (Standard) is the analytical standard of Apocynin. This product is intended for research and analytical applications. Apocynin is a selective NADPH-oxidase inhibitor with an IC₅₀ of 10 μM . Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model . Apocynin can also be used for cancer research . Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass .

HY-101499R

GKT136901 (Standard)	Reference Standards NADPH Oxidase	Neurological Disease Metabolic Disease Inflammation/Immunology
GKT136901 (Standard) is the analytical standard of GKT136901. This product is intended for research and analytical applications. GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity .

HY-P1435A

NoxA1ds TFA	NADPH Oxidase	Cardiovascular Disease Cancer
NoxA1ds TFA is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA inhibits NOX1-derived O ^2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds TFA can be used in the study of hypertension, atherosclerosis and tumors .

HY-W050000R

OR-1855 (Standard)	Drug Metabolite Reference Standards Reactive Oxygen Species (ROS) ERK p38 MAPK	Cardiovascular Disease Inflammation/Immunology
OR-1855 (Standard) is an analytical standard of OR-1855 (HY-W050000). This product is intended for research and analytical applications. OR-1855, an active metabolite of Levosimendan (HY-14286), has effect on myometrial contractility. OR-1855 exerts anti-inflammatory effects by inhibiting IL-1β-induced ROS formation and NAD(P)H oxidase-dependent superoxide radical generation in HUVECs. OR-1855 inhibits IL-1β-induced phosphorylation p38 MAPK, ERK1/2, c-Jun and JNK in HUVECs. OR-1855 can be used for the study of inflammation .

HY-W015422R

1,5-Isoquinolinediol (Standard)	Reference Standards PARP	Metabolic Disease
1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 μM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina .

HY-100965R

Diphenyleneiodonium chloride (Standard) DPI (Standard)	TRP Channel Reference Standards NADPH Oxidase Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Diphenyleneiodonium chloride (Standard) is the analytical standard of Diphenyleneiodonium chloride (HY-100965). This product is intended for research and analytical applications. Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.

HY-100111R

GLX351322 (Standard)	NADPH Oxidase Reference Standards	Metabolic Disease
GLX351322 (Standard) is the analytical standard of GLX351322 (HY-100111). This product is intended for research and analytical applications. GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM.

HY-185008

CPP11G	NADPH Oxidase	Cardiovascular Disease Inflammation/Immunology
CPP11G (Compound 11g) is a highly selective NADPH oxidase 2 (Nox2) inhibitor (IC₅₀=20 μM). CPP11G is promising for research of inflammatory diseases (e.g., vasculitis, atherosclerosis) and Nox2-overactivated pathologies (e.g., ischemia-reperfusion injury) .

HY-181176

DEMAMP	NADPH Oxidase SARS-CoV Virus Protease	Infection Inflammation/Immunology
DEMAMP is an antioxidant. DEMAMP exhibits scavenging effects on DPPH and H₂O₂ free radicals, with IC₅₀ values of 0.60 and 0.48 mg/mL, respectively. Molecular docking simulations show that DEMAMP potently inhibits *NADPH* oxidase and the Mpro and RdRp proteins of SARS-CoV-2, and ADMET analysis confirms that it has favorable oral bioavailability. DEMAMP can be used in studies related to COVID-19 .

Cat. No.	Product Name	Target	Research Area