2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. NADPH Oxidase Reactive Oxygen Species (ROS)
  4. GLX481372

GLX481372 is a NADPH Oxidase (NOX) inhibitor. GLX481372 potently inhibits NOX4/5 activities with IC50 values of 0.68 and 0.57 μM. GLX481372 also has weak inhibitory activity against NOX1, NOX2, and NOX3, with IC50 values of 7, 16 and 3.2 μM respectively. GLX481372 can inhibit ROS production. GLX481372 can be used for the researches of inflammation, cardiovascular and metabolic disease, such as diabetes.

For research use only. We do not sell to patients.

GLX481372

GLX481372 Chemical Structure

CAS No. : 1990478-58-4

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GLX481372 Related Antibodies

Top Publications Citing Use of Products

View All NADPH Oxidase Isoform Specific Products:

View All Isoforms
NOX1 NOX2 NOX4 NOX5 DUOX1

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Description

GLX481372 is a NADPH Oxidase (NOX) inhibitor. GLX481372 potently inhibits NOX4/5 activities with IC50 values of 0.68 and 0.57 μM. GLX481372 also has weak inhibitory activity against NOX1, NOX2, and NOX3, with IC50 values of 7, 16 and 3.2 μM respectively. GLX481372 can inhibit ROS production. GLX481372 can be used for the researches of inflammation, cardiovascular and metabolic disease, such as diabetes[1].

IC50 & Target[1]

NOX5

0.57 μM (IC50)

NOX4

0.68 μM (IC50)

NOX3

3.2 μM (IC50)

NOX1

7 μM (IC50)

NOX2

16 μM (IC50)

Molecular Weight

403.52

Formula

C23H29N7
CAS No.
SMILES

CC1=CC(NC2=NC(N)=NC(CN3CCN(CC3)C4=CC=C(C)C=C4)=N2)=CC=C1C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GLX481372 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLX4813721990478-58-4GLX 481372GLX-481372NADPH OxidaseReactive Oxygen Species (ROS)NOXInhibitorinhibitorinhibit

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