1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. 1,5-Isoquinolinediol

1,5-Isoquinolinediol 

Cat. No.: HY-W015422
Handling Instructions

1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina.

For research use only. We do not sell to patients.

1,5-Isoquinolinediol Chemical Structure

1,5-Isoquinolinediol Chemical Structure

CAS No. : 5154-02-9

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Description

1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2].

IC50 & Target[1]

PARP

0.18-0.37 μM (IC50)

In Vitro

1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene[1].
1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina. 1,5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina[2].

Molecular Weight

161.16

Formula

C₉H₇NO₂

CAS No.

5154-02-9

SMILES

O=C1NC=CC2=C1C=CC=C2O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 37.04 mg/mL (229.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.2050 mL 31.0251 mL 62.0501 mL
5 mM 1.2410 mL 6.2050 mL 12.4100 mL
10 mM 0.6205 mL 3.1025 mL 6.2050 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

1,5-IsoquinolinediolPARPpoly ADP ribose polymerasediabeticretinopathyoxidativestressNADPHoxidaseInhibitorinhibitorinhibit

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1,5-Isoquinolinediol
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HY-W015422
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