1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP

AZD-2461 

Cat. No.: HY-13536 Purity: 98.12%
Data Sheet SDS Handling Instructions

AZD2461 is a novel PARP inhibitor, which has the potential to avoid the olaparib resistence mediated by Pgp.

For research use only. We do not sell to patients.
AZD-2461 Chemical Structure

AZD-2461 Chemical Structure

CAS No. : 1174043-16-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $119 In-stock
5 mg $108 In-stock
10 mg $175 In-stock
50 mg $495 In-stock
100 mg $765 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

AZD2461 is a novel PARP inhibitor, which has the potential to avoid the olaparib resistence mediated by Pgp. IC50 Value: Target: PARP in vitro: in vivo: AZD2461 has an 80-fold increased Mdr1b expression on Olaparib-resistant KB1P tumor T6-28, without inhibition of Pgp. AZD2461 induces loss of 53BP1 expression in mice with KB1P tumors with short-term treatment. Long-term AZD2461 treatment is well tolerated and doubled the median relapse-free survival. Clinical trial: An Open-Label, Dose-Escalation Study of AZD-2461 .Phase 1 cpmpleted

Clinical Trial
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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.5289 mL 12.6445 mL 25.2889 mL
5 mM 0.5058 mL 2.5289 mL 5.0578 mL
10 mM 0.2529 mL 1.2644 mL 2.5289 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

395.43

Formula

C₂₂H₂₂FN₃O₃

CAS No.

1174043-16-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.12%

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Product Name:
AZD-2461
Cat. No.:
HY-13536
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