Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review

  • Bioorg Med Chem. 2019 Sep 15;27(18):3979-3997. doi: 10.1016/j.bmc.2019.07.050.
Jaiprakash Sangshetti  1 ,  Shahebaaz K Pathan  2 ,  Rajesh Patil  3 ,  Siddique Akber Ansari  4 ,  Santosh Chhajed  5 ,  Rohidas Arote  6 ,  Devanand B Shinde  7
Affiliations
  • 1. Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Baugh, Aurangabad, MS, India. Electronic address: [email protected].
  • 2. Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Baugh, Aurangabad, MS, India.
  • 3. Sinhgad Technical Education Society's, Smt. Kashibai Navale College of Pharmacy, Kondhwa (Bk), Pune, India.
  • 4. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, PO Box 2454, Riyadh 11451, Saudi Arabia.
  • 5. Department of Pharmaceutical Chemistry, Bhujbal Knowledge City, MET Institute of Pharmacy Adgaon, Nashik, India.
  • 6. Department of Molecular Genetics & Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea.
  • 7. Shivaji University Kolhapur, MS, India.
PMID: 31401008 DOI: 10.1016/j.bmc.2019.07.050
Abstract

Phthalazine, a structurally and pharmacologically versatile nitrogen-containing heterocycle, has gained more attention from medicinal chemists in the design and synthesis of novel drugs owing to its pharmacological potential. In particular, phthalazine scaffold appeared as a pharmacophoric feature numerous drugs exhibiting pharmacological activities, in particular, antidiabetic, Anticancer, antihypertensive, antithrombotic, anti-inflammatory, analgesic, antidepressant and antimicrobial activities. This review presents a summary of updated and detailed information on phthalazine as illustrated in both patented and non-patented literature. The reported literature have described the optimal pharmacological characteristics of phthalazine derivatives and highlighted the applicability of phthalazine, as potent scaffold in drug discovery.

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