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PD-1/PD-L1 inhibitory peptide C8

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By Targets:	PD-1/PD-L1 (3) Peptide-Drug Conjugates (PDCs) (1) Akt (2) Amino Acid Derivatives (1) Aminoacyl-tRNA Synthetase (1) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (5) Antibiotic (2) Autophagy (4) Bacterial (7) Biochemical Assay Reagents (2) c-Fms (1) CaMK (6) CDK (4) CXCR (1) Dipeptidyl Peptidase (1) DNA Alkylator/Crosslinker (1) Drug Intermediate (1) Dynamin (4) Endogenous Metabolite (2) Fungal (2) Gap Junction Protein (1) GCGR (1) GLP Receptor (7) HIV (4) iGluR (1) Influenza Virus (1) Insulin Receptor (15) Integrin (3) Interleukin Related (1) Ligands for E3 Ligase (1) Melanocortin Receptor (1) Na+/Ca2+ Exchanger (1) nAChR (1) NF-κB (2) NO Synthase (6) PAK (1) PKC (3) PKG (2) Prostaglandin Receptor (1) Ras (1) Reverse Transcriptase (1) TGF-beta/Smad (5) TNF Receptor (1) Toll-like Receptor (TLR) (1) TREM receptor (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (13) Endocrinology (2) Infection (17) Inflammation/Immunology (7) Metabolic Disease (22) Neurological Disease (16)
Click Chemistry:	Alkynes (1)

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Targets Recommended: PD-1/PD-L1 Macrophage migration inhibitory factor (MIF) RXFP Receptor Formyl Peptide Receptor (FPR) Peptide-Drug Conjugates (PDCs) Natriuretic Peptide Receptor (NPR) Connective Peptide CGRP Receptor Amyloid-β

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0276

GIP, human 2 Publications Verification Gastric inhibitory peptide (GIP), human	Insulin Receptor	Metabolic Disease
GIP, human, a peptide hormone consisting of 42 amino acids, is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP, human acts as an incretin hormone released from intestinal K cells in response to nutrient ingestion .

HY-P0276A

GIP, human TFA 2 Publications Verification Gastric inhibitory peptide (GIP), human TFA	Insulin Receptor	Metabolic Disease
GIP, human TFA, a peptide hormone consisting of 42 amino acids, is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP, human TFA acts as an incretin hormone released from intestinal K cells in response to nutrient ingestion .

HY-W012479

H-D-Trp-OH 1 Publications Verification D-Tryptophan	Endogenous Metabolite Ligands for E3 Ligase	Metabolic Disease
H-D-Trp-OH (D-Tryptophan) is the D-isomer of tryptophan, which is occasionally found in natural peptides, such as marine toxin peptides. H-D-Trp-OH can increase intestinal microbial diversity and counteract the inhibitory effect of allergic airway inflammation on intestinal microbial diversity .

HY-P10476

*Myostatin inhibitory* peptide 2**	TGF-beta/Smad	Others
Myostatin inhibitory peptide 2 (compd 2) is a myostatin inhibitor with a K_d of 35.9 nM. Myostatin inhibitory peptide 2 can be used for researches of muscle atrophic disorders .

HY-P3579

*Gastric Inhibitory* Peptide, porcine** GIP (1-42), porcine	Insulin Receptor	Metabolic Disease
Gastric Inhibitory Peptide (GIP (1-42)), porcine is a porcine glucose-dependent insulinotropic polypeptide and inhibitor of pentagastrin-stimulated gastric acid secretion. Gastric Inhibitory Peptide, porcine stimulates endogenous somatostatin release. Gastric Inhibitory Peptide, porcine acts in a dose- and time-dependent manner in conscious, chronic gastric fistula-equipped rats .

HY-P0322

GRGDSPK EMD 56574	Integrin	Cardiovascular Disease Metabolic Disease
GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption .

HY-W008876

Fmoc-Pen(Trt)-OH	Amino Acid Derivatives Drug Intermediate Biochemical Assay Reagents	Others
Fmoc-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize the inhibitory cystine knot (ICK) peptide ProTx-II .

HY-P11271

Ribupatide	Insulin Receptor GLP Receptor	Metabolic Disease
Ribupatide is a dual *gastric inhibitory* polypeptide (GIP) and glucagon-like peptide 1 (GLP-1)** receptor agonist. Enicepatide can be studied in antidiabetic research .

HY-P10242

*Myostatin inhibitory* peptide 7**	TGF-beta/Smad	Others
Myostatin inhibitory peptide 7 is a 23 amino acids peptide, which is derived from amino acids 21 to 43 of the mouse myostatin prodomain. Myostatin inhibitory peptide 7 inhibits myostatin with a K_d of 29.7 nM. Myostatin inhibitory peptide 7 can be used for researches of muscle atrophic disorders .

HY-P10816

*PACE4 Inhibitory* peptide C23** Ac-(DLeu)LLLRVK-Amba	Bacterial	Infection Cancer
PACE4 Inhibitory peptide C23 (Compound C23; Ac-(DLeu)LLLRVK-Amba)), a potent peptidomimetic inhibitor, is a PACE4 inhibitor. PACE4 Inhibitory peptide C23e shows antiproliferative effects against PCa cell lines (K_i = 5 nM; IC₅₀ = 25 and 40 μM for DU145 and LNCaP, respectively). PACE4 Inhibitory peptide C23 also blocks tumor growth in vivo in LNCaP xenograft-bearing mice .

HY-P10086

*TREM-1 inhibitory* peptide GF9** 1 Publications Verification Human TREM-1(213-221)	TREM receptor TNF Receptor Interleukin Related c-Fms	Neurological Disease Inflammation/Immunology Cancer
TREM-1 inhibitory peptide GF9 (Human TREM-1 (213-221)) is a TREM-1 inhibitor. TREM-1 inhibitory peptide GF9 blocks the TREM-1 signaling pathway via a ligand-independent mechanism, spontaneously inserts into the cell membrane to dissociate TREM-1 from DAP-12, and functions through the Signaling Chain Homooligomerization (SCHOOL) model. TREM-1 inhibitory peptide GF9 reduces the levels of TNFα, IL-1β, IL-6, and M-CSF. TREM-1 inhibitory peptide GF9 inhibits tumor growth, prolongs the survival of mice with pancreatic cancer models, ameliorates collagen-induced arthritis, and exerts protective effects on bone and cartilage simultaneously. TREM-1 inhibitory peptide GF9 can be used in research related to arthritis, pancreatic cancer, retinopathy, alcoholic liver disease, and liver cancer .

HY-112862

Arg-AMS 1 Publications Verification	Aminoacyl-tRNA Synthetase	Infection
Arg-AMS (compound 24) is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes .

HY-P10440

Cdk5i peptide	CDK	Neurological Disease
Cdk5i peptide is a CDK5 inhibitory peptide with high binding affinity for Cdk5/p25 (K_d of 0.17 μM), which can block the interaction between CDK5 and p25 and reduce the kinase activity of CDK5/p25. Cdk5i peptide can be used in the stud y of neurodegenerative diseases .

HY-P1369

*DynaMin inhibitory* peptide, myristoylated** 1 Publications Verification	Dynamin	Neurological Disease
DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated is a membrane-permeant form of the peptide that prevents endocytosis .

HY-P10950A

*PD-L1 inhibitory* peptide TFA**	PD-1/PD-L1	Inflammation/Immunology Cancer
PD-L1 inhibitory peptide TFA is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). PD-L1 inhibitory peptide TFA binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide TFA is promising for research of cancers .

HY-P4420

H-Lys-Trp-OH	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Lys-Trp-OH (KW) is an ACE inhibitory peptide with an IC₅₀ of 7.8 μM .

HY-P1083

Dynamin inhibitory peptide 1 Publications Verification	Dynamin	Neurological Disease
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors .

HY-P0215

*Autocamtide-2-related inhibitory* peptide, myristoylated**	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide, myristoylated is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM .

HY-P0214A

*Autocamtide-2-related inhibitory* peptide TFA** 2 Publications Verification	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide (TFA) is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

HY-P3580A

*Acetyl Gastric Inhibitory* Peptide (human) TFA** Human N-acetyl GIP TFA	Insulin Receptor	Metabolic Disease Endocrinology
Acetyl Gastric Inhibitory Peptide (human) TFA is a fatty acid derivatized analog of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Acetyl Gastric Inhibitory Peptide (human) TFA can be used for research of diabetes, insulin resistance and obesity .

HY-P3584A

(Pro3) GIP, human TFA (Pro3) Gastric inhibitory peptide, human TFA	Insulin Receptor	Metabolic Disease
(Pro3) GIP, human TFA is an efficacious, stable and specific human GIP receptor (hGIPR) full agonist. (Pro3) GIP, human TFA has high binding affinity for human GIPR with K_i/ K_d value of 0.90 nM. (Pro3) GIP, human TFA human can be used for the research of obesity-related diabetes .

HY-E70421

Peptide ligase	Angiotensin Receptor	Others
Butelase 1 ligase can be used for the cyclization of food-derived angiotensin I converting enzyme (ACE) inhibitory peptides, and thus improves the stability and bioactivity of ACE inhibitory peptides .

HY-P0142A

DT-3 acetate	PKG	Cardiovascular Disease
DT-3 acetate is a membrane-permeable protein kinase G Iα (PKG Iα) inhibitory peptide and shows pharmacological blockade of the cGMP-PKG signalling .

HY-P3985

Bradykinin potentiator B Bradykinin potentiating peptide B	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Others
Bradykinin potentiator B (Bradykinin potentiating peptide B) is venom of Agkistrodon halys blomhoffi. Bradykinin potentiator B is a potent ACE inhibitor. Bradykinin potentiator inhibits the activity of bradykinin inhibitory peptidase .

HY-E70397A

Dipeptidyl Peptidase IV, Porcine Kidney DPP-IV, Porcine Kidney	Dipeptidyl Peptidase	Metabolic Disease
Dipeptidyl Peptidase IV, Porcine Kidney (DPP-IV, Porcine Kidney) is a serine aminopeptidase with multiple physiological roles. Dipeptidyl Peptidase IV, Porcine Kidney hydrolyses gastric inhibitory peptide (GIP) and glucagon-like peptide 1 (GLP-1), the most important insulin-releasing hormones (incretins) of the enteroinsular axis .

HY-P10950

PD-L1 inhibitory peptide	PD-1/PD-L1	Inflammation/Immunology Cancer
PD-L1 inhibitory peptide is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). PD-L1 inhibitory peptide binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide is promising for research of cancers .

HY-P3730

*Cdk2/Cyclin Inhibitory* Peptide I**	CDK	Cancer
Cdk2/Cyclin Inhibitory Peptide I (Tat-LFG), a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner .

HY-P10634

P17 Peptide	TGF-beta/Smad	Others
P17 Peptide is a human TGF-β1 inhibitory peptide. P17 Peptide can block woodchuck TGF-β1 activity .

HY-P3395

Catestatin (human) Human chromogranin A 352–372	nAChR	Cardiovascular Disease Inflammation/Immunology
Catestatin human, a catecholamine release-inhibitory peptide, is a pleiotropic peptide involved in cardiovascular protection with its antihypertensive and angiogenic effects. Catestatin human can be used in the study of inflammatory diseases .

HY-P10591

Olatorepatide Olatorepatidum	Insulin Receptor GLP Receptor	Metabolic Disease
Olatorepatide (Olatorepatidum) is a dual gastric inhibitory polypeptide (GIP) receptor and glucagon like peptide 1 (GLP-1) receptor agonist, with antidiabetic effect .

HY-P11271A

Ribupatide TFA	Insulin Receptor GLP Receptor	Metabolic Disease
Ribupatide TFA is a dual *gastric inhibitory* polypeptide (GIP) and glucagon-like peptide 1 (GLP-1)** receptor agonist. Ribupatide TFA can be studied in antidiabetic research .

HY-P1847A

*IKKγ NBD Inhibitory* Peptide TFA**	NF-κB	Inflammation/Immunology
IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-P10383

*SPSB2-iNOS inhibitory* cyclic peptide-1**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

HY-P0214

Autocamtide-2-related inhibitory peptide	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

HY-P3584

(Pro3) GIP, human (Pro3) Gastric inhibitory peptide, human	Insulin Receptor	Metabolic Disease
(Pro3) GIP, human ((Pro3) Gastric Inhibitory Peptide, human) is an efficacious, stable and specific human GIP receptor (hGIPR) full agonist. (Pro3) GIP, human has high binding affinity for human GIPR with K_i/ K_d values of 0.90 nM. (Pro3) GIP, human can be used for the research of obesity-related diabetes .

HY-P11003

PTD-N5-1	Toll-like Receptor (TLR)	Inflammation/Immunology
PTD-N5-1 (N5-1) is an IRF5 inhibitory peptide. PTD-N5-1 blocks β-glucan-induced IL-12 production in IFN-γ primed wild-type and Clec2d-difecient bone-marrow-derived dendritic cells (BMDCs). PTD-N5-1 regulates antifungal immunity through suppression of IRF5-mediated IL-12 production .

HY-P3429

SAMβA	PKC	Cardiovascular Disease
SAMβA is conjugated to the cell permeable peptide TAT47-57. SAMβA, a rationally designed selective antagonist of Mfn1-βIIPKC association. SAMβA is a selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats .

HY-P3429A

SAMβA TFA	PKC	Cardiovascular Disease
SAMβA TFA is a rationally designed selective antagonist of Mfn1-βIIPKC association and can bind to TAT (HY-P0281). SAMβA TFA is a selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats .

HY-P11237

Enicepatide CT-388	GCGR Insulin Receptor	Metabolic Disease
Enicepatide is a dual *gastric inhibitory* polypeptide (GIP) and glucagon-like peptide 1 (GLP-1)** receptor agonist. Enicepatide can be studied in antidiabetic research .

HY-P0142

DT-3	PKG	Cardiovascular Disease
DT-3 is a membrane-permeable protein kinase G Iα (PKG Iα) inhibitory peptide and shows pharmacological blockade of the cGMP-PKG signalling .

HY-P11270

Relsipatide BGM0504; BG128	Insulin Receptor GLP Receptor	Metabolic Disease
Relsipatide (BG128) is a dual *gastric inhibitory* polypeptide (GIP) and glucagon-like peptide 1 (GLP-1)** receptor agonist. Enicepatide can be studied in antidiabetic research .

HY-P10242A

*Myostatin inhibitory* peptide 7 TFA**	TGF-beta/Smad	Others
Myostatin inhibitory peptide 7 TFA is a 23 amino acids peptide, which is derived from amino acids 21 to 43 of the mouse myostatin prodomain. Myostatin inhibitory peptide 7 TFA inhibits myostatin with a K_d of 29.7 nM. Myostatin inhibitory peptide 7 TFA can be used for researches of muscle atrophic disorders .

HY-P10476A

*Myostatin inhibitory* peptide 2 TFA**	TGF-beta/Smad	Others
Myostatin inhibitory peptide 2 (compd 2) TFA is a myostatin inhibitor with a K_d of 35.9 nM. Myostatin inhibitory peptide 2 TFA can be used for researches of muscle atrophic disorders .

HY-114437

Fusion Inhibitory Peptide Z-D-Phe-Phe-Gly-OH; FIP; Virus Replication inhibitory peptide	Influenza Virus	Infection
Fusion Inhibitory Peptide (Z-D-Phe-Phe-Gly-OH, FIP, Virus Replication Inhibitory Peptide) is a potent inhibitor of the virus replication, by inhibiting the membrane fusing activity of a viral glycoprotein .

HY-P1847

IKKγ NBD Inhibitory Peptide	NF-κB	Cancer
IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-P3580

*Acetyl Gastric Inhibitory* Peptide (human)** Human N-acetyl GIP	Insulin Receptor	Metabolic Disease Endocrinology
Acetyl Gastric Inhibitory Peptide (human) is a fatty acid derivatized analog of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Acetyl Gastric Inhibitory Peptide (human) can be used for research of diabetes, insulin resistance and obesity .

HY-P10071

*CaMKII inhibitory* peptide KIIN** Calmodulin Kinase IINtide; CaM-KIIN; CaM-KIINβ	CaMK	Others
CaMKII inhibitory peptide KIIN is a potent inhibitor of CaMKII .

HY-103545

GIP (1-39) Gastric inhibitory peptide (1-39) (porcine)	Insulin Receptor	Metabolic Disease
GIP (1-39) (Gastric inhibitory peptide (1-39) (porcine)) is an insulinotropic peptide that stimulats insulin secretion from rat pancreatic islets. GIP (1-39) at 100 nM was able to significantly increase intracellular Ca ²⁺ concentration ([Ca ²⁺]_i), and capable of enhancing exocytosis .

HY-P5525

AC3-I, myristoylated Autocamtide-3 Derived inhibitory peptide	CaMK	Others
AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)

HY-P5038

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) c(GRGDSP)	Integrin	Cancer
Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 integrin ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells .

Cat. No.	Product Name		Classification

HY-P10950

PD-L1 inhibitory peptide		Alkynes
PD-L1 inhibitory peptide is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). PD-L1 inhibitory peptide binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide is promising for research of cancers .

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PD-1/PD-L1 inhibitory peptide C8

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