1. PI3K/Akt/mTOR
  2. Akt
  3. AKTide-2T

AKTide-2T 

Cat. No.: HY-P1115
Handling Instructions

AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position.

For research use only. We do not sell to patients.

AKTide-2T Chemical Structure

AKTide-2T Chemical Structure

CAS No. : 324029-01-8

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Description

AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1].

IC50 & Target[1]

Akt

 

In Vitro

AKTide-2T mimics the optimal phosphorylation sequence of Akt, and inhibits Akt phosphorylated Hsp27 by addition of 20 μM Akt inhibitory peptide[1].

Molecular Weight

1715.87

Formula

C₇₄H₁₁₄N₂₈O₂₀

CAS No.

324029-01-8

Sequence

Ala-Arg-Lys-Arg-Glu-Arg-Thr-Tyr-Ser-Phe-Gly-His-His-Ala

Sequence Shortening

ARKRERTYSFGHHA

SMILES

[ARKRERTYSFGHHA]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AKTide-2TAktPKBProtein kinase BAkt Substratehistone H2B AKTideinhibitory peptideInhibitorinhibitorinhibit

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AKTide-2T
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