2. GPCR/G Protein
  3. GLP Receptor
  4. Brenipatide

Brenipatide (LY-3537031) is a dual glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) receptor agonist. Brenipatide can be used for the study of metabolic disorders, obesity and diabetes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Brenipatide

Brenipatide Chemical Structure

CAS No. : 2408921-49-1

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Based on 1 publication(s) in Google Scholar

Brenipatide Related Antibodies

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Description

Brenipatide (LY-3537031) is a dual glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) receptor agonist. Brenipatide can be used for the study of metabolic disorders, obesity and diabetes[1].

Clinical Trial
Molecular Weight

4891.52

Formula

C228H354N46O72
CAS No.
Appearance

Solid

Color

White to light yellow

Sequence

{d-Tyr}-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Leu(aMe)}-Leu-Asp-Lys-{Lys(AEEA-AEEA-γGlu-C20 diacid)}-Ala-Gln-{Aib}-Glu-Phe-Ile-Glu-{Tyr(aMe)}-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Sequence Shortening

{d-Tyr}-{Aib}-EGTFTSDYSI-{Leu(aMe)}-LDK-{K(AEEA-AEEA-γGlu-C20 diacid)}-AQ-{Aib}-EFIE-{Tyr(aMe)}-LIAGGPSSGAPPPS-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (20.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2044 mL 1.0222 mL 2.0444 mL
5 mM 0.0409 mL 0.2044 mL 0.4089 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2044 mL 1.0222 mL 2.0444 mL 5.1109 mL
5 mM 0.0409 mL 0.2044 mL 0.4089 mL 1.0222 mL
10 mM 0.0204 mL 0.1022 mL 0.2044 mL 0.5111 mL
15 mM 0.0136 mL 0.0681 mL 0.1363 mL 0.3407 mL
20 mM 0.0102 mL 0.0511 mL 0.1022 mL 0.2555 mL
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Brenipatide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brenipatide2408921-49-1LY-3537031LY3537031LY 3537031GLP ReceptorGLP-1R/GIPR agonistmetabolic disordersobesity and diabetesInhibitorinhibitorinhibit

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