Cdk5i peptide
Based on 1 Customer Validation
Cdk5i peptide is a CDK5 inhibitory peptide with high binding affinity for Cdk5/p25 (Kd of 0.17 μM), which can block the interaction between CDK5 and p25 and reduce the kinase activity of CDK5/p25. Cdk5i peptide can be used in the stud y of neurodegenerative diseases.
For research use only. We do not sell to patients.
- Purity: 98.93%
- CAS No.: 2298317-00-5
- Formula: C60H94N18O15S
- Molecular Weight:1339.56
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cdk5/p25 0.17 μM (Kd) |
CDK5 15.72 μM (Kd) |
Cdk5i peptide consists of 12 amino acids (ARAFGIPVRCYS) derived from the CDK5 T loop. This 12-amino-acid sequence is highly conserved in CDK5 across species, yet not present in other Cdk family members[1].
Cdk5i peptide binds to the Cdk5/p25 complex with more than 92-fold higher affinity than to Cdk5 alone (Kd = 0.17 μM vs. Kd = 15.72 μM)[1].
Study using co-expressed Cdk5/p25 and Cdk5i peptides in HEK293T cells. Western blot analysis confirmed that coexpression of Cdk5i peptide does not change the amounts of Cdk5 and p25 protein present in cells. However, Cdk5i peptide coexpression does reduce both the interaction of Cdk5 with p25 (~25%) and Cdk5 kinase activity (~27%), while it did not significantly impact the kinase activity of Cdk5/p35 and Cdk1/Cyclin A complexes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2298317-00-5
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Appearance Solid
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Molecular Weight 1339.56
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Formula C60H94N18O15S
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Color White to off-white
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Sequence
Ala-Arg-Ala-Phe-Gly-Ile-Pro-Val-Arg-Cys-Tyr-Ser
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Sequence Shortening
ARAFGIPVRCYS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 2 mg/mL (1.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7465 mL | 3.7326 mL | 7.4651 mL | 18.6628 mL |
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