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Cat. No.: HY-P3580

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Acetyl Gastric Inhibitory Peptide (human)

Name: Acetyl Gastric Inhibitory Peptide (human)
Brand: MedChemExpress
SKU: HY-P3580
Availability: PreOrder

(Synonyms: Human N-acetyl GIP)

Acetyl Gastric Inhibitory Peptide (human) is a fatty acid derivatized analog of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Acetyl Gastric Inhibitory Peptide (human) can be used for research of diabetes, insulin resistance and obesity.

For research use only. We do not sell to patients.

CAS No.: 299898-33-2
Formula: C₂₂₈H₃₄₀N₆₀O₆₇S
Molecular Weight:5025.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Acetyl Gastric Inhibitory Peptide (human) Chemical Structure

CAS No.: 299898-33-2

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Classifications
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Biological Activity

Description

In Vitro

Acetyl Gastric Inhibitory Peptide (human) induces cyclic adenosine 3'5' monophosphate (cAMP) production with an EC₅₀ value of 1.9 nM in Chinese hamster lung fibroblast cells transfected with the human GIP receptor^[1].
Acetyl Gastric Inhibitory Peptide (human) (10^-13-10^-8 nM) shows potent effect at stimulating insulin release compared to the native GIP in BRIN-BD11 cells^[1].
Acetyl Gastric Inhibitory Peptide (human) improves glucose intolerance, type 2 diabetes, beta-cell glucose insensitivity, insulin resistance and reduced insulin secretion^[2].
Acetyl Gastric Inhibitory Peptide (human) has metabolic stability and hypoglycemic and insulin modulating activities of two fatty acid derivatized N-terminally acetylated GIP analogs were evaluated in in vitro and in vivo^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Acetyl Gastric Inhibitory Peptide (human) (25 nmol/kg; i.p.; single dose) shows resistance to plasma dipeptidylpeptidase IV degradation, resulting in enhanced biological activity and improved antidiabetic potential in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Obese hyperglycaemic (ob/ob) mice^[1]
Dosage:

25 nmol/kg
Administration:

Intraperitoneal injection; single dose
Result:

Lowered individual glucose values at 60 min together with the areas under the curve for glucose compared to native GIP.

Chemical Information

CAS No. 299898-33-2
Molecular Weight 5025.60
Formula C₂₂₈H₃₄₀N₆₀O₆₇S
Synonyms

Human N-acetyl GIP
Sequence

Ac-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln
Sequence Shortening

Ac-YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. O'Harte FP, et al. Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP. Diabetologia. 2002 Sep;45(9):1281-91. [Content Brief]

[2]. Gault Victor A, et al. GIP peptide analogues for treatment of diabetes, insulin resistance and obesity: World Intellectual Property Organization, WO2005082928[P]. 2005-12-01.

[3]. O'Harte, et al. Analogs of gastric inhibitory polypeptide as a treatment for age related decreased pancreatic beta cell function: World Intellectual Property Organization, WO2007028632[P].2007-03-15.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Acetyl Gastric Inhibitory Peptide (human)

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Biological Activity
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- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Acetyl Gastric Inhibitory Peptide (human)

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Acetyl Gastric Inhibitory Peptide (human) Related Classifications

HY-P3580 Related Classifications

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