Cat. No.: HY-W012479

H-D-Trp-OH

(Synonyms: D-Tryptophan)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

H-D-Trp-OH (D-Tryptophan) is the D-isomer of tryptophan, which is occasionally found in natural peptides, such as marine toxin peptides. H-D-Trp-OH can increase intestinal microbial diversity and counteract the inhibitory effect of allergic airway inflammation on intestinal microbial diversity.

For research use only. We do not sell to patients.

Purity: 99.97%
CAS No.: 153-94-6
Formula: C₁₁H₁₂N₂O₂
Molecular Weight:204.23

Storage:

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

H-D-Trp-OH Chemical Structure

CAS No.: 153-94-6

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

All Ligands for E3 Ligase Isoforms :

In Vitro

H-D-Trp-OH (D-Tryptophan) in probiotics affects the gut microbiota and allergic airway disease. Allergic airway inflammation reduces gut microbial diversity, while D-Tryptophan increases gut microbial diversity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

H-D-Trp-OH (D-Tryptophan) (~0.09 or ~0.9 mg/day/mouse; p.o. in drinking water; 3 d) can prevent experimental asthma models in mice, increase the number of regulatory T cells in the lung and intestine, reduce lung TH2 responses, and improve allergic airway inflammation and hyperresponsiveness^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 153-94-6
Appearance Solid
Molecular Weight 204.23
Formula C₁₁H₁₂N₂O₂
Color White to off-white
SMILES

O=C(O)[C@H](N)CC1=CNC2=CC=CC=C12
Synonyms

D-Tryptophan
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
- Marine natural products
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Publications (1)

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227

Solvent & Solubility

In Vitro:

1 M HCl : 50 mg/mL (244.82 mM; Need ultrasonic)

0.1 M HCl : 25 mg/mL (122.41 mM; ultrasonic and warming and heat to 60°C)

DMSO : 3.33 mg/mL (16.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.8964 mL

24.4822 mL

48.9644 mL

5 mM

0.9793 mL

4.8964 mL

9.7929 mL

10 mM

0.4896 mL

2.4482 mL

4.8964 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 0.33 mg/mL (1.62 mM); Clear solution

This protocol yields a clear solution of ≥ 0.33 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (3.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 0.33 mg/mL (1.62 mM); Clear solution

This protocol yields a clear solution of ≥ 0.33 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (3.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 0.33 mg/mL (1.62 mM); Clear solution

This protocol yields a clear solution of ≥ 0.33 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (3.3 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: Saline

Solubility: 5 mg/mL (24.48 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kepert I, et al. D-tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease. J Allergy Clin Immunol. 2017 May;139(5):1525-1535. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / 0.1 M HCl / 1 M HCl	1 mM	4.8964 mL	24.4822 mL	48.9644 mL	122.4110 mL
	5 mM	0.9793 mL	4.8964 mL	9.7929 mL	24.4822 mL
	10 mM	0.4896 mL	2.4482 mL	4.8964 mL	12.2411 mL
	15 mM	0.3264 mL	1.6321 mL	3.2643 mL	8.1607 mL
0.1 M HCl / 1 M HCl	20 mM	0.2448 mL	1.2241 mL	2.4482 mL	6.1206 mL
	25 mM	0.1959 mL	0.9793 mL	1.9586 mL	4.8964 mL
	30 mM	0.1632 mL	0.8161 mL	1.6321 mL	4.0804 mL
	40 mM	0.1224 mL	0.6121 mL	1.2241 mL	3.0603 mL
	50 mM	0.0979 mL	0.4896 mL	0.9793 mL	2.4482 mL
	60 mM	0.0816 mL	0.4080 mL	0.8161 mL	2.0402 mL
	80 mM	0.0612 mL	0.3060 mL	0.6121 mL	1.5301 mL
	100 mM	0.0490 mL	0.2448 mL	0.4896 mL	1.2241 mL

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H-D-Trp-OH

Metabolism/Protease Compound Library

Natural Product Library

Human Endogenous Metabolite Compound Library

Ubiquitination Compound Library

Traditional Chinese Medicine Active Compound Library

Gut Microbial Metabolite Library

Microbial Metabolite Library

Food-Sourced Compound Library

Human Metabolite Library

E3 Ligase Ligand Library

Marine-Sourced Natural Product Library

Animal-Sourced Natural Product Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Mass Spectrometry Natural Product Library

3D Diverse Fragment Library

Publications Citing Use of MedChemExpress (MCE) H-D-Trp-OH

All Endogenous Metabolite Isoforms

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

H-D-Trp-OH Related Classifications

HY-W012479 Related Classifications