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Cat. No.: HY-P0214

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Autocamtide-2-related inhibitory peptide

Name: Autocamtide-2-related inhibitory peptide
Brand: MedChemExpress
SKU: HY-P0214
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2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

For research use only. We do not sell to patients.

CAS No.: 167114-91-2
Formula: C₆₄H₁₁₆N₂₂O₁₉
Molecular Weight:1497.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Autocamtide-2-related inhibitory peptide Chemical Structure

CAS No.: 167114-91-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

IC₅₀ & Target

CaMK II

All CaMK Isoforms :

In Vitro

It is found that Autocamtide-2-related inhibitory peptide (a novel synthetic peptide ATP) is a potent inhibitor of CaM-kinase II with an IC₅₀ of 40 nM, which is active in the presence or absence of Ca²⁺/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93,respectively, under the assay condition used^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 167114-91-2
Molecular Weight 1497.74
Formula C₆₄H₁₁₆N₂₂O₁₉
Sequence

Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu
Sequence Shortening

KKALRRQEAVDAL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Nat Commun

TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection. [Abstract]

2021 Jun 10;12(1):3519. PMID: 34112781
Biomed Pharmacother

PIEZO1 as a new target for hyperglycemic stress-induced neuropathic injury: The potential therapeutic role of bezafibrate. [Abstract]

2024 Jul:176:116837. PMID: 38815290

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Autocamtide-2-related inhibitory peptide

2 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (2)
Purity & Documentation
References

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Autocamtide-2-related inhibitory peptide

Publications Citing Use of MedChemExpress (MCE) Autocamtide-2-related inhibitory peptide

All CaMK Isoforms