1. Neuronal Signaling
  2. CaMK
  3. KN-92 phosphate

KN-92 phosphate 

Cat. No.: HY-15517A Purity: 99.94%
Handling Instructions

KN-92 is an inactive derivative of KN-93.

For research use only. We do not sell to patients.

KN-92 phosphate Chemical Structure

KN-92 phosphate Chemical Structure

CAS No. : 1135280-28-2

Size Price Stock Quantity
2 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 330 In-stock
Estimated Time of Arrival: December 31
50 mg USD 980 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of KN-92 phosphate:

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). IC50 value: Target: KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : < 0.1 mg/mL (insoluble)

In Vivo:
  • 1.

    HY-15517A KN-92 is prepared in vehicle (0.9% saline)[7].

References
Molecular Weight

554.98

Formula

C₂₄H₂₈ClN₂O₇PS

CAS No.

1135280-28-2

SMILES

O=S(C1=CC=C(OC)C=C1)(NC2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)=O.O=P(O)(O)O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.94%

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Product Name:
KN-92 phosphate
Cat. No.:
HY-15517A
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KN-92 phosphate

Cat. No.: HY-15517A