1. Neuronal Signaling
  2. CaMK

KN-92 hydrochloride 

Cat. No.: HY-15517B Purity: 99.77%
Data Sheet SDS Handling Instructions

KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).

For research use only. We do not sell to patients.
KN-92 hydrochloride Chemical Structure

KN-92 hydrochloride Chemical Structure

CAS No. : 1431698-47-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 319 In-stock
2 mg USD 168 In-stock
5 mg USD 294 In-stock
10 mg USD 406 In-stock
50 mg USD 1182 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of KN-92 hydrochloride:

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Description

KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). IC50 value: Target: KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0265 mL 10.1327 mL 20.2655 mL
5 mM 0.4053 mL 2.0265 mL 4.0531 mL
10 mM 0.2027 mL 1.0133 mL 2.0265 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

493.45

Formula

C₂₄H₂₆Cl₂N₂O₃S

CAS No.

1431698-47-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
KN-92 hydrochloride
Cat. No.:
HY-15517B
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