KN-92 hydrochloride
Based on 11 publication(s) in Google Scholar
KN-92 hydrochloride is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 hydrochloride is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 1431698-47-3
- Formula: C24H26Cl2N2O3S
- Molecular Weight:493.45
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) KN-92 hydrochloride
More- Nat Metab. 2020 Sep;2(9):918-933. [Abstract]
- Br J Anaesth. 2026 Jan 27:S0007-0912(25)00893-1. [Abstract]
- Curr Biol. 2026 May 4;36(9):2367-2381.e9. [Abstract]
- Brain Behav Immun. 2026 Mar 6:135:106529. [Abstract]
- Commun Biol. 2025 Mar 12;8(1):417. [Abstract]
- J Endocrinol. 2018 Mar;236(3):151-165. [Abstract]
- Sci Rep. 2023 Dec 7;13(1):21712. [Abstract]
- J Mol Cell Cardiol. 2022 Mar:164:110-125. [Abstract]
- Cell Calcium. 2021 Dec:100:102483. [Abstract]
- Proteomics. 2026 May;26(5):69-85. [Abstract]
- UCSF. 2025.
Biological Activity
KN-93 (5-50μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50μM; 24 hours) is ineffective in blocking cell growth[2].
The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduced the expression of p53 and p21[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human hepatic stellate cells (LX-2)
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Concentration:5-50 μM
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Incubation Time:24 hours
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Result:Ineffective in blocking cell growth.
Chemical Information
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CAS No. 1431698-47-3
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Appearance Solid
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Molecular Weight 493.45
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Formula C24H26Cl2N2O3S
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Color White to off-white
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SMILES
O=S(C1=CC=C(OC)C=C1)(NC2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (11)
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Journal Impact Factor
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Most Recent
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Nat Metab
AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury. [Abstract]2020 Sep;2(9):918-933. PMID: 32778834 -
Br J Anaesth
Sevoflurane alters α5β3GABAA receptor trafficking via calcium/calmodulin-dependent protein kinase II-dependent β3 subunit phosphorylation to produce cognitive impairment in aged mice. [Abstract]2026 Jan 27:S0007-0912(25)00893-1. PMID: 41605734 -
Curr Biol
2026 May 4;36(9):2367-2381.e9. PMID: 42025171 -
Brain Behav Immun
NR2B-CaMKII signaling in the dentate gyrus driven by astrocytic P2Y1Rs mediates the antidepressant effect of low-dose LPS. [Abstract]2026 Mar 6:135:106529. PMID: 41796645 -
Commun Biol
Piezo1 promotes the progression of necrotizing enterocolitis by activating the Ca2(+)/CaMKII-dependent pathway. [Abstract]2025 Mar 12;8(1):417. PMID: 40074811 -
J Endocrinol
2018 Mar;236(3):151-165. PMID: 29371236 -
Sci Rep
Hippocampal CaMKII inhibition induces reactivation-dependent amnesia for extinction memory and causes fear relapse. [Abstract]2023 Dec 7;13(1):21712. PMID: 38066022 -
J Mol Cell Cardiol
Ventricular SK2 upregulation following angiotensin II challenge: Modulation by p21-activated kinase-1. [Abstract]2022 Mar:164:110-125. PMID: 34774547 -
Cell Calcium
Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts. [Abstract]2021 Dec:100:102483. PMID: 34628110 -
Proteomics
Dynamic Phosphoproteomic Profiling Captured Early Signaling Events for Cold Acclimation in Larval Zebrafish. [Abstract]2026 May;26(5):69-85. PMID: 41906457 -
Solvent & Solubility
DMSO : 50 mg/mL (101.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.07 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277(38):35061-35070. [Content Brief]
[2]. An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13(9):1445-1448. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0265 mL | 10.1327 mL | 20.2655 mL | 50.6637 mL |
| 5 mM | 0.4053 mL | 2.0265 mL | 4.0531 mL | 10.1327 mL | |
| 10 mM | 0.2027 mL | 1.0133 mL | 2.0265 mL | 5.0664 mL | |
| 15 mM | 0.1351 mL | 0.6755 mL | 1.3510 mL | 3.3776 mL | |
| 20 mM | 0.1013 mL | 0.5066 mL | 1.0133 mL | 2.5332 mL | |
| 25 mM | 0.0811 mL | 0.4053 mL | 0.8106 mL | 2.0265 mL | |
| 30 mM | 0.0676 mL | 0.3378 mL | 0.6755 mL | 1.6888 mL | |
| 40 mM | 0.0507 mL | 0.2533 mL | 0.5066 mL | 1.2666 mL | |
| 50 mM | 0.0405 mL | 0.2027 mL | 0.4053 mL | 1.0133 mL | |
| 60 mM | 0.0338 mL | 0.1689 mL | 0.3378 mL | 0.8444 mL | |
| 80 mM | 0.0253 mL | 0.1267 mL | 0.2533 mL | 0.6333 mL | |
| 100 mM | 0.0203 mL | 0.1013 mL | 0.2027 mL | 0.5066 mL |
KN-92 hydrochloride Related Classifications
HY-15517B Related Classifications
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