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KN-92 

Cat. No.: HY-15517
Handling Instructions

KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor.

For research use only. We do not sell to patients.

KN-92 Chemical Structure

KN-92 Chemical Structure

CAS No. : 176708-42-2

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Description

KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2].

In Vitro

KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50 μM; 24 hours) is ineffective in blocking cell growth[2].
The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduces the expression of p53 and p21[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Human hepatic stellate cells (LX-2)
Concentration: 5-50 μM
Incubation Time: 24 hours
Result: Ineffective in blocking cell growth.
Molecular Weight

456.98

Formula

C₂₄H₂₅ClN₂O₃S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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KN-92
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HY-15517
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