Search Result
Results for "
ureas
" in MedChemExpress (MCE) Product Catalog:
2
Biochemical Assay Reagents
15
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-P2767
-
|
Bacterial
|
Others
|
Urease, Jack bean is derived from jack bean and Catalyzes hydrolysis of urea to carbon dioxide and ammonia. Urease, Jack bean is useful in the determination of urea in body fluids.
|
-
-
- HY-141536
-
-
-
- HY-118877
-
|
Isotope-Labeled Compounds
|
Infection
|
Urea- 13C is the 13C labelled urea. The Urea- 13C breath test ( 13C-UBT) is one of the best methods for the diagnosis of Helicobacter pylori infection[1].
|
-
-
- HY-123179
-
|
Others
|
Cardiovascular Disease
|
Mefruside is an orally active diuretic and has a mild hypotensive effect. Mefruside inhibits the synthesis of urea in an isolated rat liver perfusion model. Mefruside can be used in studies of oedema and hypertension .
|
-
-
- HY-B2020S
-
-
-
- HY-W017018
-
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Ornithine hydrochloride is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective .
|
-
-
- HY-B1352
-
(S)-2,5-Diaminopentanoic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Ornithine ((S)-2,5-Diaminopentanoic acid) is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine shows nephroprotective .
|
-
-
- HY-N0157
-
6-Carboxyuracil; Vitamin B13
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Metabolic Disease
|
Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats .
|
-
-
- HY-N0157A
-
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Metabolic Disease
|
Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats .
|
-
-
- HY-19353
-
SR7826
1 Publications Verification
|
LIM Kinase (LIMK)
|
Neurological Disease
Cancer
|
SR7826 is a class of bis-aryl urea derived potent, selective and orally active LIM kinase (LIMK) inhibitor with an IC50 of 43 nM for LIMK1. SR7826 is >100-fold more selective for LIMK1 than ROCK and JNK kinases .
|
-
-
- HY-144329
-
|
STING
|
Inflammation/Immunology
Cancer
|
STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of STING with EC50 of 18 nM. Activation of STING is a highly promising approach in immunotherapy .
|
-
-
- HY-144328
-
|
STING
|
Inflammation/Immunology
Cancer
|
STING agonist-10 (Compound 91) is a potent small molecule cyclic urea activator of STING with the EC50 of 2600 nM. Activation of STING is a highly promising approach in immunotherapy .
|
-
-
- HY-Y0271S1
-
1,1,3,3-Tetradeuteriourea; Urea-d4
|
Endogenous Metabolite
|
|
Urea-d4 is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
-
- HY-108379
-
|
ADC Linker
|
Cancer
|
Boc-C2-Urea-bis(Boc)-C4-Urea-4-phenylacetic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
-
- HY-Y0271S2
-
|
Endogenous Metabolite
|
|
Urea- 13C, 15N2 is the 13C and 15N labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
-
- HY-128129
-
|
Urea Transporter
|
Metabolic Disease
|
UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research .
|
-
-
- HY-W010382
-
2-Oxosuccinic acid
|
Endogenous Metabolite
Reactive Oxygen Species
|
Metabolic Disease
|
Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis, whereby Oxaloacetic acid facilitates the clearance of reactive oxygen species (ROS) and improves mitochondrial function .
|
-
-
- HY-P3190
-
L-Arginine amidinase
|
Endogenous Metabolite
|
Metabolic Disease
|
Arginase, Microorganism (L-Arginine amidinase) is an enzyme of the urea cycle. Arginase catalyzes the hydrolysis of L-arginine to L-ornithine and urea .
|
-
-
- HY-Y0271S
-
Carbamide-15N2; Carbonyldiamide-15N2
|
Endogenous Metabolite
|
Cardiovascular Disease
Cancer
|
Urea- 15N2 is the 15N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
-
- HY-135795
-
CDU; N-Cyclohexyl-N-dodecyl urea; NCND
|
Epoxide Hydrolase
|
Cardiovascular Disease
Metabolic Disease
|
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension .
|
-
-
- HY-W009350
-
|
Bacterial
|
Infection
|
Diazolidinyl urea, a broad spectrum preservative, is a formaldehyde-releasing compound that releases formaldehyde through its decomposition. Diazolidinyl urea is effective against most contaminating microorganisms, especially Pseudomonas .
|
-
-
- HY-147287
-
|
PSMA
|
Cancer
|
Glu-urea-Glu-NHS ester (compound 21) is an activated N-hydroxysuccinamide (NHS) ester of Glu-urea-Glu which can be used as a pharmacophore for linking with prostate specific membrane antigen (PSMA) inhibitors .
|
-
-
- HY-148573
-
-
-
- HY-B1158
-
|
Bacterial
|
Infection
|
Imidazolidinyl urea is an antibacterial preservative used in cosmetics as a formaldehyde releaser.
|
-
-
- HY-131964
-
|
Drug Metabolite
|
Others
|
Imidacloprid-urea is a metabolite of Imidacloprid. Imidacloprid is an effective and widely used neonicotinoid pesticide to control pests of cereals, vegetables, tea and cotton. Imidacloprid-urea can occupy or block adsorption sites of imidacloprid on soil, potentially affecting the fate, transport, and bioavailability of imidacloprid in the environment .
|
-
-
- HY-Y0271
-
Urea
1 Publications Verification
Carbonyl diamide
|
|
|
Urea is a powerful protein denaturant via both direct and indirect mechanisms . A potent emollient and keratolytic agent . Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function . Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
-
- HY-Y0470
-
Aminourea hydrochloride; Hydrazinecarboxamide hydrochloride
|
|
|
Semicarbazide hydrochloride, a derivative of urea, possesses antiviral, antiinfective and antineoplastic through binding to copper or iron in cells .
|
-
-
- HY-160013
-
|
FGFR
|
Cancer
|
FGFR-IN-12 (example 14), a pyrimidinyl aryl urea derivative, is a potent FGFR inhibitor .
|
-
-
- HY-43869
-
PSMA-617 Ligand-Linker Conjugate
|
ADC Linker
|
Cancer
|
Vipivotide tetraxetan Ligand-Linker Conjugate (PSMA-617 Ligand-Linker Conjugate) is a complex composed of pharmacophore group Glutamate-urea-Lysine peptide coupling linker, which can be used to synthesize Vipivotide tetraxetan (PSMA-617). Glutamate-urea-Lysine selectively binds to prostate-specific membrane antigen (PSMA) .
|
-
-
- HY-P5290
-
|
PSMA
|
Cancer
|
HYNIC-PSMA is a ligand for molecular imaging of tumors. Hynic-psma consists of two components: HYNIC (6-hydrazinonicotinamide) and PSMA (Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules, such as 188Re-HYNIC-PSMA. PSMA is a membrane antigen that is specifically expressed on the surface of prostate cancer cells. HYNIC-PSMA can be used in prostate cancer research .
|
-
-
- HY-P5292
-
|
PSMA
|
Cancer
|
HYNIC-iPSMA is a ligand for molecular imaging of tumors. Hynic-ipsma consists of two components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/HYNIC-iPSMA has excellent specificity and sensitivity .
|
-
-
- HY-134749
-
|
PROTAC Linkers
|
Cancer
|
Propargyl-PEG2-urea-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-PEG2-urea-C3-triethoxysilane is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
-
- HY-107199
-
NBPT
|
Bacterial
|
Others
|
N-Butylthiophosphoric triamide (NBPT) is a potent urease inhibitor. Butylthiophosphoric triamide inhibits nitrification and reduces the conversion of urea to NH3 gas .
|
-
-
- HY-P2893
-
Creatine amidohydrolase
|
Endogenous Metabolite
|
Others
|
Creatinase, Actinobacteria (Creatine amidohydrolase) is a hydrolase that catalyzes the hydrolysis of creatine into sarcosine and urea, and plays an important role in the enzymatic determination of creatinine concentration .
|
-
-
- HY-117410
-
PSMA-617
|
Drug-Linker Conjugates for ADC
|
Cancer
|
Vipivotide tetraxetan (PSMA-617) is a high potent prostate-specific membrane antigen (PSMA) inhibitor, with a Ki of 0.37 nM. Vipivotide tetraxetan (PSMA-617) is designed consisting of three components: the pharmacophore Glutamate-urea-Lysine, the chelator DOTA able to complex both 68Ga or 177Lu, and a linker connecting these two entities. Glutamate-urea-Lysine is the selective pharmacophore to bind to prostate specific membrane antigen.
|
-
-
- HY-W018004
-
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI).
|
-
-
- HY-111606
-
-
-
- HY-W017018S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Ornithine-d6 (hydrochloride) is the deuterium labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
-
- HY-W017018S3
-
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Ornithine-d2 (hydrochloride) is the deuterium labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
-
- HY-W017018S4
-
-
-
- HY-W017018S5
-
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Ornithine- 15N2 (hydrochloride) is the 15N-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
-
- HY-145613
-
|
HDAC
|
Metabolic Disease
|
5-Phenylpentan-2-one is a potent histone deacetylases (HDACs) inhibitor. 5-Phenylpentan-2-one can be used for urea cycle disorder research .
|
-
-
- HY-146756
-
|
Bacterial
|
Infection
|
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) is an antibacterial pleuromutilin derivative against Gram-positive pathogens (GPPs) and Mycoplasma pneumoniae .
|
-
-
- HY-W018004S
-
-
-
- HY-W017018S1
-
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Ornithine-1,2- 13C2 (hydrochloride) is the 13C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
-
- HY-101867
-
AU1235
2 Publications Verification
|
Bacterial
|
Infection
Cancer
|
AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane .
|
-
-
- HY-23337S
-
|
Isotope-Labeled Compounds
|
Others
|
1-Methyl-3-((tetrahydrofuran-3-yl)methyl)urea-d3 is the deuterium labeled γ-Tocotrienol. γ-Tocotrienol is an active form of vitamin E[1].
|
-
-
- HY-W017018S2
-
-
-
- HY-W010382S
-
2-Oxosuccinic acid-13C4
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Metabolic Disease
|
Oxaloacetic acid- 13C4 is the 13C-labeled Oxaloacetic acid. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis[1][2][3].
|
-
-
- HY-155642
-
|
Urea Transporter
|
Metabolic Disease
|
PU-48 is a potent urea transporters A (UT-A) inhibitor (IC50=0.32 μM). PU-48 has a good diuretic effect in mouse models, and shows little or no cytotoxicity. PU-48 has the potential to be developed as a diuretic .
|
-
- HY-151769
-
|
ADC Linker
|
Others
|
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-108717
-
Protease K
|
Ser/Thr Protease
|
Others
|
Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection .
|
-
- HY-145889
-
|
Others
|
Others
|
LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC50s of 140 and 74.1 nM for WIL-FL * and WIL-FL * T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer .
|
-
- HY-113149
-
|
Endogenous Metabolite
Reactive Oxygen Species
|
Inflammation/Immunology
|
Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid by argininosuccinic acid lyase (ASL). Argininosuccinic acid reduces reduced glutathione (GSH) level, and increases the production of reactive oxygen species in cerebral cortex and striatum. Argininosuccinic acid causes lipid peroxidation and protein oxidation, and induces oxidative stress in the developing rat brain .
|
-
- HY-P2838
-
Creatinine amidohydrolase; CAH
|
Endogenous Metabolite
|
Metabolic Disease
|
Creatininase (EC 3.5.2.10) (Creatinine amidohydrolase; CAH), namely creatinine amidohydrolase, from Pseudomonas putida, is a homohexameric enzyme commonly used in biochemical research. Creatininase acts on carbon-nitrogen bonds other than peptide bonds, and can catalyze the hydrolysis of creatinine to creatine, which can then be metabolized by creatinase to urea and sarcosine .
|
-
- HY-P2911
-
GLDH
|
Mitochondrial Metabolism
|
Others
|
Glutamate dehydrogenase NAD(P) (GLDH) can be found in hepatocytes, renal tissue, brain, muscle, and intestinal cells. Glutamate dehydrogenase NAD(P) is often used in biochemical studies. Glutamate dehydrogenase is a mitochondrial enzyme, it catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate (α-KG) as part of the urea cycle .
|
-
- HY-113149A
-
|
Endogenous Metabolite
Reactive Oxygen Species
|
Inflammation/Immunology
|
Argininosuccinic acid disodium participates in the fourth step of the urea cycle and is cleaved into arginine and fumarate by argininosuccinate lyase (ASL). Argininosuccinic acid disodium reduces reduced glutathione (GSH) concentrations and increases reactive oxygen species production in the cerebral cortex and striatum. Argininosuccinic acid disodium causes lipid peroxidation and protein oxidation and also induces oxidative stress in the developing rat brain .
|
-
- HY-113149R
-
|
Endogenous Metabolite
Reactive Oxygen Species
|
Inflammation/Immunology
|
Argininosuccinic acid (Standard) is the analytical standard of Argininosuccinic acid. This product is intended for research and analytical applications. Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid by argininosuccinic acid lyase (ASL). Argininosuccinic acid reduces reduced glutathione (GSH) level, and increases the production of reactive oxygen species in cerebral cortex and striatum. Argininosuccinic acid causes lipid peroxidation and protein oxidation, and induces oxidative stress in the developing rat brain .
|
-
- HY-N0157R
-
6-Carboxyuracil (Standard); Vitamin B13 (Standard)
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Metabolic Disease
|
Orotic acid (Standard) is the analytical standard of Orotic acid. This product is intended for research and analytical applications. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats .
|
-
- HY-Y0032
-
|
Orthopoxvirus
|
Infection
Others
Cancer
|
Thiosemicarbazide is a vitamin B6 antagonist with anti-acne activity. Thiosemicarbazide is also a well-known source in the synthesis of heterocycles, and its derivatives have potential anticancer activity. Thiosemicarbazide (TSC: HL1) reacts with metal salts, urea (U), to prepare Co(II) and Cu(I) metal complexes. Thiosemicarbazide is also used in the fields of media communications and optical storage, and in the spectrophotometric detection of metals .
|
-
- HY-N0157S1
-
6-Carboxyuracil-13C,15N2 monohydrate; Vitamin B13-13C,15N2 monohydrate
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Metabolic Disease
|
Orotic acid- 13C, 15N2 (monohydrate) is the 13C and 15N labeled Orotic acid[1]. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[2][3][4].
|
-
- HY-146122
-
-
- HY-155240
-
|
Tyrosinase
|
Cancer
|
Tyrosinase-IN-13 (compound 3c), a derivative of Flurbiprofen (HY-10582), is a potent, non-competitive tyrosinase inhibitor (IC50=68 μM; Ki=36.3 μM). Tyrosinase-IN-13 is cytotoxic against hepatocellular carcinoma (HepG2), colorectal cancer (HT-29), and melanoma (B16F10) .
|
-
- HY-145872
-
|
HBV
|
Infection
|
HBV-IN-20 is a potent and oral active HBV inhibitor with an EC50 of 0.46 µM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators) .
|
-
- HY-146124
-
-
- HY-150506
-
|
Parasite
|
Infection
|
SPR7 (compound 7) is a potent and selective rhodesain inhibitor, with a Ki of 0.51 nM. SPR7 shows antiparasitic activity against T. b. brucei, with an EC50 of 1.65 μM .
|
-
- HY-146123
-
-
- HY-144743
-
|
Phosphodiesterase (PDE)
|
Others
|
ATX inhibitor 12 (compound 20) is an orally active and potent ATX (autotaxin) inhibitor, with an IC50 of 1.72 nM. ATX inhibitor 12 effectively alleviates lung structural damage with fewer fibrotic lesions at an oral dose of 60 mg/kg in C57Bl/6J mice. ATX inhibitor 12 can be uesd for idiopathic pulmonary fibrosis (IPF) research .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-108717
-
Protease K
|
Biochemical Assay Reagents
|
Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection .
|
-
- HY-P2911
-
GLDH
|
Biochemical Assay Reagents
|
Glutamate dehydrogenase NAD(P) (GLDH) can be found in hepatocytes, renal tissue, brain, muscle, and intestinal cells. Glutamate dehydrogenase NAD(P) is often used in biochemical studies. Glutamate dehydrogenase is a mitochondrial enzyme, it catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate (α-KG) as part of the urea cycle .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-W141774
-
S-Carboxyethylcysteine
|
Peptides
|
Metabolic Disease
|
S-(2-Carboxyethyl)-L-cysteine (S-Carboxyethylcysteine) is a non-protein (modified) sulfur amino acid. S-(2-Carboxyethyl)-L-cysteine is present in Acacia seed. S-(2-Carboxyethyl)-L-cysteine can affect the seed’s protein use in rats. S-(2-Carboxyethyl)-L-cysteine suppresses the methionine-induced growth rate, and has a negative effect on the plasma amino acid levels in rats .
|
-
- HY-P5290
-
|
PSMA
|
Cancer
|
HYNIC-PSMA is a ligand for molecular imaging of tumors. Hynic-psma consists of two components: HYNIC (6-hydrazinonicotinamide) and PSMA (Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules, such as 188Re-HYNIC-PSMA. PSMA is a membrane antigen that is specifically expressed on the surface of prostate cancer cells. HYNIC-PSMA can be used in prostate cancer research .
|
-
- HY-P5292
-
|
PSMA
|
Cancer
|
HYNIC-iPSMA is a ligand for molecular imaging of tumors. Hynic-ipsma consists of two components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/HYNIC-iPSMA has excellent specificity and sensitivity .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-Y0271S1
-
|
Urea-d4 is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
-
- HY-Y0271S2
-
|
Urea- 13C, 15N2 is the 13C and 15N labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
-
- HY-Y0271S
-
|
Urea- 15N2 is the 15N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
-
- HY-118877
-
|
Urea- 13C is the 13C labelled urea. The Urea- 13C breath test ( 13C-UBT) is one of the best methods for the diagnosis of Helicobacter pylori infection[1].
|
-
-
- HY-B2020S
-
|
Fenuron-d5 is the deuterium labeled Fenuron. Fenuron is a phenyl urea-based widely used herbicide[1].
|
-
-
- HY-W017018S
-
|
L-Ornithine-d6 (hydrochloride) is the deuterium labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
-
- HY-W017018S3
-
|
L-Ornithine-d2 (hydrochloride) is the deuterium labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
-
- HY-W017018S4
-
|
L-Ornithine-d7 (hydrochloride) is the deuterium labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
-
- HY-W017018S5
-
|
L-Ornithine- 15N2 (hydrochloride) is the 15N-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
-
- HY-W018004S
-
|
L-Homocitrulline-d3 is the deuterium labeled L-Homocitrulline. L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI).
|
-
-
- HY-W017018S1
-
|
L-Ornithine-1,2- 13C2 (hydrochloride) is the 13C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
-
- HY-23337S
-
|
1-Methyl-3-((tetrahydrofuran-3-yl)methyl)urea-d3 is the deuterium labeled γ-Tocotrienol. γ-Tocotrienol is an active form of vitamin E[1].
|
-
-
- HY-W017018S2
-
|
L-Ornithine-1,2,3,4,5- 13C5 (hydrochloride) is the 13C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
-
- HY-W010382S
-
|
Oxaloacetic acid- 13C4 is the 13C-labeled Oxaloacetic acid. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis[1][2][3].
|
-
-
- HY-N0157S1
-
|
Orotic acid- 13C, 15N2 (monohydrate) is the 13C and 15N labeled Orotic acid[1]. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[2][3][4].
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-134749
-
|
|
PROTAC Synthesis
Alkynes
|
Propargyl-PEG2-urea-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-PEG2-urea-C3-triethoxysilane is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-151769
-
|
|
TCO
Labeling and Fluorescence Imaging
|
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
Your information is safe with us. * Required Fields.
Inquiry Information
- Product Name:
- Cat. No.:
- Quantity:
- MCE Japan Authorized Agent: