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  2. Bacterial
  3. AU1235

AU1235 

Cat. No.: HY-101867 Purity: 99.18%
Handling Instructions

AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane.

For research use only. We do not sell to patients.

AU1235 Chemical Structure

AU1235 Chemical Structure

CAS No. : 1338780-86-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 235 In-stock
Estimated Time of Arrival: December 31
2 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 264 In-stock
Estimated Time of Arrival: December 31
10 mg USD 420 In-stock
Estimated Time of Arrival: December 31
25 mg USD 900 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2280 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane[1][2].

In Vitro

AU1235 is similarly active against MDR isolates of M. tb displaying resistance to isoniazid, rifampicin, and pyrazinamide in addition to streptomycin, fluoroquinolones and/or ethambutol. AU1235 also inhibits Mycobacterium smegmatis and Mycobacterium fortuitum although the MICs (3.2 to 6.4 μg/ml) are significantly higher than against M. tb and M. bovis BCG[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

324.34

Formula

C₁₇H₁₉F₃N₂O

CAS No.

1338780-86-1

SMILES

O=C(NC(C=CC(F)=C1F)=C1F)NC2(C[[email protected]](C3)C4)C[[email protected]]4C[[email protected]]3C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (77.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0832 mL 15.4159 mL 30.8318 mL
5 mM 0.6166 mL 3.0832 mL 6.1664 mL
10 mM 0.3083 mL 1.5416 mL 3.0832 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

AU1235AU 1235AU-1235BacterialcellwallsynthesisMycobacteriumtuberculosisMmpL3transportInhibitorinhibitorinhibit

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AU1235
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HY-101867
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