1338780-86-1
1338780-86-1
Chemical Structure
AU1235
- CAS No.: 1338780-86-1
- Formula:C17H19F3N2O
- Molecular Weight:324.34
IUPAC Name: 1-((3s,5s,7s)-adamantan-1-yl)-3-(2,3,4-trifluorophenyl)urea
InChIKey: PYDHHHKUANVSJV-ICCVPIAFSA-N
SMILES: O=C(NC(C=CC(F)=C1F)=C1F)NC2(C[C@H](C3)C4)C[C@H]4C[C@H]3C2
Biological Activity: AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane[1][2].
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AU1235 | 98.23% | AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane. | ||||||||||||||||||||
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AU1235 (Standard) | ≥98% | AU1235 (Standard) is the analytical standard of AU1235 (HY-101867). This product is intended for research and analytical applications. AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane. | ||||||||||||||||||||
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References
- [1]. McNeil MB, et al. Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors. mSphere. 2020;5(5):e00985-20. Published 2020 Oct 14. [Content Brief]
- [2]. Grzegorzewicz AE, et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012;8(4):334-341. Published 2012 Feb 19. [Content Brief]
Keywords
