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Results for "

urease

" in MedChemExpress (MCE) Product Catalog:

52

Inhibitors & Agonists

3

Biochemical Assay Reagents

3

Peptides

7

Natural
Products

3

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1235
    Acetohydroxamic acid
    1 Publications Verification

    N-Hydroxyacetamide

    		 Bacterial HIV Infection Inflammation/Immunology
    Acetohydroxamic acid is the inhibitor for bacterial and plant urease that can be used for chronic urinary tract infections. Acetohydroxamic acid selectively inhibits arachidonic acid 5-lipoxygenase that is useful in the research of asthma. Acetohydroxamic acid inhibits the formation of advanced glycation end products, and reduces oxidative stress and inflammatory responses. Acetohydroxamic acid exhibits antiviral activity against HIV .
    Acetohydroxamic acid
  • HY-P2767
    Urease, Jack bean
    1 Publications Verification

    		 Bacterial Others
    Urease, Jack bean is derived from jack bean and Catalyzes hydrolysis of urea to carbon dioxide and ammonia. Urease, Jack bean is useful in the determination of urea in body fluids.
    Urease, Jack bean
  • HY-W015551
    trans-2-Decenal

    (E)-Dec-2-enal

    		 Bacterial Reactive Oxygen Species (ROS) Infection
    trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC50 of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici .
    trans-2-Decenal
  • HY-100956
    Flurofamide

    		Bacterial Urease Infection Metabolic Disease
    Flurofamide is an effective bacterial urease inhibitor and antibacterial agent. Flurofamide inhibits urease and partially inhibits the chemotactic activity of Helicobacter pylori strain CPY3401. Flurofamide inhibits the growth of Ureaplasma urealyticum. Flurofamide reduces blood ammonia. Flurofamide can be used in the research of infectious urinary stones .
    Flurofamide
  • HY-N2224
    Guaijaverin

    		Bacterial Infection
    Guaijaverin is a urease inhibitor with an IC50 of 120 μM. Guaijaverin shows antioxidant and anti-Streptococcus mutans activities .
    Guaijaverin
  • HY-107199
    N-Butylthiophosphoric triamide

    NBPT

    		 Environmental Pollutants Urease Others
    N-Butylthiophosphoric triamide (NBPT) is a potent urease inhibitor. Butylthiophosphoric triamide inhibits nitrification and reduces the conversion of urea to NH3 gas .
    N-Butylthiophosphoric triamide
  • HY-E70003
    Glutamate dehydrogenase

    		Biochemical Assay Reagents Endocrinology
    Glutamate dehydrogenase is an enzyme in both prokaryotes and eukaryotic mitochondria. Glutamate dehydrogenase can be used for the enzymatic determination of ammonia, alpha-ketoglutaric acid, L-glutamate and urease .
    Glutamate dehydrogenase
  • HY-118877
    Urea-13C
    1 Publications Verification

    Carbonyl diamide-13C

    		 Isotope-Labeled Compounds Infection
    Urea- 13C is the 13C labelled urea. The Urea- 13C breath test ( 13C-UBT) is one of the best methods for the diagnosis of Helicobacter pylori infection .
    Urea-13C
  • HY-P5290
    HYNIC-PSMA

    		Radionuclide-Drug Conjugates (RDCs) PSMA Cancer
    HYNIC-PSMA is a ligand for molecular imaging of tumors. Hynic-psma consists of two components: HYNIC (6-hydrazinonicotinamide) and PSMA (Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules, such as 188Re-HYNIC-PSMA. PSMA is a membrane antigen that is specifically expressed on the surface of prostate cancer cells. HYNIC-PSMA can be used in prostate cancer research . HYNIC-PSMA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    HYNIC-PSMA
  • HY-W000932
    Butylboronic acid

    		Urease Phosphatase Endocrinology
    Butylboronic acid is a competitive soybean urease inhibitor with an IC50 of 2.9 mM and a Ki of 1.5 mM .
    Butylboronic acid
  • HY-P5292A
    HYNIC-iPSMA TFA

    		Radionuclide-Drug Conjugates (RDCs) PSMA Cancer
    HYNIC-iPSMA TFA is a ligand for molecular imaging of tumors. Hynic-ipsma consists of two components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/HYNIC-iPSMA TFA has excellent specificity and sensitivity . HYNIC-iPSMA TFA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    HYNIC-iPSMA TFA
  • HY-B1235R
    Acetohydroxamic acid (Standard)

    N-Hydroxyacetamide (Standard)

    		 Reference Standards Bacterial HIV Infection Inflammation/Immunology
    Acetohydroxamic acid (Standard) is the analytical standard of Acetohydroxamic acid. This product is intended for research and analytical applications. Acetohydroxamic acid is the inhibitor for bacterial and plant urease that can be used for chronic urinary tract infections. Acetohydroxamic acid selectively inhibits arachidonic acid 5-lipoxygenase that is useful in the research of asthma. Acetohydroxamic acid inhibits the formation of advanced glycation end products, and reduces oxidative stress and inflammatory responses. Acetohydroxamic acid exhibits antiviral activity against HIV .
    Acetohydroxamic acid (Standard)
  • HY-W090317
    2,5-Dimethyl-1,4-benzoquinone

    DMBQ; 2,5-Dimethyl-p-quinone; Phlorone

    		 Urease Others
    2,5-Dimethyl-1,4-benzoquinone is a jack bean urease (HY-P2767) inhibitor (IC50: 0.98 μM). 2,5-Dimethyl-1,4-benzoquinone can be used in the study of soil urease activity in agriculture .
    2,5-Dimethyl-1,4-benzoquinone
  • HY-147787
    Urease-IN-3

    		Bacterial Urease Infection
    Urease-IN-3 (Compound L12) is a potent inhibitor of Urease with an IC50 of 1.449 μM. Urease-IN-3 is a flavonoid analogue compound .
    Urease-IN-3
  • HY-161998
    Urease-IN-16

    		Bacterial Urease Others
    Urease-IN-16 (compound 4e) is a urease inhibitor, with an IC50 value of 132 μmol/L. Urease-IN-16 can coordinate with the nickel atom through the oxygen atoms of carbonyl or boronic acid groups. Urease-IN-16 shows great potential as an additive in the development of efficient fertilizers and medical applications .
    Urease-IN-16
  • HY-P5292
    HYNIC-iPSMA

    		Radionuclide-Drug Conjugates (RDCs) PSMA Cancer
    HYNIC-iPSMA is a ligand for molecular imaging of tumors. Hynic-ipsma consists of two components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/HYNIC-iPSMA has excellent specificity and sensitivity . HYNIC-iPSMA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    HYNIC-iPSMA
  • HY-107792
    Benurestat

    		Bacterial Infection
    Benurestat is an orally active urease inhibitor. Benurestat can be used for infected ureolysis research .
    Benurestat
  • HY-115939
    Urease-IN-2

    		Bacterial Urease Infection
    Urease-IN-2 (compound 8g) is a non-competitive urease inhibitor with an IC50 of 0.94 μM and a Ki of 1.6 μM. Urease-IN-2 inhibits the Jack bean urease (JBU) in a non-competitive manner .
    Urease-IN-2
  • HY-175644
    Urease-IN-22

    		Urease Others
    Urease-IN-22 (Compound 9L) is a Urease inhibitor with an IC50 of 0.15  μM. Urease-IN-22 is a piperazine-based derivative of Benzimidazole (HY-Y1825) .
    Urease-IN-22
  • HY-156369
    Urease-IN-9

    		Bacterial Infection
    Urease-IN-9 (Compound 1e) is an urease inhibitor (IC50: 19.5?μM) .
    Urease-IN-9
  • HY-W357738
    Urease-IN-14

    		Bacterial Urease Infection
    Urease-IN-14 (compound 15) is an urease inhibitor and antioxidant. Urease-IN-14 shows DPPH radical scavenging and urease inhibitory activities with IC50 values 151.7 μM and 41.6 μM, respectively .
    Urease-IN-14
  • HY-149775
    Urease-IN-10

    		Bacterial Urease Infection
    Urease-IN-10 (Conjugate 4) is a competitive Urease inhibitor, with an IC50 of 3.59±0.07 μM and a Ki of 7.45 μM. Urease-IN-10 is a conjugate consisting of Diclofenac (HY-15036) and Sulfanilamide (HY-B0242). Diclofenac-sulfanilamide inhibits the Jack bean urease(JBU) in a competitive manner .
    Urease-IN-10
  • HY-168434
    Urease-IN-19

    		Urease Metabolic Disease
    Urease-IN-19 (Compound 3c) is a potent urease inhibitor with an IC50 value of 2.7 µM. Urease-IN-19 is promising for research of kidney stones and stomach ulcers .
    Urease-IN-19
  • HY-155973
    Urease-IN-8

    		Bacterial Infection Inflammation/Immunology
    Urease-IN-8 (Compound 5e) is a competitive Urease inhibitor (IC50: 3.51 μM, Ki: 3.11 μM). Urease-IN-8 can be used for research of peptic and gastric ulcers .
    Urease-IN-8
  • HY-155970
    Urease-IN-7

    		Bacterial Infection Inflammation/Immunology
    Urease-IN-7 (Compound 5k) is a competitive Urease inhibitor (IC50: 3.33 μM, Ki: 3.62 μM). Urease-IN-7 can be used for research of peptic and gastric ulcers .
    Urease-IN-7
  • HY-W278232
    Urease-IN-6

    		Bacterial Urease Infection
    Urease-IN-6 is a potent inhibitor of Urease with an IC50 of 14.2 μM. Urease-IN-6 can be used in study peptic and gastric ulcers .
    Urease-IN-6
  • HY-175169
    Urease-IN-21

    		Bacterial Urease Infection
    Urease-IN-21 (Compound 11b) is a Urease inhibitor with an IC50 of 0.12  μM. Urease-IN-21 has potent antibacterial activity against helicobacter pylori (H. pylori) and inhibitor activity against P450 enzyme (CYP2C19, CYP2C9, and CYP3A4). Urease-IN-21 can be used for H. pylori infection research .
    Urease-IN-21
  • HY-W012824
    4-Amino-m-cresol

    		Biochemical Assay Reagents Others
    4-Amino-m-cresol inhibits soil urease activity .
    4-Amino-m-cresol
  • HY-N2224R
    Guaijaverin (Standard)

    		Reference Standards Bacterial Infection
    Guaijaverin (Standard) is the analytical standard of Guaijaverin. This product is intended for research and analytical applications. Guaijaverin is a urease inhibitor with an IC50 of 120 μM. Guaijaverin shows antioxidant and anti-Streptococcus mutans activities .
    Guaijaverin (Standard)
  • HY-162139
    Urease-IN-11

    		Bacterial Inflammation/Immunology
    Urease-IN-11 (Compound 6e) is a competitive urease inhibitor (IC50)=10.41 µM). Urease-IN-11 can be used to study diseases such as urease-related gastritis and peptic ulcer .
    Urease-IN-11
  • HY-157354
    Urease Agar Base

    		Biochemical Assay Reagents Others
    Urease Agar Base can be used for the detection of urease activity .
    Urease Agar Base
  • HY-W237498
    Urease-IN-17

    		Bacterial Infection Inflammation/Immunology
    Urease-IN-17 (9) is a urease inhibitor, with an IC50 of 84 μM .
    Urease-IN-17
  • HY-163404
    Urease-IN-13

    		Bacterial Infection Inflammation/Immunology
    Urease-IN-13 (compound d8) is an inhibitor of urease with an IC50 value of 1.21 μM. Urease-IN-13 can be used in the study of infectious gastritis and gastric ulcer .
    Urease-IN-13
  • HY-141806
    Urease-IN-1

    		Bacterial Infection
    Urease-IN-1 is an urease inhibitor with an IC50 value of 2.21 ± 0.45 µM.
    Urease-IN-1
  • HY-152669
    Urease-IN-5

    		Bacterial Infection
    Urease-IN-5 is an inhibitor of urease with an IC50 value of 1.473 µM. Urease-IN-5 has low cytotoxicity and inhibitory activity on P. vulgaris with an IC50 value of 17.78 µg/mL .
    Urease-IN-5
  • HY-170937
    Urease-IN-20

    		Bacterial Apoptosis Reactive Oxygen Species (ROS) Infection
    Urease-IN-20 (compound XBP2) is an inhibitor of Helicobacter pylori (H. pylori). Urease-IN-20 inhibits H. pylori with an IC50 of 0.14 μM. Urease-IN-20 reduces cell Apoptosis and decreases ROS and γH2AX in GES-1 cells infected with H. pylori. Urease-IN-20 exhibits significant gastric mucosal protective effects. Urease-IN-20 shows the potential for H. pylori research .
    Urease-IN-20
  • HY-152668
    Urease-IN-4

    		Bacterial Infection
    Urease-IN-4 is an effective inhibitor of urease with an IC50 value of 1.64 µM. Urease-IN-4 has low cytotoxicity and shows inhibitory activity on P. vulgaris with an IC50 value of 15.27 µg/mL .
    Urease-IN-4
  • HY-161761
    Urease-IN-15

    		Bacterial Infection
    Urease-IN-15 (compound 5g) is an uncompetitive inhibitor of urease in manner with the IC50 of 3.80 µM .
    Urease-IN-15
  • HY-162149
    Urease-IN-12

    		Bacterial Infection
    Urease-IN-12 (compound 5e) is a competitive urease inhibitor (IC50: 0.35 μM) with the potential to inhibit gastritis and peptic ulcer caused by Helicobacter pylori .
    Urease-IN-12
  • HY-N9746
    (R)-4-Methoxydalbergione

    		Parasite Infection
    (R)-4-Methoxydalbergione is a urease inhibitor with IC50s of 59.72 and 67.33 μM for Bacillus pasteurii urease and Jack bean urease. (R)-4-Methoxydalbergione also has antiplasmodial activity. (R)-4-Methoxydalbergione can be isolated from Ranunculus repens .
    (R)-4-Methoxydalbergione
  • HY-W013007
    4-Hexen-3-one

    2-Hexen-4-one

    		 Endogenous Metabolite Bacterial Infection Inflammation/Immunology
    4-Hexen-3-one inhibits the growth of H. pylori strain ATCC 43526 and TDR H. pylori strains. 4-Hexen-3-one inhibits urease activities .
    4-Hexen-3-one
  • HY-170608
    Urease-IN-18

    		Bacterial Infection
    Urease-IN-18 (compound 13a) is an uncompetitive urease inhibitor with an IC50 value of 1.6 μM. Urease helps maintain an alkaline environment favorable for the survival and proliferation of specific pathogens within the host .
    Urease-IN-18
  • HY-181149
    Urease/thymidine phosphorylase-IN-1

    		Urease Bacterial Infection Cancer
    Urease/thymidine phosphorylase-IN-1 (compound 8) is a urease and thymidine phosphorylase inhibitor with a urease IC50 of 8.20 μM, thymidine phosphorylase IC50 of 9.29 μM. Urease/thymidine phosphorylase-IN-1 can be used for the research of helicobacter pylori infection, proteus mirabilis infection, cancer .
    Urease/thymidine phosphorylase-IN-1
  • HY-N15412
    Cabreuvin

    		Bacterial Others
    Cabreuvin is an isoflavonoid compound that can be isolated and extracted from Calopogonium mucunoides. Cabreuvin has a weak inhibitory activity against urease .
    Cabreuvin
  • HY-W711323
    Flurofamide-d4

    		Isotope-Labeled Compounds Bacterial Infection
    Flurofamide-d4 is the deuterium labeled Flurofamide (HY-100956). Flurofamide is a potent bacterial urease inhibitor with potential in the treatment of infection induced urinary stones .
    Flurofamide-d4
  • HY-155521
    Enzyme-IN-2

    		Bacterial Infection
    Enzyme-IN-2 (compound 15) is a ureases inhibitor (Ki=2.36 μM) with anti-ureolytic activity (IC50=0.75 μM) .
    Enzyme-IN-2
  • HY-W015551R
    trans-2-Decenal (Standard)

    (E)-Dec-2-enal (Standard)

    		 Biochemical Assay Reagents Reference Standards Infection
    trans-2-Decenal ((E)-Dec-2-enal)) Standard is the analytical standard of trans-2-Decenal (HY-W015551). This product is intended for research and analytical applications. trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC50 of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici.
    trans-2-Decenal (Standard)
  • HY-W015551S
    trans-2-Decenal-d2

    (E)-Dec-2-enal-d2

    		 Biochemical Assay Reagents Isotope-Labeled Compounds Infection
    trans-2-Decenal-d2 ((E)-Dec-2-enal-d2) is deuterated labeled trans-2-Decenal (HY-W015551). trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC50 of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici .
    trans-2-Decenal-d2
  • HY-161860
    Antibacterial agent 233

    		Bacterial Cancer
    Antibacterial agent 233 (Compound 7c) exhibits inhibitory efficacy against Helicobacter pylori with MIC of 0.4-1.6 μg/mL. Antibacterial agent 233 inhibits jack bean urease (IC50 is 0.27 μg/mL), changes the permeability of H. pylori cell membrane, causes the leakage of cellular contents. Antibacterial agent 233 exhibits metabolic stability in whole blood and artificial gastric fluid. Antibacterial agent 233 exhibits antitumor efficacy against U2OS in mice .
    Antibacterial agent 233
  • HY-173428
    Antifungal agent 130

    		Fungal Infection
    Antifungal agent 130 (Compound A7) is an orally active antifungal agent. Antifungal agent 130 has good antifungal activity against Candida albicans (MIC = 0.12 ng/mL) and Cryptococcus neoformans (MIC = 0.12 ng/mL) and has excellent antivirulence effect. Antifungal agent 130 exerts its antifungal effect by disrupting the iron homeostasis of fungal cells and inducing oxidative stress damage. Antifungal agent 130 can inhibit the formation of fungal virulence factors (such as biofilm, capsule, urease and melanin). Antifungal agent 130 has good antifungal effect and can be used in the study of drug-resistant fungal infections .
    Antifungal agent 130

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