2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Bacterial Reactive Oxygen Species (ROS)
  4. trans-2-Decenal

trans-2-Decenal  (Synonyms: (E)-Dec-2-enal)

Cat. No.: HY-W015551 Purity: 98.33%
COA
SDS
Handling Instructions Technical Support

trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC50 of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici.

For research use only. We do not sell to patients.

trans-2-Decenal

trans-2-Decenal Chemical Structure

CAS No. : 3913-81-3

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Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

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trans-2-Decenal Related Antibodies

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Description

trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC50 of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici[1][2].

In Vitro

trans-2-Decenal (4-512 μg/mL; 3-5 d) exhibits in vitro bacteriostatic and bactericidal activities against clinically drug-resistant strains of Helicobacter pylori (C907, C101, R1, R2, R4, R10, R16, R24, R36, R40) and the standard strain ATCC43504, with MIC values ranging from 8 to 16 μg/mL and MBC values ranging from 16 to 32 μg/mL[1].
trans-2-Decenal (4-16 μg/mL; 72 h) inhibits the growth of the standard Helicobacter pylori strain ATCC43504 in a concentration-dependent manner within 72 h, with complete growth inhibition achieved at 16 μg/mL[1].
trans-2-Decenal (16-64 μg/mL; 24 h) exhibits rapid, concentration-dependent bactericidal activity against the standard Helicobacter pylori strain ATCC43504: 16 μg/mL eliminates all viable bacteria within 4 h, while complete bactericidal effect is achieved within 1 h at 32 μg/mL or 64 μg/mL[1].
trans-2-Decenal (16 μg/mL; 4 h) alters the morphology of the standard Helicobacter pylori strain ATCC43504 and causes damage to its ultrastructure after 4 h of incubation[1].
trans-2-Decenal (8-64 μg/mL; 1-3 d) inhibits biofilm formation and mature biofilm growth of the standard Helicobacter pylori strain ATCC43504 in a concentration-dependent manner, with the maximum inhibitory effect achieved at 16 μg/mL[1].
trans-2-Decenal (0-16 μg/mL; 20 min) inhibits Helicobacter pylori urease activity in a concentration-dependent manner, with an IC50 of 9.484 μg/mL[1].
trans-2-Decenal (4-32 μg/mL; 4 d) inhibits the migration ability of the standard Helicobacter pylori strain ATCC43504 in a concentration-dependent manner, and complete growth inhibition is observed at the concentration of 32 μg/mL[1].
Trans-2-decenal (16-32 μg/mL; 12-48 h) induces dose-dependent intracellular ROS accumulation and depletes glutathione levels in Phytophthora capsici strain LT263: a strong DCFH-DA fluorescence signal is detected at the concentration of 32 μg/mL after 12 h of treatment; after 48 h of treatment, the GSH content decreases to 44.39% of that in the control group at the concentration of 32 μg/mL[2].
Trans-2-decenal (16-32 μg/mL; 12 h) dose-dependently disrupts the mitochondrial membrane potential of Phytophthora capsici strain LT263[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

trans-2-Decenal Related Antibodies
Molecular Weight

154.25

Formula

C10H18O
CAS No.
Appearance

Liquid (Density: 0.841 g/cm3)

Color

Colorless to light yellow

SMILES

CCCCCCC/C=C/C=O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (1296.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4830 mL 32.4149 mL 64.8298 mL
5 mM 1.2966 mL 6.4830 mL 12.9660 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (32.41 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (32.41 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 98.33%

SDS (537 KB)

COA (240 KB) HNMR (241 KB) GC (386 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.4830 mL 32.4149 mL 64.8298 mL 162.0746 mL
5 mM 1.2966 mL 6.4830 mL 12.9660 mL 32.4149 mL
10 mM 0.6483 mL 3.2415 mL 6.4830 mL 16.2075 mL
15 mM 0.4322 mL 2.1610 mL 4.3220 mL 10.8050 mL
20 mM 0.3241 mL 1.6207 mL 3.2415 mL 8.1037 mL
25 mM 0.2593 mL 1.2966 mL 2.5932 mL 6.4830 mL
30 mM 0.2161 mL 1.0805 mL 2.1610 mL 5.4025 mL
40 mM 0.1621 mL 0.8104 mL 1.6207 mL 4.0519 mL
50 mM 0.1297 mL 0.6483 mL 1.2966 mL 3.2415 mL
60 mM 0.1080 mL 0.5402 mL 1.0805 mL 2.7012 mL
80 mM 0.0810 mL 0.4052 mL 0.8104 mL 2.0259 mL
100 mM 0.0648 mL 0.3241 mL 0.6483 mL 1.6207 mL
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trans-2-Decenal Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

trans-2-Decenal3913-81-3(E)-Dec-2-enalBacterialReactive Oxygen Species (ROS)metronidazolePhytophthora capsiciclarithromycinglutathioneHelicobacter pylori ureaseATCC43504levofloxacinmitochondrial membrane potentialHelicobacter pylorireactive oxygen speciesInhibitorinhibitorinhibit

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