Cat. No.: HY-W015551

trans-2-Decenal

(Synonyms: (E)-Dec-2-enal)

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Based on 1 Customer Validation

trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici.

For research use only. We do not sell to patients.

Purity: 98.33%
CAS No.: 3913-81-3
Formula: C₁₀H₁₈O
Molecular Weight:154.25

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

trans-2-Decenal Chemical Structure

CAS No.: 3913-81-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

trans-2-Decenal (4-512 μg/mL; 3-5 d) exhibits in vitro bacteriostatic and bactericidal activities against clinically drug-resistant strains of Helicobacter pylori (C907, C101, R1, R2, R4, R10, R16, R24, R36, R40) and the standard strain ATCC43504, with MIC values ranging from 8 to 16 μg/mL and MBC values ranging from 16 to 32 μg/mL^[1].
trans-2-Decenal (4-16 μg/mL; 72 h) inhibits the growth of the standard Helicobacter pylori strain ATCC43504 in a concentration-dependent manner within 72 h, with complete growth inhibition achieved at 16 μg/mL^[1].
trans-2-Decenal (16-64 μg/mL; 24 h) exhibits rapid, concentration-dependent bactericidal activity against the standard Helicobacter pylori strain ATCC43504: 16 μg/mL eliminates all viable bacteria within 4 h, while complete bactericidal effect is achieved within 1 h at 32 μg/mL or 64 μg/mL^[1].
trans-2-Decenal (16 μg/mL; 4 h) alters the morphology of the standard Helicobacter pylori strain ATCC43504 and causes damage to its ultrastructure after 4 h of incubation^[1].
trans-2-Decenal (8-64 μg/mL; 1-3 d) inhibits biofilm formation and mature biofilm growth of the standard Helicobacter pylori strain ATCC43504 in a concentration-dependent manner, with the maximum inhibitory effect achieved at 16 μg/mL^[1].
trans-2-Decenal (0-16 μg/mL; 20 min) inhibits Helicobacter pylori urease activity in a concentration-dependent manner, with an IC₅₀ of 9.484 μg/mL^[1].
trans-2-Decenal (4-32 μg/mL; 4 d) inhibits the migration ability of the standard Helicobacter pylori strain ATCC43504 in a concentration-dependent manner, and complete growth inhibition is observed at the concentration of 32 μg/mL^[1].
Trans-2-decenal (16-32 μg/mL; 12-48 h) induces dose-dependent intracellular ROS accumulation and depletes glutathione levels in Phytophthora capsici strain LT263: a strong DCFH-DA fluorescence signal is detected at the concentration of 32 μg/mL after 12 h of treatment; after 48 h of treatment, the GSH content decreases to 44.39% of that in the control group at the concentration of 32 μg/mL^[2].
Trans-2-decenal (16-32 μg/mL; 12 h) dose-dependently disrupts the mitochondrial membrane potential of Phytophthora capsici strain LT263^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3913-81-3
Appearance Liquid (Density: 0.841 g/cm³)
Molecular Weight 154.25
Formula C₁₀H₁₈O
Color Colorless to light yellow
SMILES

CCCCCCC/C=C/C=O
Synonyms

(E)-Dec-2-enal
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (1296.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.4830 mL

32.4149 mL

64.8298 mL

5 mM

1.2966 mL

6.4830 mL

12.9660 mL

10 mM

0.6483 mL

3.2415 mL

6.4830 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (32.41 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (32.41 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Korean - KR (537 KB)
- Portuguese - PT (537 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lei H E, et al. Study on the Inhibitory Effect and Mechanism of Trans-2-Decenal on Helicobacter pylori in vitro. Journal of Sichuan University (Medical Sciences), 2026, 57(1): 124.

[2]. Xie S, et al. Trans-2-decenal inhibits Phytophthora capsici by inducing ROS accumulation and mitochondrial dysfunction. Pestic Biochem Physiol. 2025;215:106673. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.4830 mL	32.4149 mL	64.8298 mL	162.0746 mL
	5 mM	1.2966 mL	6.4830 mL	12.9660 mL	32.4149 mL
	10 mM	0.6483 mL	3.2415 mL	6.4830 mL	16.2075 mL
	15 mM	0.4322 mL	2.1610 mL	4.3220 mL	10.8050 mL
	20 mM	0.3241 mL	1.6207 mL	3.2415 mL	8.1037 mL
	25 mM	0.2593 mL	1.2966 mL	2.5932 mL	6.4830 mL
	30 mM	0.2161 mL	1.0805 mL	2.1610 mL	5.4025 mL
	40 mM	0.1621 mL	0.8104 mL	1.6207 mL	4.0519 mL
	50 mM	0.1297 mL	0.6483 mL	1.2966 mL	3.2415 mL
	60 mM	0.1080 mL	0.5402 mL	1.0805 mL	2.7012 mL
	80 mM	0.0810 mL	0.4052 mL	0.8104 mL	2.0259 mL
	100 mM	0.0648 mL	0.3241 mL	0.6483 mL	1.6207 mL

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trans-2-Decenal

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Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

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HY-W015551 Related Classifications