70788-28-2
Chemical Structure
Flurofamide
- CAS No.: 70788-28-2
- Formula:C7H9FN3O2P
- Molecular Weight:217.14
IUPAC Name: N-(diaminophosphoryl)-4-fluorobenzamide
InChIKey: QWZFVMCWPLMLTL-UHFFFAOYSA-N
SMILES: O=C(NP(N)(N)=O)C1=CC=C(F)C=C1
Biological Activity: Flurofamide is an effective bacterial urease inhibitor and antibacterial agent. Flurofamide inhibits urease and partially inhibits the chemotactic activity of Helicobacter pylori strain CPY3401. Flurofamide inhibits the growth of Ureaplasma urealyticum. Flurofamide reduces blood ammonia. Flurofamide can be used in the research of infectious urinary stones[1][2][3][4].
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Flurofamide | 92.6% | Flurofamide is an effective bacterial urease inhibitor and antibacterial agent. Flurofamide inhibits urease and partially inhibits the chemotactic activity of Helicobacter pylori strain CPY3401. Flurofamide inhibits the growth of Ureaplasma urealyticum. Flurofamide reduces blood ammonia. Flurofamide can be used in the research of infectious urinary stones. | ||||||||||||||||||||
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Flurofamide-d4 | Flurofamide-d4 is the deuterium labeled Flurofamide (HY-100956). Flurofamide is a potent bacterial urease inhibitor with potential in the treatment of infection induced urinary stones. | |||||||||||||||||||||
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- [1]. Millner OE Jr, et al. Flurofamide: a potent inhibitor of bacterial urease with potential clinical utility in the treatment of infection induced urinary stones. J Urol. 1982 Feb;127(2):346-50. [Content Brief]
- [2]. Fleming D, et al. Flurofamide Prevention and Treatment of Ureaplasma-Induced Hyperammonemia. Microbiol Spectr. 2022 Oct 26;10(5):e0192722. [Content Brief]
- [3]. Nakamura H, et al. Urease plays an important role in the chemotactic motility of Helicobacter pylori in a viscous environment. Infect Immun. 1998 Oct;66(10):4832-7. [Content Brief]
- [4]. Kenny GE. Inhibition of the growth of Ureaplasma urealyticum by a new urease inhibitor, flurofamide. Yale J Biol Med. 1983 Sep-Dec;56(5-6):717-22. [Content Brief]
Keywords
