2-Bromo-4'-fluoroacetophenone
Based on 1 Customer Validation
2-Bromo-4'-fluoroacetophenone (p-Fluorophenacyl bromide) is a photoinducible DNA cleavage inducer.2-Bromo-4'-fluoroacetophenone generates fluorine-substituted phenyl radicals upon excitation and irradiation to cleave DNA, converting circular supercoiled DNA to circular relaxed and linear DNA forms.2-Bromo-4'-fluoroacetophenone exhibits concentration-dependent DNA cleaving activity.2-Bromo-4'-fluoroacetophenone can be used for the research of cancer.
For research use only. We do not sell to patients.
- Purity: 99.15%
- CAS No.: 403-29-2
- Formula: C8H6BrFO
- Molecular Weight:217.04
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
2-Bromo-4'-fluoroacetophenone generates a reactive aryl radical after 15 min of anaerobic irradiation. This radical abstracts a deuterium atom from THF-d8 to form monodeuterated 4'-Fluoroacetophenone (HY-Y0779) with a yield of 32%[1].
2-Bromo-4'-fluoroacetophenone (0.1-100 mM; 30 min) cleaves ΦX174 RFI supercoiled DNA into nicked and linear forms in a concentration-dependent manner within 30 minutes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 403-29-2
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Appearance Solid
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Molecular Weight 217.04
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Formula C8H6BrFO
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Color Off-white to light yellow
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SMILES
BrCC(C1=CC=C(F)C=C1)=O
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Synonyms
p-Fluorophenacyl bromide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 66.67 mg/mL (307.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6074 mL | 23.0372 mL | 46.0745 mL | 115.1861 mL |
| 5 mM | 0.9215 mL | 4.6074 mL | 9.2149 mL | 23.0372 mL | |
| 10 mM | 0.4607 mL | 2.3037 mL | 4.6074 mL | 11.5186 mL | |
| 15 mM | 0.3072 mL | 1.5358 mL | 3.0716 mL | 7.6791 mL | |
| 20 mM | 0.2304 mL | 1.1519 mL | 2.3037 mL | 5.7593 mL | |
| 25 mM | 0.1843 mL | 0.9215 mL | 1.8430 mL | 4.6074 mL | |
| 30 mM | 0.1536 mL | 0.7679 mL | 1.5358 mL | 3.8395 mL | |
| 40 mM | 0.1152 mL | 0.5759 mL | 1.1519 mL | 2.8797 mL | |
| 50 mM | 0.0921 mL | 0.4607 mL | 0.9215 mL | 2.3037 mL | |
| 60 mM | 0.0768 mL | 0.3840 mL | 0.7679 mL | 1.9198 mL | |
| 80 mM | 0.0576 mL | 0.2880 mL | 0.5759 mL | 1.4398 mL | |
| 100 mM | 0.0461 mL | 0.2304 mL | 0.4607 mL | 1.1519 mL |
2-Bromo-4'-fluoroacetophenone Related Classifications
HY-W008598 Related Classifications
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